SYT4 and NDUFA12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SYT4	NDUFA12
Description		synaptotagmin 4	NADH:ubiquinone oxidoreductase subunit A12
Image
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Axon Dendrite Synaptic Vesicle Membrane Dense Core Granule Cytoplasmic Vesicle Vesicle Dense Core Granule Membrane Somatodendritic Compartment Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Exocytic Vesicle Astrocyte Projection Glutamatergic Synapse Neuronal Dense Core Vesicle Neuronal Dense Core Vesicle Membrane Microvesicle	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I
	Molecular Function	SNARE Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Metal Ion Binding Calcium Ion Sensor Activity	Protein Binding NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Vesicle Fusion Neurotransmitter Secretion Memory Positive Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Endocytosis Cell Differentiation Regulation Of Vesicle Fusion Negative Regulation Of Catecholamine Secretion Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Short-term Neuronal Synaptic Plasticity Negative Regulation Of Protein Secretion Calcium-dependent Activation Of Synaptic Vesicle Fusion Dense Core Granule Cytoskeletal Transport Regulation Of Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Regulation Of Postsynaptic Dense Core Vesicle Exocytosis Negative Regulation Of Secretion By Cell Positive Regulation Of Dendrite Extension Positive Regulation Of Dense Core Granule Exocytosis Negative Regulation Of Retrograde Trans-synaptic Signaling By Neuropeptide Negative Regulation Of Synaptic Vesicle Exocytosis	Aerobic Respiration Mitochondrial ATP Synthesis Coupled Electron Transport Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport
Pathways			Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases
GWAS		Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Body mass index ( 25673413 28892062) Carotid intima media thickness x smoking interaction ( 32117412) Ceramide levels (C24:0) ( 32489964) Coffee consumption ( 31046077) Metabolite levels ( 23823483) Parkinson's disease ( 28892059 21738487) Physical activity (moderate intensity activity duration) ( 30531941) Physical activity (overall physical activity time) ( 30531941) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Pulse pressure ( 27841878) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 27841878) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)	Brain morphology (MOSTest) ( 32665545) Chromosomal aberration frequency (chromosome type) ( 31586183) Coronary artery disease ( 29212778 32469254) Heel bone mineral density x serum urate levels interaction ( 34046847) Myocardial infarction ( 33532862)
Interacting Genes		13 interacting genes: BRWD1 NBR1 NDUFA12 NRXN1 SGTA SGTB STX1A STX2 STX3 STX4 SYNCRIP SYT1 TFAP2B	4 interacting genes: MYO15B SYT4 TMED8 ZNF768
Entrez ID		6860	55967
HPRD ID		02519	16781
Ensembl ID		ENSG00000132872	ENSG00000184752
Uniprot IDs		Q9H2B2	Q9UI09
PDB IDs		1UGK	5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		SNARE Binding Vesicle Docking Organelle Localization By Membrane Tethering Membrane Docking Vesicle Fusion Neurotransmitter Transport Organelle Membrane Fusion SNAP Receptor Activity SNARE Complex Organelle Fusion Positive Regulation Of Synaptic Transmission Membrane Fusion Secretion By Cell Exocytosis Calcium-dependent Protein Binding Organelle Localization TRC Complex Secretion Vesicle Organization Membrane Organization Positive Regulation Of Regulated Secretory Pathway Cornified Envelope Assembly Membrane Assembly Establishment Of Protein Localization Positive Regulation Of Protein Localization To Plasma Membrane Modulation Of Chemical Synaptic Transmission Positive Regulation Of Protein Localization To Cell Periphery Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Endomembrane System Positive Regulation Of Catecholamine Secretion SNARE Complex Assembly Positive Regulation Of Exocytosis Positive Regulation Of Protein Localization To Membrane Glutamatergic Synapse Vesicle-mediated Transport In Synapse Cellular Localization Specific Granule Schaffer Collateral - CA1 Synapse Secretory Granule Positive Regulation Of Calcium Ion-dependent Exocytosis Vacuole Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Surface Neuron Projection Positive Regulation Of Neurotransmitter Secretion Regulation Of Regulated Secretory Pathway Membrane Presynaptic Membrane Protein Heterooligomerization Regulation Of Protein Localization To Cell Periphery	Positive Regulation Of Dense Core Granule Exocytosis Negative Regulation Of Retrograde Trans-synaptic Signaling By Neuropeptide Regulation Of Postsynaptic Dense Core Vesicle Exocytosis Negative Regulation Of Short-term Neuronal Synaptic Plasticity Dense Core Granule Membrane Regulation Of Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Regulation Of Dense Core Granule Exocytosis Neuronal Dense Core Vesicle Membrane Negative Regulation Of Synaptic Vesicle Exocytosis Negative Regulation Of Calcium Ion-dependent Exocytosis Microvesicle Dense Core Granule Cytoskeletal Transport Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Calcium-dependent Activation Of Synaptic Vesicle Fusion Somatodendritic Compartment Secretory Granule Localization Negative Regulation Of Catecholamine Secretion Dense Core Granule Positive Regulation Of Calcium Ion-dependent Exocytosis Neuronal Dense Core Vesicle Positive Regulation Of Dendrite Extension Calcium Ion Sensor Activity Astrocyte Projection Regulation Of Glutamate Secretion Positive Regulation Of Glutamate Secretion Positive Regulation Of Amino Acid Transport Regulation Of Short-term Neuronal Synaptic Plasticity Positive Regulation Of Vesicle Fusion Regulation Of Dopamine Secretion Exocytic Vesicle Regulation Of Vesicle Fusion Regulation Of Catecholamine Secretion Regulation Of Calcium Ion-dependent Exocytosis Neurotransmitter Secretion Negative Regulation Of Exocytosis Positive Regulation Of Regulated Secretory Pathway Calcium-dependent Phospholipid Binding Regulation Of Synaptic Vesicle Exocytosis
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