ARF6 and AP3S2

Number of citations: 78 (PubMedID 35844135)
Data Source: BioGRID (pull down, proximity labelling technology)

		ARF6	AP3S2
Name		ARF GTPase 6	adaptor related protein complex 3 subunit sigma 2
Structure			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Membrane Endocytic Vesicle Midbody Filopodium Membrane Early Endosome Membrane Cleavage Furrow Cell Projection Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Flemming Body Presynapse Postsynapse Glutamatergic Synapse	Early Endosome Golgi Apparatus Synaptic Vesicle Membrane Membrane Coat AP-3 Adaptor Complex Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Axon Cytoplasm
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Thioesterase Binding Signaling Adaptor Activity	None
	Biological Process	Mitotic Cytokinesis Liver Development Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Cell Adhesion Nervous System Development Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Protein Transport Vesicle-mediated Transport Cell Differentiation Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Endocytic Recycling Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Protein Localization To Endosome Negative Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Protein Secretion Cell Division Regulation Of Filopodium Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Dendritic Spine Development Cellular Response To Diacyl Bacterial Lipopeptide Protein Localization To Plasma Membrane Establishment Of Epithelial Cell Polarity Ruffle Assembly Hepatocyte Apoptotic Process Maintenance Of Postsynaptic Density Structure Positive Regulation Of Focal Adhesion Disassembly Erythrocyte Apoptotic Process Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Mitotic Cytokinetic Process Protein Localization To Cleavage Furrow Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Dendrite Development	Intracellular Protein Transport Golgi To Vacuole Transport Anterograde Axonal Transport Protein Transport Synaptic Vesicle Coating Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Synaptic Vesicle Recycling Anterograde Synaptic Vesicle Transport Platelet Dense Granule Organization Melanosome Assembly
Pathways		TBC/RABGAPs Clathrin-mediated endocytosis MET receptor recycling	None
Drugs		5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate Myristic acid	None
GWAS		Erythema nodosum in inflammatory bowel disease ( 24487271 ) Ferritin levels ( 33491795 )	Type 2 diabetes ( 21874001 23945395 24509480 28869590 29358691 30054458 30297969 30718926 32499647 ) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408 )
Novel Interactors		7 novel interactors: ALDH5A1 LSM7 MGAM PRPF39 RPLP1 SMARCC2 TOGARAM1	None recorded
Interacting Genes		40 interacting genes: AGAP1 AP1B1 AP2B1 AP3B1 AP3D1 AP3S2 APP ARFIP2 ARHGAP10 ARRB1 ARRB2 ASAP1 ASAP2 ASAP3 ATP6V0C CAPN1 CHRM3 CLTC CYTH1 CYTH2 EXOC5 EZR FILNC1 HTR2A IKBKG ITSN1 MEOX2 MT2A PALS1 PIP5K1A PIP5K1C PLD1 RAB11A RAB11FIP3 RAB11FIP4 RAB11FIP5 SMAP1 SNCA SPAG9 ZNF709	7 interacting genes: AP3B1 AP3D1 AP3S1 ARF1 ARF6 E2F4 SCARB2
Entrez ID		382	10239
HPRD ID		02714	03880
Ensembl ID		ENSG00000165527	ENSG00000157823
Uniprot IDs		P62330	P59780
PDB IDs		1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX 6BBP 6BBQ 6PAU 7RK3 7XRD	Not available
GO Terms Enriched among Interactors		Vesicle-mediated Transport Cytoplasmic Vesicle Intracellular Protein Localization Membrane Coat Establishment Of Localization In Cell Trans-Golgi Network Membrane Receptor-mediated Endocytosis Endocytosis Receptor Internalization Clathrin-coated Pit Protein Transport Melanosome Assembly Vesicle-mediated Transport In Synapse Regulation Of Vesicle-mediated Transport Cellular Localization Cytoplasmic Vesicle Membrane Organelle Localization Establishment Of Vesicle Localization Platelet Dense Granule Organization Import Into Cell Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Golgi Membrane Establishment Of Protein Localization Vesicle Localization Clathrin-dependent Endocytosis Cellular Component Assembly Endocytic Vesicle Membrane Synaptic Vesicle Transport Melanosome Organization AP-3 Adaptor Complex Pigment Granule Organization Synaptic Vesicle Endocytosis Clathrin Adaptor Complex Positive Regulation Of Endocytosis GTPase Activator Activity Presynaptic Endocytosis Plasma Membrane Lysosomal Membrane Angiotensin Receptor Binding Golgi Apparatus Establishment Of Organelle Localization Secretion Post-Golgi Vesicle-mediated Transport Secretion By Cell Localization Within Membrane Intracellular Transport Regulation Of Cellular Component Organization Protein Localization To Plasma Membrane Anterograde Synaptic Vesicle Transport Focal Adhesion	Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Intracellular Protein Transport AP-3 Adaptor Complex Anterograde Synaptic Vesicle Transport Melanosome Assembly Platelet Dense Granule Organization Membrane Coat Vesicle Cargo Loading Vacuolar Transport Synaptic Vesicle Transport Melanosome Organization Pigment Granule Organization Protein Transport Vesicle-mediated Transport Vesicle Transport Along Microtubule Anterograde Axonal Transport Intracellular Transport Protein Targeting To Vacuole Positive Regulation Of NK T Cell Differentiation Establishment Of Protein Localization Vesicle Cytoskeletal Trafficking Protein Localization To Lysosome Synaptic Vesicle Coating Axon Cytoplasm Establishment Of Protein Localization To Vacuole Axonal Transport Secretory Granule Organization Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Regulation Of NK T Cell Differentiation Cellular Localization Establishment Of Localization In Cell Axo-dendritic Transport Early Endosome Organelle Transport Along Microtubule Protein Localization To Vacuole Intracellular Protein Localization Establishment Of Vesicle Localization Vesicle Localization Lysosomal Transport Synaptic Vesicle Recycling Organelle Localization Golgi To Vacuole Transport Localization Within Membrane Transport Along Microtubule Golgi Apparatus Cytoskeleton-dependent Intracellular Transport Protein Targeting Protein Localization To Organelle Protein Localization To Cell Surface Protein Targeting To Lysosome