ARF6 and ARHGAP10

Number of citations of the paper that reports this interaction (PubMedID 16527809)
0

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		ARF6	ARHGAP10
Description		ARF GTPase 6	Rho GTPase activating protein 10
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Membrane Endocytic Vesicle Midbody Filopodium Membrane Early Endosome Membrane Cleavage Furrow Cell Projection Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Flemming Body Presynapse Postsynapse Glutamatergic Synapse	Cytoplasm Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Thioesterase Binding Signaling Adaptor Activity	GTPase Activator Activity Protein Binding
	Biological Process	Mitotic Cytokinesis Liver Development Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Cell Adhesion Nervous System Development Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Protein Transport Vesicle-mediated Transport Cell Differentiation Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Endocytic Recycling Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Protein Localization To Endosome Negative Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Protein Secretion Cell Division Regulation Of Filopodium Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Dendritic Spine Development Cellular Response To Diacyl Bacterial Lipopeptide Protein Localization To Plasma Membrane Establishment Of Epithelial Cell Polarity Ruffle Assembly Hepatocyte Apoptotic Process Maintenance Of Postsynaptic Density Structure Positive Regulation Of Focal Adhesion Disassembly Erythrocyte Apoptotic Process Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Mitotic Cytokinetic Process Protein Localization To Cleavage Furrow Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Dendrite Development	Cytoskeleton Organization Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction
Pathways		TBC/RABGAPs Clathrin-mediated endocytosis MET receptor recycling	Regulation of PAK-2p34 activity by PS-GAP/RHG10 RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs		5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate Myristic acid
Diseases
GWAS		Erythema nodosum in inflammatory bowel disease ( 24487271) Ferritin levels ( 33491795)	Atrial fibrillation ( 29892015 30061737) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Liver enzyme levels (alkaline phosphatase) ( 33972514) QT interval ( 20031603) Resting heart rate ( 27798624) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		40 interacting genes: AGAP1 AP1B1 AP2B1 AP3B1 AP3D1 AP3S2 APP ARFIP2 ARHGAP10 ARRB1 ARRB2 ASAP1 ASAP2 ASAP3 ATP6V0C CAPN1 CHRM3 CLTC CYTH1 CYTH2 EXOC5 EZR FILNC1 HTR2A IKBKG ITSN1 MEOX2 MT2A PALS1 PIP5K1A PIP5K1C PLD1 RAB11A RAB11FIP3 RAB11FIP4 RAB11FIP5 SMAP1 SNCA SPAG9 ZNF709	11 interacting genes: ANKS1A ARF6 CDC42 HRAS KLHL20 PAK2 PKN1 PKN3 RHOA SH3BP2 YWHAQ
Entrez ID		382	79658
HPRD ID		02714	07949
Ensembl ID		ENSG00000165527	ENSG00000071205
Uniprot IDs		P62330	A0A2X0SFB3 A1A4S6
PDB IDs		1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX 6BBP 6BBQ 6PAU 7RK3 7XRD	2MIO
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Cytoplasmic Vesicle Intracellular Protein Localization Membrane Coat Establishment Of Localization In Cell Trans-Golgi Network Membrane Receptor-mediated Endocytosis Endocytosis Receptor Internalization Clathrin-coated Pit Protein Transport Melanosome Assembly Vesicle-mediated Transport In Synapse Regulation Of Vesicle-mediated Transport Cellular Localization Cytoplasmic Vesicle Membrane Organelle Localization Establishment Of Vesicle Localization Platelet Dense Granule Organization Import Into Cell Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Golgi Membrane Establishment Of Protein Localization Vesicle Localization Clathrin-dependent Endocytosis Cellular Component Assembly Endocytic Vesicle Membrane Synaptic Vesicle Transport Melanosome Organization AP-3 Adaptor Complex Pigment Granule Organization Synaptic Vesicle Endocytosis Clathrin Adaptor Complex Positive Regulation Of Endocytosis GTPase Activator Activity Presynaptic Endocytosis Plasma Membrane Lysosomal Membrane Angiotensin Receptor Binding Golgi Apparatus Establishment Of Organelle Localization Secretion Post-Golgi Vesicle-mediated Transport Secretion By Cell Localization Within Membrane Intracellular Transport Regulation Of Cellular Component Organization Protein Localization To Plasma Membrane Anterograde Synaptic Vesicle Transport Focal Adhesion	G Protein Activity Establishment Of Epithelial Cell Polarity Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Positive Regulation Of Cytokinesis Substantia Nigra Development Midbody Focal Adhesion Cleavage Furrow Neural Nucleus Development Cell Migration Regulation Of Cytoskeleton Organization Thioesterase Binding Regulation Of Actin Filament Organization Glutamatergic Synapse Small GTPase-mediated Signal Transduction Cell Motility Regulation Of Cytokinesis Nucleotide Binding Positive Regulation Of Cell Division Establishment Of Cell Polarity Regulation Of Stress Fiber Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Intracellular Signal Transduction GTPase Activity Regulation Of Cell Projection Organization Establishment Of Epithelial Cell Apical/basal Polarity Diacylglycerol-dependent Serine/threonine Kinase Activity GTP Binding Regulation Of Supramolecular Fiber Organization Cytosol Ameboidal-type Cell Migration Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Signal Transduction Establishment Or Maintenance Of Cell Polarity Apoptotic Process Cell Junction Organization Positive Regulation Of Supramolecular Fiber Organization Cell Death Regulation Of Cell Division Programmed Cell Death Cell-cell Junction Organization Positive Regulation Of Cytoskeleton Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Epithelial Cell Migration Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Motility
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