TNFAIP3 and YWHAQ

Number of citations of the paper that reports this interaction (PubMedID 25165885)
37

Data Source:
BioGRID (two hybrid)

		TNFAIP3	YWHAQ
Description		TNF alpha induced protein 3	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
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GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Cytosol Extracellular Exosome	Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Protein-containing Complex Synapse Extracellular Exosome
	Molecular Function	Protease Binding DNA Binding Catalytic Activity Ubiquitin-protein Transferase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Transferase Activity Hydrolase Activity Enzyme Binding Kinase Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding K63-linked Deubiquitinase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Binding Protein Domain Specific Binding Identical Protein Binding Transmembrane Transporter Binding 14-3-3 Protein Binding
	Biological Process	B-1 B Cell Homeostasis Response To Molecule Of Bacterial Origin Immune System Process Regulation Of Germinal Center Formation Negative Regulation Of Chronic Inflammatory Response Proteolysis Apoptotic Process Inflammatory Response Cytoskeleton Organization Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cell Migration Protein Deubiquitination Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Ubiquitination Response To Muramyl Dipeptide Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Protein K11-linked Deubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Catabolic Process Negative Regulation Of Bone Resorption Negative Regulation Of Innate Immune Response Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Defense Response To Virus By Host Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Activation Regulation Of Vascular Wound Healing Cellular Response To Hydrogen Peroxide Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Protein K48-linked Deubiquitination Cellular Response To Lipopolysaccharide Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Tolerance Induction To Lipopolysaccharide Establishment Of Protein Localization To Vacuole Negative Regulation Of Osteoclast Proliferation Cellular Response To Oxygen-containing Compound Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of CD40 Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Targeting Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Protein Localization Substantia Nigra Development Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of DNA-templated Transcription
Pathways		NOD1/2 Signaling Pathway TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ovarian tumor domain proteases Negative regulators of DDX58/IFIH1 signaling	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Autoimmune traits (pleiotropy) ( 30572963) Cardiac Troponin-T levels ( 23247143) Celiac disease ( 20190752 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cutaneous psoriasis ( 26626624) Hodgkin's lymphoma ( 30194254) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Malaria ( 31844061) Multiple sclerosis ( 24076602) Phosphatidylcholine-ether levels ( 31551469) Primary biliary cholangitis ( 26394269) Psoriasis ( 25574825 19169254 25903422 20953190 23143594) Psoriasis vulgaris ( 26626624) Rheumatoid arthritis ( 24449572 24390342 23143596 20453841 32723749 30423114 17982456) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Sjögren's syndrome ( 24097066 24097067) Systemic lupus erythematosus ( 19165918 28714469 27399966 26663301 26502338 23273568 19838195 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 28314753) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Tonsillectomy ( 28928442 27182965) Type 1 diabetes ( 34127860)	Heart rate variability traits ( 22174390) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933)
Interacting Genes		61 interacting genes: ANKRD13D ARRDC3 ATP2A2 CALCOCO2 CCDC50 CCDC90B CHUK CLEC4G COL1A1 DRC4 FABP4 GIT2 GNAI2 IKBKB IKBKG LAPTM5 LNX1 MAP3K5 OCLN PCBP1 PFKL PIBF1 PSMA7 RAD23A RBCK1 RIPK1 RLIM RNF11 RNF14 RNF168 RNF216 RNF5 RPS15 RPS20 SNAI1 TAX1BP1 TICAM1 TIFA TNIP1 TNIP2 TRAF1 TRAF2 TRAF6 TRIM2 TRIM23 TRIM3 TRIM5 TRIM8 UBC UBE2D1 UBE2N UBQLN1 UBXN6 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZFAND5 ZNF251	216 interacting genes: AARS2 ABL1 ACSL4 ADRB2 AGTR1 AHCY AKT1S1 ANXA1 ANXA2 AR ARHGAP10 ARHGEF16 ATP5F1A BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CCDC125 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDKN1A CDKN1B CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EGFR EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1 H2BC8 H4C14 HADHA HAT1 HAX1 HDAC7 HNRNPC HNRNPH1 HSPA1A HSPA8 HSPB1 HUS1 IARS2 ING1 ITCH ITGB4 KANK1 KCNK15 KCNK3 KCNK9 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LYST MAGOH MAP3K3 MAP3K5 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NEDD4L NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPN1 PANK1 PDCD6 PDE3A PDE3B PDE4B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C3 PIK3CB PKM PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RIPK2 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SKIC8 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SOCS3 SPR SPTA1 SPTB SRSF3 SSBP1 SSX2IP SUMO2 TCP1 TERT THRA TLN1 TNF TNFAIP3 TPI1 TPR TRAF6 TRIM25 TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBQLN4 UCP2 UCP3 ULK4 USP8 VARS1 WDR77 WTAP WWC2 WWP1 YAP1 YWHAG ZC3H13 ZHX2
Entrez ID		7128	10971
HPRD ID		01857	00886
Ensembl ID		ENSG00000118503	ENSG00000134308
Uniprot IDs		P21580	P27348
PDB IDs		2EQE 2EQF 2EQG 2VFJ 3DKB 3OJ3 3OJ4 3VUW 3VUX 3VUY 3ZJD 3ZJE 3ZJF 3ZJG 5LRX 5V3B 5V3P	2BTP 5IQP 6BCR 6BD2 6BQT 6KZG 6KZH
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Regulation Of Canonical NF-kappaB Signal Transduction Post-translational Protein Modification Ubiquitin Protein Ligase Activity Regulation Of Intracellular Signal Transduction Ubiquitin-protein Transferase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Modification-dependent Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteolysis Involved In Protein Catabolic Process Regulation Of Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Ubiquitin-dependent Protein Catabolic Process Cytoplasm Positive Regulation Of Intracellular Signal Transduction Macromolecule Catabolic Process Regulation Of Immune Response Protein Modification Process Cytosol Activation Of Innate Immune Response Activation Of Immune Response Protein K63-linked Ubiquitination Immune Response-activating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Signaling Adaptor Activity Protein Metabolic Process Positive Regulation Of Signal Transduction Identical Protein Binding Catabolic Process Innate Immune Response-activating Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Immune Response Positive Regulation Of Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Innate Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Defense Response Protein Sequestering Activity Positive Regulation Of Innate Immune Response Positive Regulation Of Immune System Process Proteasomal Protein Catabolic Process Cell Surface Toll-like Receptor Signaling Pathway	Cytosol Cytoplasm Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process ATP Binding Regulation Of Cellular Component Organization Regulation Of Primary Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Metabolic Process Nucleus Cadherin Binding Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Developmental Process Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Nucleotide Binding Regulation Of Biological Quality Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cortex Cellular Response To Oxygen-containing Compound Response To Stress Protein-containing Complex Glucose Catabolic Process Organelle Organization Positive Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process ADP Metabolic Process RNA Binding Cellular Response To Lipid Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Exosome Regulation Of Organelle Organization Positive Regulation Of Cell Population Proliferation Glycolytic Process Cellular Response To Hormone Stimulus
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