TNFAIP3 and RNF11

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (in vivo, two hybrid)

		TNFAIP3	RNF11
Gene Name		tumor necrosis factor, alpha-induced protein 3	ring finger protein 11
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Centrosome Cytosol Extracellular Vesicular Exosome	Ubiquitin Ligase Complex Nucleus Early Endosome Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	Protease Binding DNA Binding Ubiquitin-protein Transferase Activity Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Ligase Activity Kinase Binding Ubiquitin Binding Protein Self-association	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding
	Biological Process	B-1 B Cell Homeostasis Response To Molecule Of Bacterial Origin Regulation Of Germinal Center Formation Negative Regulation Of Chronic Inflammatory Response Proteolysis Apoptotic Process Inflammatory Response Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Response To Muramyl Dipeptide Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Protein K11-linked Deubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Bone Resorption Negative Regulation Of Innate Immune Response Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Defense Response To Virus By Host Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Activation Protein Oligomerization Regulation Of Vascular Wound Healing Cellular Response To Hydrogen Peroxide Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Protein K48-linked Deubiquitination Cellular Response To Lipopolysaccharide Tolerance Induction To Lipopolysaccharide Establishment Of Protein Localization To Vacuole Negative Regulation Of Osteoclast Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of CD40 Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Innate Immune System
Drugs
Diseases
GWAS		Cardiac Troponin-T levels ( 23247143) Celiac disease ( 20190752) Inflammatory bowel disease ( 23128233) Psoriasis ( 20953190 19169254) Rheumatoid arthritis ( 20453841 20453842 17982456) Systemic lupus erythematosus ( 23273568 19165918 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)	Ventricular conduction ( 21076409)
Protein-Protein Interactions		38 interactors: ARRDC3 CCDC50 CHUK GIT2 IKBKB IKBKG LAPTM5 OCLN RBCK1 RIPK1 RLIM RNF11 RNF14 RNF5 TAX1BP1 TICAM1 TNF TNIP1 TNIP2 TNIP3 TRAF1 TRAF2 TRAF6 TRIM2 TRIM23 TRIM3 TRIM5 TRIM8 UBC UBE2D1 UBE2N YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZFAND5	68 interactors: AKT1 ANKRD13A APP ASCC2 AUP1 CALCOCO2 CBLB CCDC127 DCUN1D1 EPN1 EPN2 EPN3 EPS15 ERCC6 GGA1 GGA2 GGA3 HERC1 HERC2 HUWE1 IKBKG ITCH MYO6 NEDD4 NEDD4L OPTN PDCD6IP POLI PTPRC QARS RABGEF1 RIPK1 RNF168 RNF216 RPS27A SDCBP SMURF1 SMURF2 SNRNP70 SPRTN STAM2 STAMBP STAMBPL1 TAX1BP1 TNFAIP3 TNIP1 TOM1L2 UBA52 UBAC1 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBQLN2 UBQLN4 USP5 WWP1 WWP2 ZFYVE16 ZFYVE9 ZNF350
Entrez ID		7128	26994
HPRD ID		01857	09955
Ensembl ID		ENSG00000118503	ENSG00000123091
Uniprot IDs		P21580	Q9Y3C5
PDB IDs		2EQE 2EQF 2EQG 2VFJ 3DKB 3OJ3 3OJ4 3VUW 3VUX 3VUY 3ZJD 3ZJE 3ZJF 3ZJG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Innate Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Regulation Of Signaling Regulation Of Immune Response Protein Ubiquitination Protein Modification By Small Protein Conjugation Defense Response Apoptotic Process I-kappaB Kinase/NF-kappaB Signaling Programmed Cell Death Cell Death Death Positive Regulation Of Immune System Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Immune System Process Regulation Of Cell Death Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Immune System Process Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Innate Immune Response Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance	Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Cellular Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Cellular Macromolecule Catabolic Process Positive Regulation Of Protein Catabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Proteolysis Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Innate Immune Response Regulation Of Protein Catabolic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Protein Modification Process Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Negative Regulation Of Signaling Toll-like Receptor 4 Signaling Pathway Protein K63-linked Ubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cellular Protein Metabolic Process Proteasomal Protein Catabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Protein Metabolic Process Negative Regulation Of Type I Interferon Production Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Immune Response-regulating Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Intracellular Transport Cellular Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Transforming Growth Factor Beta Receptor Signaling Pathway Protein Metabolic Process Intracellular Protein Transport Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Innate Immune Response Cellular Response To Stimulus
Tagcloud ?		125a 7e 99b arthritis clusters conversion depletion exacerbated il15 immunomodulatory inappropriate involve let micrornas mirna mirnas monocyte monocytes monocytic osteoclast p65 promoters proper rheumatoid shutting upregulates upregulating upregulation whereby
Tagcloud (Difference) ?		125a 7e 99b arthritis clusters conversion depletion exacerbated il15 immunomodulatory inappropriate involve let micrornas mirna mirnas monocyte monocytes monocytic osteoclast p65 promoters proper rheumatoid shutting upregulates upregulating upregulation whereby
Tagcloud (Intersection) ?