SYT4 and SGTA

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
HPRD (two hybrid)

		SYT4	SGTA
Description		synaptotagmin 4	small glutamine rich tetratricopeptide repeat co-chaperone alpha
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GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Axon Dendrite Synaptic Vesicle Membrane Dense Core Granule Cytoplasmic Vesicle Vesicle Dense Core Granule Membrane Somatodendritic Compartment Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Exocytic Vesicle Astrocyte Projection Glutamatergic Synapse Neuronal Dense Core Vesicle Neuronal Dense Core Vesicle Membrane Microvesicle	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane TRC Complex
	Molecular Function	SNARE Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Metal Ion Binding Calcium Ion Sensor Activity	Protein Binding Identical Protein Binding Molecular Adaptor Activity BAT3 Complex Binding
	Biological Process	Vesicle Fusion Neurotransmitter Secretion Memory Positive Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Endocytosis Cell Differentiation Regulation Of Vesicle Fusion Negative Regulation Of Catecholamine Secretion Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Short-term Neuronal Synaptic Plasticity Negative Regulation Of Protein Secretion Calcium-dependent Activation Of Synaptic Vesicle Fusion Dense Core Granule Cytoskeletal Transport Regulation Of Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Regulation Of Postsynaptic Dense Core Vesicle Exocytosis Negative Regulation Of Secretion By Cell Positive Regulation Of Dendrite Extension Positive Regulation Of Dense Core Granule Exocytosis Negative Regulation Of Retrograde Trans-synaptic Signaling By Neuropeptide Negative Regulation Of Synaptic Vesicle Exocytosis	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane ERAD Pathway Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of ERAD Pathway Positive Regulation Of ERAD Pathway Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways			Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Body mass index ( 25673413 28892062) Carotid intima media thickness x smoking interaction ( 32117412) Ceramide levels (C24:0) ( 32489964) Coffee consumption ( 31046077) Metabolite levels ( 23823483) Parkinson's disease ( 28892059 21738487) Physical activity (moderate intensity activity duration) ( 30531941) Physical activity (overall physical activity time) ( 30531941) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Pulse pressure ( 27841878) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 27841878) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)	Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		13 interacting genes: BRWD1 NBR1 NDUFA12 NRXN1 SGTA SGTB STX1A STX2 STX3 STX4 SYNCRIP SYT1 TFAP2B	182 interacting genes: ADAM21 ADIPOQ ADRM1 AGR2 AGR3 AOC3 BAG6 BCL2L12 BTC C1QA C1QL4 C1QTNF1 C1QTNF5 C1QTNF6 C3orf52 C5orf46 CD79B CD99 CD99L2 CDH15 CDSN CHRNG COL1A2 COL8A2 CREB3L3 CSF1 CST1 CTAG1A CTAG1B CTSL CXCL8 CYB5R1 DEFA6 DEFB131A DKK3 DMKN EDA2R EDAR EFEMP1 EFEMP2 ERP27 ERP29 ETNK1 EVA1B F11R FERD3L FGF21 FIP1L1 FKBP7 FSTL1 FXYD2 FXYD7 FZD7 GABARAPL2 GAL GALP GHR GIP GPX7 GRN GUCA2A GYPA HSP90AA1 HSP90AB1 HSPA13 HSPA4 IER3 IGFBP6 IGL IGLC1 IL6ST IRF3 IRF5 ITPRIPL1 KASH5 KCNA1 KCNA10 KCNE5 KLHL20 KRT6A KTN1 LAIR2 LAT LCN2 LDLRAD4 LSMEM2 MRAP2 MS4A3 MSMB MSTN MYDGF MYOC NAXD NME3 NPVF NR3C1 NRSN2 NXF1 PAGE3 PBXIP1 PCDHA4 PCDHGA4 PFN2 PGLYRP2 PGR PIAS1 PLAAT4 PMEPA1 PODXL PPIB PPIC PPP1R3C PRAP1 PRB4 PRRG2 PSORS1C2 PTN PYY RCN1 RNASE10 RNF144A RNF144B RNF170 RPN1 SDC4 SDF2L1 SERPINE1 SERPINI2 SGCA SGTB SHISA4 SHISA5 SLPI SMAGP SMIM14 SMIM5 SOD3 SPINK9 SPN SPP1 SPPL2A SRGN SRL STMP1 SUOX SYT11 SYT4 TFF3 TFRC TGFA TIAM1 TMEM154 TMEM174 TMEM230 TMEM31 TMEM98 TMPO TMPRSS11D TMUB2 TNFRSF10C TNFRSF13B TNFRSF19 TNFRSF1A TNFRSF21 TNFSF12 TRIM5 TWSG1 TXNDC12 UBL4A UBQLN2 UPK3A USP14 USP5 USP9X VIP WBP1L WFDC12 WFDC13 WFDC5 ZBTB8B ZG16 ZG16B
