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TNFAIP3 and TRAF1
Number of citations of the paper that reports this interaction (PubMedID
8692885
)
28
Data Source:
HPRD
(two hybrid, in vivo)
TNFAIP3
TRAF1
Description
TNF alpha induced protein 3
TNF receptor associated factor 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lysosome
Cytosol
Extracellular Exosome
Cytoplasm
Cytosol
Molecular Function
Protease Binding
DNA Binding
Catalytic Activity
Ubiquitin-protein Transferase Activity
Cysteine-type Deubiquitinase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Zinc Ion Binding
Transferase Activity
Hydrolase Activity
Enzyme Binding
Kinase Binding
Identical Protein Binding
Ubiquitin Binding
Metal Ion Binding
K63-linked Deubiquitinase Activity
K63-linked Polyubiquitin Modification-dependent Protein Binding
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Signaling Adaptor Activity
Identical Protein Binding
Biological Process
B-1 B Cell Homeostasis
Response To Molecule Of Bacterial Origin
Immune System Process
Regulation Of Germinal Center Formation
Negative Regulation Of Chronic Inflammatory Response
Proteolysis
Apoptotic Process
Inflammatory Response
Cytoskeleton Organization
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Cell Migration
Protein Deubiquitination
Positive Regulation Of Wnt Signaling Pathway
Negative Regulation Of Protein Ubiquitination
Response To Muramyl Dipeptide
Negative Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Interleukin-2 Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Toll-like Receptor 2 Signaling Pathway
Negative Regulation Of Toll-like Receptor 3 Signaling Pathway
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Toll-like Receptor 5 Signaling Pathway
Protein K11-linked Deubiquitination
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Bone Resorption
Negative Regulation Of Innate Immune Response
Negative Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Defense Response To Virus By Host
Negative Regulation Of Inflammatory Response
Negative Regulation Of B Cell Activation
Regulation Of Vascular Wound Healing
Cellular Response To Hydrogen Peroxide
Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Protein K63-linked Deubiquitination
Protein K48-linked Ubiquitination
Protein K48-linked Deubiquitination
Cellular Response To Lipopolysaccharide
Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Tolerance Induction To Lipopolysaccharide
Establishment Of Protein Localization To Vacuole
Negative Regulation Of Osteoclast Proliferation
Cellular Response To Oxygen-containing Compound
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Hepatocyte Proliferation
Negative Regulation Of CD40 Signaling Pathway
Negative Regulation Of Endothelial Cell Apoptotic Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Apoptotic Process
Signal Transduction
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein-containing Complex Assembly
Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
NOD1/2 Signaling Pathway
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
Ovarian tumor domain proteases
Negative regulators of DDX58/IFIH1 signaling
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
Drugs
Diseases
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
32296059
)
Autoimmune traits (pleiotropy) (
30572963
)
Cardiac Troponin-T levels (
23247143
)
Celiac disease (
20190752
22057235
