SYT4 and STX4

Number of citations of the paper that reports this interaction (PMID 10397765)
9

Data Source:
HPRD (in vitro)

		SYT4	STX4
Gene Name		synaptotagmin IV	syntaxin 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane Dense Core Granule Neuron Projection Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Extracellular Space Intracellular Endosome Vacuole Trans-Golgi Network Cytosol Plasma Membrane Synaptic Vesicle Cell Surface Membrane Integral Component Of Membrane Basolateral Plasma Membrane Lamellipodium SNARE Complex Myelin Sheath Adaxonal Region Somatodendritic Compartment Specific Granule Dendritic Spine Lateral Loop Synapse Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	SNARE Binding Phosphatidylserine Binding Transporter Activity Calcium Ion Binding Clathrin Binding	SNARE Binding SNAP Receptor Activity Protein Binding Sphingomyelin Phosphodiesterase Activator Activity
	Biological Process	Exocytosis Neurotransmitter Secretion Negative Regulation Of Vesicle Fusion Negative Regulation Of Calcium Ion-dependent Exocytosis	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Blood Coagulation Positive Regulation Of Cell Proliferation Regulation Of Exocytosis Platelet Activation Positive Regulation Of Cell Migration Synaptic Vesicle Fusion To Presynaptic Membrane Response To Hydroperoxide SNARE Complex Assembly Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Catalytic Activity Positive Regulation Of Eosinophil Degranulation Positive Regulation Of Cell Adhesion Vesicle Docking Organelle Fusion Positive Regulation Of Chemotaxis Positive Regulation Of Immunoglobulin Secretion Long-term Synaptic Potentiation Membrane Organization Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Surface
Pathways			Response to elevated platelet cytosolic Ca2+ Translocation of GLUT4 to the plasma membrane Disinhibition of SNARE formation Platelet activation, signaling and aggregation trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS		Parkinson's disease ( 21738487)
Protein-Protein Interactions		10 interactors: NBR1 NRXN1 SGTA STX1A STX2 STX3 STX4 SYNCRIP SYT1 TFAP2B	48 interactors: ACTB BET1 CYBRD1 DLG1 GIMAP5 GOSR2 ITSN2 LLGL1 NAPA NAPB NSF PSMA3 RAB11A RAB4A RAB5A SCRIB SEC22A SEPT5 SNAP23 SNAP25 SNAP29 SNAP47 STX12 STX16 STX3 STX5 STX6 STX7 STX8 STXBP3 STXBP4 STXBP5 STXBP6 SYT1 SYT4 SYT7 TXLNA TXLNB TXLNG VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VAMP7 VAMP8 VAPB VTI1B
Entrez ID		6860	6810
HPRD ID		02519	01722
Ensembl ID		ENSG00000132872	ENSG00000103496
Uniprot IDs		B4DEU3 Q9H2B2	A8MXY0 B7Z425 Q12846
PDB IDs		1UGK
Enriched GO Terms of Interacting Partners?		Neurotransmitter Secretion Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Neurotransmitter Levels Synaptic Vesicle Exocytosis Neurotransmitter Transport Vesicle Localization Vesicle Docking Membrane Docking Positive Regulation Of Synaptic Transmission Synaptic Vesicle Transport Vesicle Fusion Organelle Localization Establishment Of Vesicle Localization Secretion By Cell Organelle Fusion Synaptic Transmission Secretion Regulation Of Synaptic Transmission Establishment Of Organelle Localization Exocytosis Positive Regulation Of Protein Localization To Plasma Membrane Membrane Fusion Cell-cell Signaling Regulation Of Insulin Secretion Vesicle Organization Regulation Of Cellular Localization Regulation Of Protein Localization To Plasma Membrane Regulation Of Peptide Hormone Secretion Positive Regulation Of Exocytosis Regulation Of Hormone Secretion Regulation Of Secretion Positive Regulation Of Protein Localization To Cell Surface Regulation Of Protein Localization Membrane Organization Regulation Of Protein Secretion Regulation Of Exocytosis Regulation Of Protein Localization To Cell Surface Protein Complex Assembly Response To Hydroperoxide Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Glutamate Secretion Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Behavior Establishment Of Localization In Cell Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Protein Transport Cellular Protein Localization Regulation Of Establishment Of Protein Localization Regulation Of Regulated Secretory Pathway	Vesicle Fusion Membrane Fusion Organelle Fusion Vesicle-mediated Transport Membrane Organization Vesicle Organization Establishment Of Localization In Cell Cellular Localization Exocytosis Secretion By Cell Secretion Transport Golgi Vesicle Transport Protein Transport Establishment Of Protein Localization Protein Localization Intracellular Transport Neurotransmitter Secretion Regulation Of Exocytosis Regulation Of Cellular Localization Vesicle Docking Regulation Of Vesicle-mediated Transport Post-Golgi Vesicle-mediated Transport Membrane Docking Regulation Of Neurotransmitter Levels Intracellular Protein Transport Neurotransmitter Transport Synaptic Vesicle Exocytosis Vesicle Fusion With Golgi Apparatus Synaptic Vesicle Transport Cellular Protein Localization Regulation Of Secretion Establishment Of Vesicle Localization Vesicle Localization Cell-cell Signaling Organelle Organization Endomembrane System Organization Cytoplasmic Transport SNARE Complex Assembly Endosomal Transport Regulation Of Protein Localization To Plasma Membrane Synaptic Vesicle Fusion To Presynaptic Membrane Organelle Localization Establishment Of Organelle Localization Synaptic Transmission Golgi To Plasma Membrane Transport Regulation Of Protein Localization ER To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Protein Transport Positive Regulation Of Exocytosis
Tagcloud ?			address ageing armx3 b2mg consequence dep1 ebp50 effectors fact issue lancl1 maintaining modulators note ntal organismal pld3 preferentially recognize screened senescence senescent sorting straightforward triggering utilized vamp3 view vps26a
Tagcloud (Difference) ?			address ageing armx3 b2mg consequence dep1 ebp50 effectors fact issue lancl1 maintaining modulators note ntal organismal pld3 preferentially recognize screened senescence senescent sorting straightforward triggering utilized vamp3 view vps26a
Tagcloud (Intersection) ?