ARF6 and CHRM3

Number of citations of the paper that reports this interaction (PubMedID 12799371)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		ARF6	CHRM3
Description		ARF GTPase 6	cholinergic receptor muscarinic 3
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Membrane Endocytic Vesicle Midbody Filopodium Membrane Early Endosome Membrane Cleavage Furrow Cell Projection Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Flemming Body Presynapse Postsynapse Glutamatergic Synapse	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Dendrite Synapse Postsynaptic Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Thioesterase Binding Signaling Adaptor Activity	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity Signaling Receptor Activity Acetylcholine Binding
	Biological Process	Mitotic Cytokinesis Liver Development Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Cell Adhesion Nervous System Development Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Protein Transport Vesicle-mediated Transport Cell Differentiation Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Endocytic Recycling Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Protein Localization To Endosome Negative Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Protein Secretion Cell Division Regulation Of Filopodium Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Dendritic Spine Development Cellular Response To Diacyl Bacterial Lipopeptide Protein Localization To Plasma Membrane Establishment Of Epithelial Cell Polarity Ruffle Assembly Hepatocyte Apoptotic Process Maintenance Of Postsynaptic Density Structure Positive Regulation Of Focal Adhesion Disassembly Erythrocyte Apoptotic Process Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Mitotic Cytokinetic Process Protein Localization To Cleavage Furrow Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Dendrite Development	Smooth Muscle Contraction Regulation Of Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Nervous System Development Calcium-mediated Signaling Positive Regulation Of Insulin Secretion Protein Modification Process Positive Regulation Of Smooth Muscle Contraction Saliva Secretion Acetylcholine Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway
Pathways		TBC/RABGAPs Clathrin-mediated endocytosis MET receptor recycling	Muscarinic acetylcholine receptors Acetylcholine regulates insulin secretion G alpha (q) signalling events
Drugs		5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate Myristic acid	Cevimeline Tramadol Succinylcholine Trospium Ziprasidone Disopyramide Amitriptyline Ipratropium Olanzapine Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Oxyphencyclimine Procyclidine Loxapine Carbamoylcholine Hyoscyamine Cyproheptadine Meperidine Imipramine Methscopolamine bromide Chlorpromazine Darifenacin Haloperidol Tridihexethyl Anisotropine methylbromide Nortriptyline Amoxapine Cinnarizine Atropine Thiopental Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Dicyclomine Tropicamide Brompheniramine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Oxybutynin Promethazine Pilocarpine Doxepin Desipramine Ketamine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Isopropamide Acetylcholine Arecoline Mepenzolate ALKS 27 Pizotifen Fesoterodine Methacholine Hexocyclium Aclidinium Umeclidinium Trimebutine Dosulepin Viloxazine Etoperidone Imidafenacin Butylscopolamine Homatropine Thonzylamine Revefenacin Propiverine Rociverine Diphemanil Aripiprazole lauroxil
Diseases