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Cutaneous psoriasis (
26626624
)
Hodgkin's lymphoma (
30194254
)
Inflammatory bowel disease (
23128233
)
Inflammatory skin disease (
25574825
)
Malaria (
31844061
)
Multiple sclerosis (
24076602
)
Phosphatidylcholine-ether levels (
31551469
)
Primary biliary cholangitis (
26394269
)
Psoriasis (
25574825
19169254
25903422
20953190
23143594
)
Psoriasis vulgaris (
26626624
)
Rheumatoid arthritis (
24449572
24390342
23143596
20453841
32723749
30423114
17982456
)
Rheumatoid arthritis (ACPA-positive) (
24532676
23143596
)
Sjögren's syndrome (
24097066
24097067
)
Systemic lupus erythematosus (
19165918
28714469
27399966
26663301
26502338
23273568
19838195
19838193
)
Systemic lupus erythematosus and Systemic sclerosis (
23740937
)
Systemic lupus erythematosus or rheumatoid arthritis (
27193031
)
Systemic sclerosis (
28314753
)
Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) (
30573655
)
Tonsillectomy (
28928442
27182965
)
Type 1 diabetes (
34127860
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
32296059
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Eosinophil percentage of white cells (
32888494
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Pulse pressure (
30578418
)
Refractive error (
32231278
)
Rheumatoid arthritis (
24390342
24782177
23143596
30891314
19503088
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
White blood cell count (
32888494
)
Interacting Genes
61 interacting genes:
ANKRD13D
ARRDC3
ATP2A2
CALCOCO2
CCDC50
CCDC90B
CHUK
CLEC4G
COL1A1
DRC4
FABP4
GIT2
GNAI2
IKBKB
IKBKG
LAPTM5
LNX1
MAP3K5
OCLN
PCBP1
PFKL
PIBF1
PSMA7
RAD23A
RBCK1
RIPK1
RLIM
RNF11
RNF14
RNF168
RNF216
RNF5
RPS15
RPS20
SNAI1
TAX1BP1
TICAM1
TIFA
TNIP1
TNIP2
TRAF1
TRAF2
TRAF6
TRIM2
TRIM23
TRIM3
TRIM5
TRIM8
UBC
UBE2D1
UBE2N
UBQLN1
UBXN6
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZFAND5
ZNF251
244 interacting genes:
A1CF
ABHD17A
ACTN3
AIRIM
AKAP17A
AQP1
ARID5A
ARNT2
ARSJ
BARD1
BCAS2
BCL6
BEX2
BEX3
BIRC2
BIRC3
C1orf216
CARHSP1
CASP10
CASP3
CASP6
CASP8
CATSPERT
CCDC116
CCDC120
CCDC146
CCDC185
CCDC187
CCDC198
CCHCR1
CD40
CDCA3
CDK18
CDKN1A
CDKN2B
CFLAR
CHCHD3
COX5B
CRACR2A
CRY2
CRYGA
CYB5R2
DEPTOR
DGCR6
DMRT3
DOK3
DUSP13B
DUSP21
DUSP4
EBF2
EDAR
EHHADH
ENKD1
EWSR1
FAM161A
FAM161B
FAM86C1P
FBF1
FBXL18
FOSL2
GADD45GIP1
GATA1
GATA2
GATAD2B
GCA
GCM2
GEM
GFI1B
GIT2
GLIS3
GLRX3
GMCL2
GNG5
GOLGA2
GORASP2
GRAP2
HAUS1
HELT
HEY2
HGS
HIVEP3
HMG20B
HNRNPM
HOXA1
HOXB5
HOXC8
HOXD12
IKBKB
JOSD1
KANK2
KIAA1217
KIF1A
KLHL38
KPNA2
KRT3
KRT75
LCOR
LIN37
LMNTD2
LNX1
LNX2
LRRN1
LTBR
MACIR
MAP3K14
MAP6
MAPRE2
MATR3
METTL17
MORN3
MOS
MSGN1
MYEF2
MYOZ1
NEBL
NOL4L-DT
NTAQ1
NUFIP2
NUP58
OLIG3
PATZ1
PBX3
PDE4D
PHF21A
PIN1
PITX1
PITX2
PKN1
PLAC8
PLEKHN1
POM121L4P
POP5
PPP1R13B
PRDM7
PRKAB2
PSMA1
PSMB1
QRICH1
RASAL2
RASSF5
RBCK1
RBM41
RBM45
RCOR3
RIIAD1
RIPK1
RIPK2
RIPOR3
RIPPLY1
RNF31
RTP5
SAMD11
SAXO4
SCNM1
SDCBP2
SH3GLB2
SHARPIN
SHC3
SHFL
SIK3
SLC25A48
SLC25A6
SNRNP25
SNW1
SOHLH1
SPATA46
SPG21
SPMIP2
SPOP
SRC
SSC5D
STK3
SUMO2
SYCE1
TANK
TBC1D16
TBC1D8
TBX18
TCEA2
TCF7L2
TCL1A
TEAD4
TFAP2D
TFAP4
TFPT
THAP7
TICAM1
TIFA
TLE5
TNFAIP3
TNFRSF11A
TNFRSF12A
TNFRSF14
TNFRSF17
TNFRSF18
TNFRSF19
TNFRSF1A
TNFRSF1B
TNFRSF4
TNFRSF8
TNFRSF9
TNFSF9
TRADD
TRAF2
TRAF3IP2
TRAF6
TRAIP
TRIM23
TRIM37
TRIM42
TRPV6
TSHZ2
TSSC4
USP2
USP7
UTP14C
VEZF1
WAC
ZBTB1
ZBTB16
ZC2HC1C
ZFYVE21
ZFYVE26
ZIC1
ZNF124
ZNF20
ZNF23
ZNF250
ZNF417
ZNF440
ZNF490
ZNF502
ZNF512B
ZNF564
ZNF572
ZNF581
ZNF587
ZNF627