Entrez ID		6860	6449
HPRD ID		02519	04568
Ensembl ID		ENSG00000132872	ENSG00000104969
Uniprot IDs		Q9H2B2	O43765
PDB IDs		1UGK	2VYI 4CPG 4GOD 4GOE 4GOF
Enriched GO Terms of Interacting Partners?		SNARE Binding Vesicle Docking Organelle Localization By Membrane Tethering Membrane Docking Vesicle Fusion Neurotransmitter Transport Organelle Membrane Fusion SNAP Receptor Activity SNARE Complex Organelle Fusion Positive Regulation Of Synaptic Transmission Membrane Fusion Secretion By Cell Exocytosis Calcium-dependent Protein Binding Organelle Localization TRC Complex Secretion Vesicle Organization Membrane Organization Positive Regulation Of Regulated Secretory Pathway Cornified Envelope Assembly Membrane Assembly Establishment Of Protein Localization Positive Regulation Of Protein Localization To Plasma Membrane Modulation Of Chemical Synaptic Transmission Positive Regulation Of Protein Localization To Cell Periphery Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Endomembrane System Positive Regulation Of Catecholamine Secretion SNARE Complex Assembly Positive Regulation Of Exocytosis Positive Regulation Of Protein Localization To Membrane Glutamatergic Synapse Vesicle-mediated Transport In Synapse Cellular Localization Specific Granule Schaffer Collateral - CA1 Synapse Secretory Granule Positive Regulation Of Calcium Ion-dependent Exocytosis Vacuole Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Surface Neuron Projection Positive Regulation Of Neurotransmitter Secretion Regulation Of Regulated Secretory Pathway Membrane Presynaptic Membrane Protein Heterooligomerization Regulation Of Protein Localization To Cell Periphery	Extracellular Region Extracellular Space Protein Binding Endoplasmic Reticulum Lumen Response To Bacterium Defense Response To Bacterium Collagen Trimer Response To Stress Membrane Response To Other Organism Antimicrobial Humoral Response Endoplasmic Reticulum Immune System Process Regulation Of Immune System Process Humoral Immune Response Peptidase Inhibitor Activity Negative Regulation Of Cell Activation Positive Regulation Of Leukocyte Migration Serine-type Endopeptidase Inhibitor Activity Defense Response Extracellular Exosome Defense Response To Symbiont Negative Regulation Of Proteasomal Protein Catabolic Process Antibacterial Humoral Response Plasma Membrane Immune Response Defense Response To Other Organism Negative Regulation Of Leukocyte Activation Identical Protein Binding Negative Regulation Of Cell Adhesion Positive Regulation Of MAPK Cascade Response To External Biotic Stimulus Tumor Necrosis Factor Receptor Activity Negative Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Immune System Process Hormone Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Glucocorticoid Metabolic Process Growth Factor Activity Fibronectin Binding Macrophage Apoptotic Process BAT3 Complex Regulation Of Cell Adhesion Protein Folding Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Lymphocyte Proliferation Epidermal Growth Factor Receptor Binding Negative Regulation Of Mononuclear Cell Proliferation
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