GWAS		Erythema nodosum in inflammatory bowel disease ( 24487271) Ferritin levels ( 33491795)	Acute respiratory distress syndrome ( 34032881) Chronic obstructive pulmonary disease ( 30804561) Colorectal cancer ( 29228715) Depression in smokers ( 30219690) Electroencephalogram traits ( 25387704) Feeling worry ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) FEV1 ( 30804560) Generalized epilepsy ( 22949513) Gut microbiota beta diversity (weighted UniFrac distance) ( 33208821) Hallucinations in long-term cannabis use ( 31740666) Hypertension ( 17554300) Interleukin-6 (red blood cell fatty acid level interaction) ( 28820441) Lung function (FEV1/FVC) ( 28166213 30804560) Peak expiratory flow ( 30804560) Platelet count ( 21507922) Post bronchodilator FEV1 ( 26634245) Reflection (response to stress) ( 30886212) Sulfasalazine-induced agranulocytosis ( 28762467) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		40 interacting genes: AGAP1 AP1B1 AP2B1 AP3B1 AP3D1 AP3S2 APP ARFIP2 ARHGAP10 ARRB1 ARRB2 ASAP1 ASAP2 ASAP3 ATP6V0C CAPN1 CHRM3 CLTC CYTH1 CYTH2 EXOC5 EZR FILNC1 HTR2A IKBKG ITSN1 MEOX2 MT2A PALS1 PIP5K1A PIP5K1C PLD1 RAB11A RAB11FIP3 RAB11FIP4 RAB11FIP5 SMAP1 SNCA SPAG9 ZNF709	26 interacting genes: ARF1 ARF6 BSG CALM3 CCDC184 CD2BP2 COMMD7 CSNK1A1 GNAQ GNAS GPRASP1 GRK6 GZMB JAKMIP1 MAGED2 POM121C PPP1R9B RAB5IF RGS7 SEPTIN3 SET SGSM3 SNCA TAP1 TPM3 YIPF3
Entrez ID		382	1131
HPRD ID		02714	00329
Ensembl ID		ENSG00000165527	ENSG00000133019
Uniprot IDs		P62330	P20309
PDB IDs		1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX 6BBP 6BBQ 6PAU 7RK3 7XRD	2CSA 8E9W 8E9Y 8E9Z 8EA0
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Cytoplasmic Vesicle Intracellular Protein Localization Membrane Coat Establishment Of Localization In Cell Trans-Golgi Network Membrane Receptor-mediated Endocytosis Endocytosis Receptor Internalization Clathrin-coated Pit Protein Transport Melanosome Assembly Vesicle-mediated Transport In Synapse Regulation Of Vesicle-mediated Transport Cellular Localization Cytoplasmic Vesicle Membrane Organelle Localization Establishment Of Vesicle Localization Platelet Dense Granule Organization Import Into Cell Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Golgi Membrane Establishment Of Protein Localization Vesicle Localization Clathrin-dependent Endocytosis Cellular Component Assembly Endocytic Vesicle Membrane Synaptic Vesicle Transport Melanosome Organization AP-3 Adaptor Complex Pigment Granule Organization Synaptic Vesicle Endocytosis Clathrin Adaptor Complex Positive Regulation Of Endocytosis GTPase Activator Activity Presynaptic Endocytosis Plasma Membrane Lysosomal Membrane Angiotensin Receptor Binding Golgi Apparatus Establishment Of Organelle Localization Secretion Post-Golgi Vesicle-mediated Transport Secretion By Cell Localization Within Membrane Intracellular Transport Regulation Of Cellular Component Organization Protein Localization To Plasma Membrane Anterograde Synaptic Vesicle Transport Focal Adhesion	GTPase Activity Regulation Of Endocytosis Response To Prostaglandin E Regulation Of G Protein-coupled Receptor Signaling Pathway Cytoplasm Adenylate Cyclase Activator Activity Presynaptic Endocytosis Cellular Localization Establishment Of Protein Localization Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport G Protein Activity Intracellular Protein Localization GTP Binding Positive Regulation Of Protein Localization To Cell Periphery Guanyl Nucleotide Binding Establishment Of Localization In Cell Vesicle-mediated Transport In Synapse Response To Ketone Cellular Response To Acidic PH Presynapse G-protein Beta/gamma-subunit Complex Binding GTPase Activator Activity Response To Alcohol Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Response To Acidic PH Nucleotide Binding Regulation Of Cell Communication Protein Transport Regulation Of Signaling Mitotic Cleavage Furrow Ingression Membrane Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Response To Growth Factor Erythrocyte Apoptotic Process Growth Cone G Protein-coupled Receptor Signaling Pathway Response To Amphetamine Postsynaptic Cytosol Regulation Of Synaptic Vesicle Recycling Cellular Response To PH Heterotrimeric G-protein Complex Positive Regulation Of Catalytic Activity Cell Migration Involved In Coronary Angiogenesis Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity
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