TNFAIP3 and RAD23A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TNFAIP3	RAD23A
Description		TNF alpha induced protein 3	RAD23 nucleotide excision repair protein A
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GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Cytosol Extracellular Exosome	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Protein-containing Complex
	Molecular Function	Protease Binding DNA Binding Catalytic Activity Ubiquitin-protein Transferase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Transferase Activity Hydrolase Activity Enzyme Binding Kinase Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding K63-linked Deubiquitinase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding	Damaged DNA Binding Single-stranded DNA Binding Protein Binding Kinase Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Proteasome Binding Ubiquitin-specific Protease Binding
	Biological Process	B-1 B Cell Homeostasis Response To Molecule Of Bacterial Origin Immune System Process Regulation Of Germinal Center Formation Negative Regulation Of Chronic Inflammatory Response Proteolysis Apoptotic Process Inflammatory Response Cytoskeleton Organization Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cell Migration Protein Deubiquitination Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Ubiquitination Response To Muramyl Dipeptide Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Protein K11-linked Deubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Catabolic Process Negative Regulation Of Bone Resorption Negative Regulation Of Innate Immune Response Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Defense Response To Virus By Host Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Activation Regulation Of Vascular Wound Healing Cellular Response To Hydrogen Peroxide Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Protein K48-linked Deubiquitination Cellular Response To Lipopolysaccharide Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Tolerance Induction To Lipopolysaccharide Establishment Of Protein Localization To Vacuole Negative Regulation Of Osteoclast Proliferation Cellular Response To Oxygen-containing Compound Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of CD40 Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	DNA Repair Nucleotide-excision Repair DNA Damage Response Protein Destabilization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Positive Regulation Of Cell Cycle
Pathways		NOD1/2 Signaling Pathway TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ovarian tumor domain proteases Negative regulators of DDX58/IFIH1 signaling	Josephin domain DUBs DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Autoimmune traits (pleiotropy) ( 30572963) Cardiac Troponin-T levels ( 23247143) Celiac disease ( 20190752 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cutaneous psoriasis ( 26626624) Hodgkin's lymphoma ( 30194254) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Malaria ( 31844061) Multiple sclerosis ( 24076602) Phosphatidylcholine-ether levels ( 31551469) Primary biliary cholangitis ( 26394269) Psoriasis ( 25574825 19169254 25903422 20953190 23143594) Psoriasis vulgaris ( 26626624) Rheumatoid arthritis ( 24449572 24390342 23143596 20453841 32723749 30423114 17982456) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Sjögren's syndrome ( 24097066 24097067) Systemic lupus erythematosus ( 19165918 28714469 27399966 26663301 26502338 23273568 19838195 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 28314753) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Tonsillectomy ( 28928442 27182965) Type 1 diabetes ( 34127860)	Clozapine-induced agranulocytosis ( 25187353)
Interacting Genes		61 interacting genes: ANKRD13D ARRDC3 ATP2A2 CALCOCO2 CCDC50 CCDC90B CHUK CLEC4G COL1A1 DRC4 FABP4 GIT2 GNAI2 IKBKB IKBKG LAPTM5 LNX1 MAP3K5 OCLN PCBP1 PFKL PIBF1 PSMA7 RAD23A RBCK1 RIPK1 RLIM RNF11 RNF14 RNF168 RNF216 RNF5 RPS15 RPS20 SNAI1 TAX1BP1 TICAM1 TIFA TNIP1 TNIP2 TRAF1 TRAF2 TRAF6 TRIM2 TRIM23 TRIM3 TRIM5 TRIM8 UBC UBE2D1 UBE2N UBQLN1 UBXN6 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZFAND5 ZNF251	79 interacting genes: A2M ADRM1 ANKRD40 ATXN3 ATXN7 CCNA2 CDC37 CEBPA CHEK1 CNTROB CREBBP DAZAP2 DBI ECSIT EP300 EWSR1 FILIP1 GTF2H1 H4C1 HSPB1 IFIT3 IFIT5 KRTAP12-2 LOXL4 MAP3K1 MAST1 MDM2 MINDY3 MKRN1 MPG NEDD8 NGLY1 NUTM2F OGT PDE6D PHAX PI4K2A PRKN PSEN1 PSMC5 PSMD4 RABGEF1 REL RNF115 RNF32 RNF41 RPN1 RPS27A SH3RF1 SMURF1 SQSTM1 TNFAIP3 TRAF2 TRAF3 TRAF5 TRAF6 TRIM39 TRIM50 TRIM54 TRIM55 TRIM8 TRIP6 UBA52 UBB UBC UBE3A UBE4B UBL7 UBQLN4 UBXN1 UIMC1 USP25 VAV2 WWP2 XPC ZBTB26 ZBTB44 ZBTB8A ZFAND6
Entrez ID		7128	5886
HPRD ID		01857	07191
Ensembl ID		ENSG00000118503	ENSG00000179262
Uniprot IDs		P21580	A8K1J3 P54725
PDB IDs		2EQE 2EQF 2EQG 2VFJ 3DKB 3OJ3 3OJ4 3VUW 3VUX 3VUY 3ZJD 3ZJE 3ZJF 3ZJG 5LRX 5V3B 5V3P	1DV0 1F4I 1IFY 1OQY 1P98 1P9D 1QZE 1TP4 2WYQ 5XBO 6W2G 6W2H 6W2I 6XQI 6XQJ 7TGP 8Q06
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Regulation Of Canonical NF-kappaB Signal Transduction Post-translational Protein Modification Ubiquitin Protein Ligase Activity Regulation Of Intracellular Signal Transduction Ubiquitin-protein Transferase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Modification-dependent Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteolysis Involved In Protein Catabolic Process Regulation Of Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Ubiquitin-dependent Protein Catabolic Process Cytoplasm Positive Regulation Of Intracellular Signal Transduction Macromolecule Catabolic Process Regulation Of Immune Response Protein Modification Process Cytosol Activation Of Innate Immune Response Activation Of Immune Response Protein K63-linked Ubiquitination Immune Response-activating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Signaling Adaptor Activity Protein Metabolic Process Positive Regulation Of Signal Transduction Identical Protein Binding Catabolic Process Innate Immune Response-activating Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Immune Response Positive Regulation Of Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Innate Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Defense Response Protein Sequestering Activity Positive Regulation Of Innate Immune Response Positive Regulation Of Immune System Process Proteasomal Protein Catabolic Process Cell Surface Toll-like Receptor Signaling Pathway	Post-translational Protein Modification Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification Process Protein Modification By Small Protein Conjugation Cytosol Protein Polyubiquitination Protein Autoubiquitination Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Proteasomal Protein Catabolic Process Proteolysis Macromolecule Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Zinc Ion Binding Regulation Of Protein Metabolic Process Protein K63-linked Ubiquitination Ubiquitin-protein Transferase Activity Cytoplasm Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin-dependent Protein Catabolic Process Protein Tag Activity Macromolecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Protein Catabolic Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Protein K48-linked Deubiquitination CD40 Receptor Complex Transferase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Catabolic Process Canonical NF-kappaB Signal Transduction Positive Regulation Of Proteolysis Ubiquitin Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Immune Response-regulating Cell Surface Receptor Signaling Pathway Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Protein Binding Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Signaling
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