TNFAIP3 and RLIM

Number of citations of the paper that reports this interaction (PMID 23105109)
4

Data Source:
BioGRID (two hybrid)

		TNFAIP3	RLIM
Gene Name		tumor necrosis factor, alpha-induced protein 3	ring finger protein, LIM domain interacting
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Centrosome Cytosol Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Transcriptional Repressor Complex
	Molecular Function	Protease Binding DNA Binding Ubiquitin-protein Transferase Activity Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Ligase Activity Kinase Binding Ubiquitin Binding Protein Self-association	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity
	Biological Process	B-1 B Cell Homeostasis Response To Molecule Of Bacterial Origin Regulation Of Germinal Center Formation Negative Regulation Of Chronic Inflammatory Response Proteolysis Apoptotic Process Inflammatory Response Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Response To Muramyl Dipeptide Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Protein K11-linked Deubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Bone Resorption Negative Regulation Of Innate Immune Response Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Defense Response To Virus By Host Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Activation Protein Oligomerization Regulation Of Vascular Wound Healing Cellular Response To Hydrogen Peroxide Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Protein K48-linked Deubiquitination Cellular Response To Lipopolysaccharide Tolerance Induction To Lipopolysaccharide Establishment Of Protein Localization To Vacuole Negative Regulation Of Osteoclast Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of CD40 Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Random Inactivation Of X Chromosome
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Innate Immune System
Drugs
Diseases
GWAS		Cardiac Troponin-T levels ( 23247143) Celiac disease ( 20190752) Inflammatory bowel disease ( 23128233) Psoriasis ( 20953190 19169254) Rheumatoid arthritis ( 20453841 20453842 17982456) Systemic lupus erythematosus ( 23273568 19165918 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-Protein Interactions		38 interactors: ARRDC3 CCDC50 CHUK GIT2 IKBKB IKBKG LAPTM5 OCLN RBCK1 RIPK1 RLIM RNF11 RNF14 RNF5 TAX1BP1 TICAM1 TNF TNIP1 TNIP2 TNIP3 TRAF1 TRAF2 TRAF6 TRIM2 TRIM23 TRIM3 TRIM5 TRIM8 UBC UBE2D1 UBE2N YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZFAND5	27 interactors: ESR1 ISL1 LDB1 LDB2 LHX1 LHX2 LHX3 LIMK1 LMO2 LNX2 PDLIM1 REXO1 RPS14 SIN3A SMURF2 SNX17 SS18L1 STAT6 STMN1 TERF1 TNFAIP3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2
Entrez ID		7128	51132
HPRD ID		01857	02304
Ensembl ID		ENSG00000118503	ENSG00000131263
Uniprot IDs		P21580	Q9NVW2
PDB IDs		2EQE 2EQF 2EQG 2VFJ 3DKB 3OJ3 3OJ4 3VUW 3VUX 3VUY 3ZJD 3ZJE 3ZJF 3ZJG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Innate Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Regulation Of Signaling Regulation Of Immune Response Protein Ubiquitination Protein Modification By Small Protein Conjugation Defense Response Apoptotic Process I-kappaB Kinase/NF-kappaB Signaling Programmed Cell Death Cell Death Death Positive Regulation Of Immune System Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Immune System Process Regulation Of Cell Death Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Immune System Process Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Innate Immune Response Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance	Protein K48-linked Ubiquitination Protein Polyubiquitination Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Activation Of Innate Immune Response Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Innate Immune Response RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Protein K11-linked Ubiquitination Negative Regulation Of RNA Biosynthetic Process Cellular Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Stimulus Positive Regulation Of Immune Response Gene Expression Regulation Of Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Regulation Of Immune System Process Regulation Of Innate Immune Response System Development Mitotic Spindle Assembly Checkpoint
Tagcloud ?		125a 7e 99b arthritis clusters conversion depletion exacerbated il15 immunomodulatory inappropriate involve let micrornas mirna mirnas monocyte monocytes monocytic osteoclast p65 promoters proper rheumatoid shutting upregulates upregulating upregulation whereby	activators acts clim coactivator deacetylase embryonic encoded enlarge exerts hdac homeodomain inactivation inducer interacts interfering p53 physically playing prevents recruiting repressed repression repressor s1 s4 sin3a sp1 tried
Tagcloud (Difference) ?		125a 7e 99b arthritis clusters conversion depletion exacerbated il15 immunomodulatory inappropriate involve let micrornas mirna mirnas monocyte monocytes monocytic osteoclast p65 promoters proper rheumatoid shutting upregulates upregulating upregulation whereby	activators acts clim coactivator deacetylase embryonic encoded enlarge exerts hdac homeodomain inactivation inducer interacts interfering p53 physically playing prevents recruiting repressed repression repressor s1 s4 sin3a sp1 tried
Tagcloud (Intersection) ?