ARF6 and PIP5K1C

Number of citations of the paper that reports this interaction (PMID 12847086)
64

Data Source:
HPRD (in vitro)

		ARF6	PIP5K1C
Gene Name		ADP-ribosylation factor 6	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
Image
Gene Ontology Annotations	Cellular Component	Ruffle Endosome Early Endosome Golgi Apparatus Plasma Membrane Focal Adhesion Cell Cortex Membrane Endocytic Vesicle Midbody Filopodium Membrane Cleavage Furrow Recycling Endosome Membrane Extracellular Vesicular Exosome	Phagocytic Cup Uropod Nucleus Cytosol Focal Adhesion Endomembrane System Ruffle Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Thioesterase Binding	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity Talin Binding
	Biological Process	Liver Development Movement Of Cell Or Subcellular Component Cell Cycle Cell Adhesion Small GTPase Mediated Signal Transduction Metabolic Process Protein Transport Vesicle-mediated Transport Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Ruffle Organization Myeloid Cell Apoptotic Process Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Protein Localization To Endosome Negative Regulation Of Receptor-mediated Endocytosis Cell Division Regulation Of Filopodium Assembly Regulation Of Dendritic Spine Development Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Establishment Of Epithelial Cell Polarity Hepatocyte Apoptotic Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phagocytosis Cytoskeletal Anchoring At Plasma Membrane Axon Guidance Synaptic Vesicle Exocytosis Single Organismal Cell-cell Adhesion Actin Cytoskeleton Organization Neutrophil Chemotaxis Adherens Junction Assembly Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation Synaptic Vesicle Endocytosis Platelet Aggregation Clathrin-mediated Endocytosis
Pathways			Synthesis of PIPs at the plasma membrane Axon guidance Metabolism of lipids and lipoproteins Semaphorin interactions SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Phospholipid metabolism PI Metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		28 interactors: AP1B1 AP3B1 AP3D1 AP3S2 APP ARFIP2 ARRB1 ARRB2 ASAP2 ASAP3 ATP6V0C CAPN1 CHRM3 CYTH1 CYTH2 EXOC5 EZR GGA1 IKBKG ITSN1 MPP5 PIP5K1A PIP5K1C PLD1 RAB11FIP3 RAB11FIP4 RAB11FIP5 ZNF709	9 interactors: AP1B1 AP2B1 ARF6 BTK CDH1 CDK5 HDHD2 LRP2 TLN2
Entrez ID		382	23396
HPRD ID		02714	05834
Ensembl ID			ENSG00000186111
Uniprot IDs		P62330	O60331
PDB IDs		1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX	3H1Z 3H85
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Cellular Localization Protein Localization Establishment Of Localization In Cell Establishment Of Protein Localization Transport Establishment Of Vesicle Localization Vesicle Localization Synaptic Vesicle Transport Protein Transport Movement Of Cell Or Subcellular Component Axon Cargo Transport Endocytosis Establishment Of Organelle Localization Receptor Metabolic Process Regulation Of GTPase Activity Anterograde Synaptic Vesicle Transport Regulation Of ARF Protein Signal Transduction Intracellular Transport Chemotaxis Anterograde Axon Cargo Transport Regulation Of Ras Protein Signal Transduction Organelle Localization Cellular Protein Localization Positive Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Regulation Of Small GTPase Mediated Signal Transduction Microtubule-based Transport Receptor Internalization Cytoskeleton-dependent Intracellular Transport Response To External Stimulus Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Positive Regulation Of NK T Cell Differentiation Positive Regulation Of Catalytic Activity Regulation Of Body Fluid Levels Synaptic Transmission Actin Cytoskeleton Organization Locomotion Cell-cell Signaling Platelet Activation Cytoskeletal Anchoring At Plasma Membrane Regulation Of Signaling Actin Filament-based Process Regulation Of Intracellular Signal Transduction G-protein Coupled Receptor Internalization Blood Coagulation Hemostasis Regulation Of Signal Transduction Post-Golgi Vesicle-mediated Transport Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway	Cellular Protein Localization Cellular Localization Vesicle-mediated Transport Protein Localization Regulation Of Defense Response To Virus By Virus Cortical Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Establishment Of Protein Localization Regulation Of Dendritic Spine Development Regulated Secretory Pathway Apoptotic Process Programmed Cell Death Regulation Of B Cell Cytokine Production Synapse Assembly Cell Death Death Regulation Of Defense Response To Virus Cell Division Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Forebrain Development Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Cell Projection Organization Cell Adhesion Negative Regulation Of Protein Ubiquitination Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Regulation Of Dendrite Development Nervous System Development Cellular Response To Molecule Of Fungal Origin Cell-cell Junction Assembly Regulation Of Immune System Process Negative Regulation Of Synaptic Plasticity Protein Transport Response To Molecule Of Fungal Origin Endocytosis Intracellular Transport Positive Regulation Of Intracellular Protein Transport Regulation Of Establishment Of Protein Localization Generation Of Neurons Serine Phosphorylation Of STAT3 Protein Cellular Response To Indole-3-methanol Regulation Of Cell Differentiation Synapse Organization Regulation Of Neurogenesis Cell Morphogenesis Involved In Differentiation Serine Phosphorylation Of STAT Protein Neurogenesis Brain Development Cell Junction Assembly Activation Of Anaphase-promoting Complex Activity Negative Regulation Of Protein Export From Nucleus
Tagcloud ?		accessible cellubrevin cho colocalized compartment cryoimmunogold endocytic endosomal gdp gtpase horseradish hrp invaginations localize localizes morphologically pericentriolar perinuclear perturbs q67l recycling resembled ribosylation shortly t27n tracer uniquely vesicles	ca chelator contents differentiate differentiation disrupted evoke ezh2 hmscs homolog intracellular knockdown knocking lineages mesenchymal modulates neurological neuron neuronal plc proliferating renewal repressing silenced suppress turn zeste
Tagcloud (Difference) ?		accessible cellubrevin cho colocalized compartment cryoimmunogold endocytic endosomal gdp gtpase horseradish hrp invaginations localize localizes morphologically pericentriolar perinuclear perturbs q67l recycling resembled ribosylation shortly t27n tracer uniquely vesicles	ca chelator contents differentiate differentiation disrupted evoke ezh2 hmscs homolog intracellular knockdown knocking lineages mesenchymal modulates neurological neuron neuronal plc proliferating renewal repressing silenced suppress turn zeste
Tagcloud (Intersection) ?