ARF6 and ASAP1

Number of citations of the paper that reports this interaction (PubMedID 18094045)
51

Data Source:
BioGRID (pull down, affinity chromatography technology)

		ARF6	ASAP1
Description		ARF GTPase 6	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Membrane Endocytic Vesicle Midbody Filopodium Membrane Early Endosome Membrane Cleavage Furrow Cell Projection Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Flemming Body Presynapse Postsynapse Glutamatergic Synapse	Golgi Membrane Podosome Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Trans-Golgi Network Membrane Centriolar Satellite
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Thioesterase Binding Signaling Adaptor Activity	GTPase Activator Activity Protein Binding Zinc Ion Binding Cadherin Binding Metal Ion Binding
	Biological Process	Mitotic Cytokinesis Liver Development Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Cell Adhesion Nervous System Development Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Protein Transport Vesicle-mediated Transport Cell Differentiation Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Endocytic Recycling Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Protein Localization To Endosome Negative Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Protein Secretion Cell Division Regulation Of Filopodium Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Dendritic Spine Development Cellular Response To Diacyl Bacterial Lipopeptide Protein Localization To Plasma Membrane Establishment Of Epithelial Cell Polarity Ruffle Assembly Hepatocyte Apoptotic Process Maintenance Of Postsynaptic Density Structure Positive Regulation Of Focal Adhesion Disassembly Erythrocyte Apoptotic Process Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Mitotic Cytokinetic Process Protein Localization To Cleavage Furrow Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Dendrite Development	Cell Projection Organization Cilium Assembly Protein Localization To Cilium Positive Regulation Of Membrane Tubulation
Pathways		TBC/RABGAPs Clathrin-mediated endocytosis MET receptor recycling	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs		5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate Myristic acid
Diseases
GWAS		Erythema nodosum in inflammatory bowel disease ( 24487271) Ferritin levels ( 33491795)	Appendicular lean mass ( 33097823) Diisocyanate-induced asthma ( 25918132) HDL cholesterol levels in HIV infection ( 33109212) Mean corpuscular volume ( 32888494) Mean platelet volume ( 27863252 32888494) Multiple sclerosis ( 19525955) Nevus count or cutaneous melanoma ( 32341527) Platelet count ( 27863252) Platelet distribution width ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Progressive supranuclear palsy ( 30089514) Refractive error ( 32231278) Sleep duration (> 10 hours) ( 33075057) Tuberculosis ( 25774636) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		40 interacting genes: AGAP1 AP1B1 AP2B1 AP3B1 AP3D1 AP3S2 APP ARFIP2 ARHGAP10 ARRB1 ARRB2 ASAP1 ASAP2 ASAP3 ATP6V0C CAPN1 CHRM3 CLTC CYTH1 CYTH2 EXOC5 EZR FILNC1 HTR2A IKBKG ITSN1 MEOX2 MT2A PALS1 PIP5K1A PIP5K1C PLD1 RAB11A RAB11FIP3 RAB11FIP4 RAB11FIP5 SMAP1 SNCA SPAG9 ZNF709	15 interacting genes: ARF1 ARF6 CBL CRK DNAJB6 GRB2 HCK PACSIN3 PTK2 PTK2B PXN RAB11FIP3 REPS2 SH3KBP1 SRC
Entrez ID		382	50807
HPRD ID		02714	05809
Ensembl ID		ENSG00000165527	ENSG00000153317
Uniprot IDs		P62330	A0A0A0MRE5 Q9ULH1
PDB IDs		1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX 6BBP 6BBQ 6PAU 7RK3 7XRD	2D1X 2DA0 2ED1 2RQT 2RQU
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Cytoplasmic Vesicle Intracellular Protein Localization Membrane Coat Establishment Of Localization In Cell Trans-Golgi Network Membrane Receptor-mediated Endocytosis Endocytosis Receptor Internalization Clathrin-coated Pit Protein Transport Melanosome Assembly Vesicle-mediated Transport In Synapse Regulation Of Vesicle-mediated Transport Cellular Localization Cytoplasmic Vesicle Membrane Organelle Localization Establishment Of Vesicle Localization Platelet Dense Granule Organization Import Into Cell Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Golgi Membrane Establishment Of Protein Localization Vesicle Localization Clathrin-dependent Endocytosis Cellular Component Assembly Endocytic Vesicle Membrane Synaptic Vesicle Transport Melanosome Organization AP-3 Adaptor Complex Pigment Granule Organization Synaptic Vesicle Endocytosis Clathrin Adaptor Complex Positive Regulation Of Endocytosis GTPase Activator Activity Presynaptic Endocytosis Plasma Membrane Lysosomal Membrane Angiotensin Receptor Binding Golgi Apparatus Establishment Of Organelle Localization Secretion Post-Golgi Vesicle-mediated Transport Secretion By Cell Localization Within Membrane Intracellular Transport Regulation Of Cellular Component Organization Protein Localization To Plasma Membrane Anterograde Synaptic Vesicle Transport Focal Adhesion	Focal Adhesion Signal Complex Assembly Regulation Of Cellular Component Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization ERBB Signaling Pathway Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Binding Regulation Of Actin Filament-based Process Enzyme-linked Receptor Protein Signaling Pathway Cytosol Regulation Of Cell Morphogenesis Endocytosis Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Actin Filament Organization Phosphotyrosine Residue Binding Positive Regulation Of Actin Filament Polymerization Vesicle-mediated Transport Plasma Membrane Positive Regulation Of Organelle Organization Regulation Of Cell Shape Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cellular Component Biogenesis Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport Positive Regulation Of Supramolecular Fiber Organization Cell Cortex Import Into Cell Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Immune Effector Process Anchoring Junction Positive Regulation Of Protein Polymerization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Cytoplasm Positive Regulation Of Cellular Component Organization Integrin-mediated Signaling Pathway Protein Localization To Cleavage Furrow SH3 Domain Binding Cellular Response To Fluid Shear Stress Protein Autophosphorylation Fc-gamma Receptor Signaling Pathway Regulation Of Actin Filament Polymerization Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activity
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