TNFAIP3 and TIFA

Number of citations of the paper that reports this interaction (PubMedID 35089437)
43

Data Source:
BioGRID (pull down, pull down)

		TNFAIP3	TIFA
Description		TNF alpha induced protein 3	TRAF interacting protein with forkhead associated domain
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GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Cytosol Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	Protease Binding DNA Binding Catalytic Activity Ubiquitin-protein Transferase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Transferase Activity Hydrolase Activity Enzyme Binding Kinase Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding K63-linked Deubiquitinase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Binding
	Biological Process	B-1 B Cell Homeostasis Response To Molecule Of Bacterial Origin Immune System Process Regulation Of Germinal Center Formation Negative Regulation Of Chronic Inflammatory Response Proteolysis Apoptotic Process Inflammatory Response Cytoskeleton Organization Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cell Migration Protein Deubiquitination Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Ubiquitination Response To Muramyl Dipeptide Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Protein K11-linked Deubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Catabolic Process Negative Regulation Of Bone Resorption Negative Regulation Of Innate Immune Response Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Defense Response To Virus By Host Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Activation Regulation Of Vascular Wound Healing Cellular Response To Hydrogen Peroxide Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Protein K48-linked Deubiquitination Cellular Response To Lipopolysaccharide Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Tolerance Induction To Lipopolysaccharide Establishment Of Protein Localization To Vacuole Negative Regulation Of Osteoclast Proliferation Cellular Response To Oxygen-containing Compound Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of CD40 Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein Homooligomerization
Pathways		NOD1/2 Signaling Pathway TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ovarian tumor domain proteases Negative regulators of DDX58/IFIH1 signaling	TAK1-dependent IKK and NF-kappa-B activation Alpha-protein kinase 1 signaling pathway
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Autoimmune traits (pleiotropy) ( 30572963) Cardiac Troponin-T levels ( 23247143) Celiac disease ( 20190752 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cutaneous psoriasis ( 26626624) Hodgkin's lymphoma ( 30194254) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Malaria ( 31844061) Multiple sclerosis ( 24076602) Phosphatidylcholine-ether levels ( 31551469) Primary biliary cholangitis ( 26394269) Psoriasis ( 25574825 19169254 25903422 20953190 23143594) Psoriasis vulgaris ( 26626624) Rheumatoid arthritis ( 24449572 24390342 23143596 20453841 32723749 30423114 17982456) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Sjögren's syndrome ( 24097066 24097067) Systemic lupus erythematosus ( 19165918 28714469 27399966 26663301 26502338 23273568 19838195 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 28314753) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Tonsillectomy ( 28928442 27182965) Type 1 diabetes ( 34127860)	Body mass index ( 26426971) Rheumatoid arthritis ( 30891314)
Interacting Genes		61 interacting genes: ANKRD13D ARRDC3 ATP2A2 CALCOCO2 CCDC50 CCDC90B CHUK CLEC4G COL1A1 DRC4 FABP4 GIT2 GNAI2 IKBKB IKBKG LAPTM5 LNX1 MAP3K5 OCLN PCBP1 PFKL PIBF1 PSMA7 RAD23A RBCK1 RIPK1 RLIM RNF11 RNF14 RNF168 RNF216 RNF5 RPS15 RPS20 SNAI1 TAX1BP1 TICAM1 TIFA TNIP1 TNIP2 TRAF1 TRAF2 TRAF6 TRIM2 TRIM23 TRIM3 TRIM5 TRIM8 UBC UBE2D1 UBE2N UBQLN1 UBXN6 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZFAND5 ZNF251	25 interacting genes: ALPK1 AP1M1 ARHGEF39 DVL2 GSDME IRAK1 KANK2 LNX1 LNX2 NIF3L1 NTAQ1 NUDT18 NXF1 PRKAA2 RIPPLY3 RPL9 SDCBP SDCBP2 TIFAB TNFAIP3 TNFAIP8 TRAF1 TRAF2 TRAF6 TXN2
Entrez ID		7128	92610
HPRD ID		01857	09835
Ensembl ID		ENSG00000118503	ENSG00000145365
Uniprot IDs		P21580	Q96CG3
PDB IDs		2EQE 2EQF 2EQG 2VFJ 3DKB 3OJ3 3OJ4 3VUW 3VUX 3VUY 3ZJD 3ZJE 3ZJF 3ZJG 5LRX 5V3B 5V3P	4YM4 4ZGI 5ZUJ 6A33
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Regulation Of Canonical NF-kappaB Signal Transduction Post-translational Protein Modification Ubiquitin Protein Ligase Activity Regulation Of Intracellular Signal Transduction Ubiquitin-protein Transferase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Modification-dependent Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteolysis Involved In Protein Catabolic Process Regulation Of Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Ubiquitin-dependent Protein Catabolic Process Cytoplasm Positive Regulation Of Intracellular Signal Transduction Macromolecule Catabolic Process Regulation Of Immune Response Protein Modification Process Cytosol Activation Of Innate Immune Response Activation Of Immune Response Protein K63-linked Ubiquitination Immune Response-activating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Signaling Adaptor Activity Protein Metabolic Process Positive Regulation Of Signal Transduction Identical Protein Binding Catabolic Process Innate Immune Response-activating Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Immune Response Positive Regulation Of Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Innate Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Defense Response Protein Sequestering Activity Positive Regulation Of Innate Immune Response Positive Regulation Of Immune System Process Proteasomal Protein Catabolic Process Cell Surface Toll-like Receptor Signaling Pathway	Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Innate Immune Response-activating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Identical Protein Binding Cytoplasmic Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Tumor Necrosis Factor Receptor Binding Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Lipopolysaccharide-mediated Signaling Pathway Ubiquitin-protein Transferase Activity Positive Regulation Of Immune Response Positive Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of JNK Cascade Interleukin-33-mediated Signaling Pathway Positive Regulation Of Innate Immune Response Tumor Necrosis Factor-mediated Signaling Pathway Thioesterase Binding CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Interleukin-2 Production CD40 Receptor Complex Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Regulation Of Programmed Cell Death Immune Response-activating Signaling Pathway Phosphatidylinositol-4,5-bisphosphate Binding Signaling Adaptor Activity Regulation Of Apoptotic Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cell Death Programmed Cell Death Immune Response-regulating Signaling Pathway Intracellular Receptor Signaling Pathway Activation Of Immune Response Regulation Of Immune Response Regulation Of Innate Immune Response Positive Regulation Of JNK Cascade Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Defense Response Positive Regulation Of Immune System Process Regulation Of Signal Transduction Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
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