ARF6 and RAB11FIP3

Number of citations of the paper that reports this interaction (PubMedID 11535061)
0

Data Source:
HPRD (in vitro)

		ARF6	RAB11FIP3
Description		ARF GTPase 6	RAB11 family interacting protein 3
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Membrane Endocytic Vesicle Midbody Filopodium Membrane Early Endosome Membrane Cleavage Furrow Cell Projection Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Flemming Body Presynapse Postsynapse Glutamatergic Synapse	Golgi Membrane Nucleoplasm Cytoplasm Mitochondrion Endosome Golgi Apparatus Centrosome Cytosol Cytoskeleton Plasma Membrane Cilium Endosome Membrane Membrane Endocytic Vesicle Midbody Cytoplasmic Vesicle Membrane Endocytic Vesicle Membrane Cleavage Furrow Trans-Golgi Network Membrane Centriolar Satellite Ciliary Basal Body Intercellular Bridge Recycling Endosome Recycling Endosome Membrane Bounding Membrane Of Organelle Postsynaptic Recycling Endosome Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Thioesterase Binding Signaling Adaptor Activity	Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding GTPase Binding Dynein Light Intermediate Chain Binding Molecular Adaptor Activity
	Biological Process	Mitotic Cytokinesis Liver Development Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Cell Adhesion Nervous System Development Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Protein Transport Vesicle-mediated Transport Cell Differentiation Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Endocytic Recycling Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Protein Localization To Endosome Negative Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Protein Secretion Cell Division Regulation Of Filopodium Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Dendritic Spine Development Cellular Response To Diacyl Bacterial Lipopeptide Protein Localization To Plasma Membrane Establishment Of Epithelial Cell Polarity Ruffle Assembly Hepatocyte Apoptotic Process Maintenance Of Postsynaptic Density Structure Positive Regulation Of Focal Adhesion Disassembly Erythrocyte Apoptotic Process Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Mitotic Cytokinetic Process Protein Localization To Cleavage Furrow Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Dendrite Development	Mitotic Cytokinesis Vesicle Docking Involved In Exocytosis Microtubule-based Movement Vesicle-mediated Transport Endocytic Recycling Regulation Of Cytokinesis Golgi To Plasma Membrane Protein Transport Positive Regulation Of Cilium Assembly Cell Division Regulation Of Vesicle-mediated Transport Early Endosome To Recycling Endosome Transport Protein Localization To Cilium Negative Regulation Of Adiponectin Secretion Regulation Of Cilium Assembly Regulation Of Early Endosome To Recycling Endosome Transport Positive Regulation Of Mitotic Cytokinetic Process Regulation Of Protein Localization To Centrosome Protein Localization To Cleavage Furrow Regulation Of Endocytic Recycling
Pathways		TBC/RABGAPs Clathrin-mediated endocytosis MET receptor recycling	VxPx cargo-targeting to cilium
Drugs		5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate Myristic acid
Diseases
GWAS		Erythema nodosum in inflammatory bowel disease ( 24487271) Ferritin levels ( 33491795)	Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Heel bone mineral density ( 30598549) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494)
Interacting Genes		40 interacting genes: AGAP1 AP1B1 AP2B1 AP3B1 AP3D1 AP3S2 APP ARFIP2 ARHGAP10 ARRB1 ARRB2 ASAP1 ASAP2 ASAP3 ATP6V0C CAPN1 CHRM3 CLTC CYTH1 CYTH2 EXOC5 EZR FILNC1 HTR2A IKBKG ITSN1 MEOX2 MT2A PALS1 PIP5K1A PIP5K1C PLD1 RAB11A RAB11FIP3 RAB11FIP4 RAB11FIP5 SMAP1 SNCA SPAG9 ZNF709	9 interacting genes: ARF4 ARF5 ARF6 ASAP1 RAB11A RAB11B RAB11FIP4 RAB25 TOMM34
Entrez ID		382	9727
HPRD ID		02714	18521
Ensembl ID		ENSG00000165527	ENSG00000090565
Uniprot IDs		P62330	O75154
PDB IDs		1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX 6BBP 6BBQ 6PAU 7RK3 7XRD	2D7C 2HV8 4D0M 4UJ3 4UJ4
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Cytoplasmic Vesicle Intracellular Protein Localization Membrane Coat Establishment Of Localization In Cell Trans-Golgi Network Membrane Receptor-mediated Endocytosis Endocytosis Receptor Internalization Clathrin-coated Pit Protein Transport Melanosome Assembly Vesicle-mediated Transport In Synapse Regulation Of Vesicle-mediated Transport Cellular Localization Cytoplasmic Vesicle Membrane Organelle Localization Establishment Of Vesicle Localization Platelet Dense Granule Organization Import Into Cell Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Golgi Membrane Establishment Of Protein Localization Vesicle Localization Clathrin-dependent Endocytosis Cellular Component Assembly Endocytic Vesicle Membrane Synaptic Vesicle Transport Melanosome Organization AP-3 Adaptor Complex Pigment Granule Organization Synaptic Vesicle Endocytosis Clathrin Adaptor Complex Positive Regulation Of Endocytosis GTPase Activator Activity Presynaptic Endocytosis Plasma Membrane Lysosomal Membrane Angiotensin Receptor Binding Golgi Apparatus Establishment Of Organelle Localization Secretion Post-Golgi Vesicle-mediated Transport Secretion By Cell Localization Within Membrane Intracellular Transport Regulation Of Cellular Component Organization Protein Localization To Plasma Membrane Anterograde Synaptic Vesicle Transport Focal Adhesion	GTPase Activity GTP Binding Protein Localization To Cilium Golgi Apparatus G Protein Activity Endocytic Recycling Myosin V Binding Recycling Endosome Membrane Intracellular Protein Localization Vesicle-mediated Transport Intracellular Transport Vesicle-mediated Transport To The Plasma Membrane Recycling Endosome Protein Localization To Cleavage Furrow Establishment Of Protein Localization Positive Regulation Of Epithelial Cell Migration Plasma Membrane Bounded Cell Projection Organization Cleavage Furrow Cellular Localization Establishment Of Localization In Cell Regulation Of Cell Projection Assembly Positive Regulation Of Mitotic Cytokinetic Process Amyloid-beta Clearance By Transcytosis Regulation Of Epithelial Cell Migration Protein Transport Endosomal Transport Cell Projection Organization Regulation Of Cytokinesis Protein Localization To Organelle Regulation Of Cilium Assembly Positive Regulation Of Mitotic Cytokinesis Regulation Of Mitotic Cytokinesis Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Transcytosis Regulation Of Endocytic Recycling Melanosome Transport Establishment Of Melanosome Localization Pigment Granule Transport Melanosome Localization Pigment Granule Localization Amyloid-beta Clearance Regulation Of Cell Division Protein Localization To Cell Surface Nucleotide Binding Localization Within Membrane Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Exocytosis Regulation Of Protein Localization To Cell Surface
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