ARF6 and TOGARAM1

Data Source: HiPPIP (Novel)

		ARF6	TOGARAM1
Name		ARF GTPase 6	TOG array regulator of axonemal microtubules 1
Structure			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Membrane Endocytic Vesicle Midbody Filopodium Membrane Early Endosome Membrane Cleavage Furrow Cell Projection Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Flemming Body Presynapse Postsynapse Glutamatergic Synapse	Cytoplasm Cytoskeleton Microtubule Cytoplasmic Microtubule Cilium Axoneme Ciliary Basal Body Cell Projection
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Thioesterase Binding Signaling Adaptor Activity	Protein Binding Microtubule Binding
	Biological Process	Mitotic Cytokinesis Liver Development Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Cell Adhesion Nervous System Development Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Protein Transport Vesicle-mediated Transport Cell Differentiation Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Endocytic Recycling Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Protein Localization To Endosome Negative Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Protein Secretion Cell Division Regulation Of Filopodium Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Dendritic Spine Development Cellular Response To Diacyl Bacterial Lipopeptide Protein Localization To Plasma Membrane Establishment Of Epithelial Cell Polarity Ruffle Assembly Hepatocyte Apoptotic Process Maintenance Of Postsynaptic Density Structure Positive Regulation Of Focal Adhesion Disassembly Erythrocyte Apoptotic Process Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Mitotic Cytokinetic Process Protein Localization To Cleavage Furrow Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Dendrite Development	Microtubule Cytoskeleton Organization Cell Projection Organization Positive Regulation Of Microtubule Polymerization Axoneme Assembly Cilium Assembly Non-motile Cilium Assembly
Pathways		TBC/RABGAPs Clathrin-mediated endocytosis MET receptor recycling	None
Drugs		5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate Myristic acid	None
GWAS		Erythema nodosum in inflammatory bowel disease ( 24487271 ) Ferritin levels ( 33491795 )	No GWAS studies recorded
Novel Interactors		7 novel interactors: ALDH5A1 LSM7 MGAM PRPF39 RPLP1 SMARCC2 TOGARAM1	1 novel interactors: ARF6
Interacting Genes		40 interacting genes: AGAP1 AP1B1 AP2B1 AP3B1 AP3D1 AP3S2 APP ARFIP2 ARHGAP10 ARRB1 ARRB2 ASAP1 ASAP2 ASAP3 ATP6V0C CAPN1 CHRM3 CLTC CYTH1 CYTH2 EXOC5 EZR FILNC1 HTR2A IKBKG ITSN1 MEOX2 MT2A PALS1 PIP5K1A PIP5K1C PLD1 RAB11A RAB11FIP3 RAB11FIP4 RAB11FIP5 SMAP1 SNCA SPAG9 ZNF709	1 interacting genes: SRPK2
Entrez ID		382	23116
HPRD ID		02714	11082
Ensembl ID		ENSG00000165527	ENSG00000198718
Uniprot IDs		P62330	B4DHM7 G3XAE9 Q6P183 Q9Y4F4
PDB IDs		1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX 6BBP 6BBQ 6PAU 7RK3 7XRD	Not available
GO Terms Enriched among Interactors		Vesicle-mediated Transport Cytoplasmic Vesicle Intracellular Protein Localization Membrane Coat Establishment Of Localization In Cell Trans-Golgi Network Membrane Receptor-mediated Endocytosis Endocytosis Receptor Internalization Clathrin-coated Pit Protein Transport Melanosome Assembly Vesicle-mediated Transport In Synapse Regulation Of Vesicle-mediated Transport Cellular Localization Cytoplasmic Vesicle Membrane Organelle Localization Establishment Of Vesicle Localization Platelet Dense Granule Organization Import Into Cell Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Golgi Membrane Establishment Of Protein Localization Vesicle Localization Clathrin-dependent Endocytosis Cellular Component Assembly Endocytic Vesicle Membrane Synaptic Vesicle Transport Melanosome Organization AP-3 Adaptor Complex Pigment Granule Organization Synaptic Vesicle Endocytosis Clathrin Adaptor Complex Positive Regulation Of Endocytosis GTPase Activator Activity Presynaptic Endocytosis Plasma Membrane Lysosomal Membrane Angiotensin Receptor Binding Golgi Apparatus Establishment Of Organelle Localization Secretion Post-Golgi Vesicle-mediated Transport Secretion By Cell Localization Within Membrane Intracellular Transport Regulation Of Cellular Component Organization Protein Localization To Plasma Membrane Anterograde Synaptic Vesicle Transport Focal Adhesion	Ruffle Assembly Positive Regulation Of Mitotic Cytokinesis Thioesterase Binding Response To Bacterial Lipoprotein Positive Regulation Of Keratinocyte Migration Presynapse Maintenance Of Postsynaptic Specialization Structure Positive Regulation Of Mitotic Cytokinetic Process Negative Regulation Of Protein Localization To Cell Surface Cellular Response To Diacyl Bacterial Lipopeptide Negative Regulation Of Dendrite Development Protein Localization To Cleavage Furrow Positive Regulation Of Focal Adhesion Disassembly Erythrocyte Apoptotic Process Cellular Response To Bacterial Lipopeptide Positive Regulation Of Cell Cycle Maintenance Of Postsynaptic Density Structure R-loop Processing Nuclear Speck Organization Regulation Of Mitotic Cytokinesis Protein Localization To Endosome Myeloid Cell Apoptotic Process Hepatocyte Apoptotic Process Filopodium Membrane Nuclear Body Organization Postsynaptic Density Organization Postsynaptic Specialization Organization Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Ruffle Organization Cortical Actin Cytoskeleton Organization Flemming Body Maintenance Of Synapse Structure Establishment Of Epithelial Cell Polarity Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Regulation Of Cell Cycle Negative Regulation Of Receptor-mediated Endocytosis 14-3-3 Protein Binding Positive Regulation Of Viral Genome Replication Presynaptic Endocytosis Vesicle Docking Involved In Exocytosis Response To Nerve Growth Factor Regulation Of Protein Localization To Cell Surface Cortical Cytoskeleton Organization Epithelial Cell Apoptotic Process Regulation Of Filopodium Assembly Synaptic Vesicle Endocytosis Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Cytokinesis