ZNF648
ZNF662
ZNF669
ZNF688
ZNF697
ZNF844
Entrez ID
7128
7185
HPRD ID
01857
03418
Ensembl ID
ENSG00000118503
ENSG00000056558
Uniprot IDs
P21580
Q13077
PDB IDs
2EQE
2EQF
2EQG
2VFJ
3DKB
3OJ3
3OJ4
3VUW
3VUX
3VUY
3ZJD
3ZJE
3ZJF
3ZJG
5LRX
5V3B
5V3P
3M0D
5E1T
5H10
Enriched GO Terms of Interacting Partners
?
Protein Ubiquitination
Protein Polyubiquitination
Protein Modification By Small Protein Conjugation
Regulation Of Canonical NF-kappaB Signal Transduction
Post-translational Protein Modification
Ubiquitin Protein Ligase Activity
Regulation Of Intracellular Signal Transduction
Ubiquitin-protein Transferase Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Modification-dependent Protein Catabolic Process
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Proteolysis Involved In Protein Catabolic Process
Regulation Of Signal Transduction
Positive Regulation Of DNA-binding Transcription Factor Activity
Ubiquitin-dependent Protein Catabolic Process
Cytoplasm
Positive Regulation Of Intracellular Signal Transduction
Macromolecule Catabolic Process
Regulation Of Immune Response
Protein Modification Process
Cytosol
Activation Of Innate Immune Response
Activation Of Immune Response
Protein K63-linked Ubiquitination
Immune Response-activating Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Signaling Adaptor Activity
Protein Metabolic Process
Positive Regulation Of Signal Transduction
Identical Protein Binding
Catabolic Process
Innate Immune Response-activating Signaling Pathway
Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Immune Response
Positive Regulation Of Metabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
Immune Response-regulating Signaling Pathway
Protein Catabolic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Innate Immune Response
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Defense Response
Protein Sequestering Activity
Positive Regulation Of Innate Immune Response
Positive Regulation Of Immune System Process
Proteasomal Protein Catabolic Process
Cell Surface Toll-like Receptor Signaling Pathway
Tumor Necrosis Factor-mediated Signaling Pathway
Protein Binding
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Tumor Necrosis Factor Receptor Activity
Zinc Ion Binding
Regulation Of Metabolic Process
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Non-canonical NF-kappaB Signal Transduction
Nucleus
DNA Binding
Ripoptosome
CD40 Receptor Complex
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of Necroptotic Process
Death-inducing Signaling Complex
Apoptotic Process
Regulation Of Programmed Cell Death
Tumor Necrosis Factor Receptor Superfamily Complex
Regulation Of Programmed Necrotic Cell Death
Programmed Cell Death
Cell Death
CD40 Signaling Pathway
Positive Regulation Of Programmed Cell Death
Cytokine-mediated Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Necroptotic Process
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Programmed Necrotic Cell Death
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of RNA Metabolic Process
Identical Protein Binding
Apoptotic Signaling Pathway
Sequence-specific Double-stranded DNA Binding
Protein Linear Polyubiquitination
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Canonical NF-kappaB Signal Transduction
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Death Receptor Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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