SGTA and EDA2R

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SGTA	EDA2R
Description		small glutamine rich tetratricopeptide repeat co-chaperone alpha	ectodysplasin A2 receptor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane TRC Complex	Plasma Membrane Membrane
	Molecular Function	Protein Binding Identical Protein Binding Molecular Adaptor Activity BAT3 Complex Binding	Transmembrane Signaling Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Signaling Receptor Activity
	Biological Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane ERAD Pathway Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of ERAD Pathway Positive Regulation Of ERAD Pathway Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Epidermis Development Ectodermal Cell Differentiation Cytokine-mediated Signaling Pathway Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JNK Cascade Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Balding ( 26926045) Male-pattern baldness ( 22032556 27182965 28196072)
Interacting Genes		182 interacting genes: ADAM21 ADIPOQ ADRM1 AGR2 AGR3 AOC3 BAG6 BCL2L12 BTC C1QA C1QL4 C1QTNF1 C1QTNF5 C1QTNF6 C3orf52 C5orf46 CD79B CD99 CD99L2 CDH15 CDSN CHRNG COL1A2 COL8A2 CREB3L3 CSF1 CST1 CTAG1A CTAG1B CTSL CXCL8 CYB5R1 DEFA6 DEFB131A DKK3 DMKN EDA2R EDAR EFEMP1 EFEMP2 ERP27 ERP29 ETNK1 EVA1B F11R FERD3L FGF21 FIP1L1 FKBP7 FSTL1 FXYD2 FXYD7 FZD7 GABARAPL2 GAL GALP GHR GIP GPX7 GRN GUCA2A GYPA HSP90AA1 HSP90AB1 HSPA13 HSPA4 IER3 IGFBP6 IGL IGLC1 IL6ST IRF3 IRF5 ITPRIPL1 KASH5 KCNA1 KCNA10 KCNE5 KLHL20 KRT6A KTN1 LAIR2 LAT LCN2 LDLRAD4 LSMEM2 MRAP2 MS4A3 MSMB MSTN MYDGF MYOC NAXD NME3 NPVF NR3C1 NRSN2 NXF1 PAGE3 PBXIP1 PCDHA4 PCDHGA4 PFN2 PGLYRP2 PGR PIAS1 PLAAT4 PMEPA1 PODXL PPIB PPIC PPP1R3C PRAP1 PRB4 PRRG2 PSORS1C2 PTN PYY RCN1 RNASE10 RNF144A RNF144B RNF170 RPN1 SDC4 SDF2L1 SERPINE1 SERPINI2 SGCA SGTB SHISA4 SHISA5 SLPI SMAGP SMIM14 SMIM5 SOD3 SPINK9 SPN SPP1 SPPL2A SRGN SRL STMP1 SUOX SYT11 SYT4 TFF3 TFRC TGFA TIAM1 TMEM154 TMEM174 TMEM230 TMEM31 TMEM98 TMPO TMPRSS11D TMUB2 TNFRSF10C TNFRSF13B TNFRSF19 TNFRSF1A TNFRSF21 TNFSF12 TRIM5 TWSG1 TXNDC12 UBL4A UBQLN2 UPK3A USP14 USP5 USP9X VIP WBP1L WFDC12 WFDC13 WFDC5 ZBTB8B ZG16 ZG16B	16 interacting genes: AGR3 ATP6V0C C1QB CASP8 CATSPERH CEBPE EDA FADD GIMAP5 JAGN1 NKG7 PLP1 SGTA STRIT1 TRAF3 TRAF6
Entrez ID		6449	60401
HPRD ID		04568	02230
Ensembl ID		ENSG00000104969	ENSG00000131080
Uniprot IDs		O43765	B2RBZ9 B4DQY6 Q9HAV5
PDB IDs		2VYI 4CPG 4GOD 4GOE 4GOF
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Protein Binding Endoplasmic Reticulum Lumen Response To Bacterium Defense Response To Bacterium Collagen Trimer Response To Stress Membrane Response To Other Organism Antimicrobial Humoral Response Endoplasmic Reticulum Immune System Process Regulation Of Immune System Process Humoral Immune Response Peptidase Inhibitor Activity Negative Regulation Of Cell Activation Positive Regulation Of Leukocyte Migration Serine-type Endopeptidase Inhibitor Activity Defense Response Extracellular Exosome Defense Response To Symbiont Negative Regulation Of Proteasomal Protein Catabolic Process Antibacterial Humoral Response Plasma Membrane Immune Response Defense Response To Other Organism Negative Regulation Of Leukocyte Activation Identical Protein Binding Negative Regulation Of Cell Adhesion Positive Regulation Of MAPK Cascade Response To External Biotic Stimulus Tumor Necrosis Factor Receptor Activity Negative Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Immune System Process Hormone Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Glucocorticoid Metabolic Process Growth Factor Activity Fibronectin Binding Macrophage Apoptotic Process BAT3 Complex Regulation Of Cell Adhesion Protein Folding Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Lymphocyte Proliferation Epidermal Growth Factor Receptor Binding Negative Regulation Of Mononuclear Cell Proliferation	Tumor Necrosis Factor Receptor Binding Death Receptor Binding Defense Response Death Effector Domain Binding Response To External Biotic Stimulus Ripoptosome CD95 Death-inducing Signaling Complex Regulation Of Canonical NF-kappaB Signal Transduction Myeloid Leukocyte Differentiation Death-inducing Signaling Complex Leukocyte Differentiation Regulation Of Proteolysis Positive Regulation Of Myeloid Leukocyte Differentiation TRAIL-activated Apoptotic Signaling Pathway CD40 Receptor Complex TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Defense Response Signaling Adaptor Activity MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Gene Expression Myeloid Cell Differentiation Positive Regulation Of Macrophage Differentiation Endosome Membrane Negative Regulation Of Necroptotic Process Positive Regulation Of Myeloid Cell Differentiation Cytoplasmic Side Of Plasma Membrane Immune System Process Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Programmed Necrotic Cell Death Response To Stress Regulation Of Myeloid Leukocyte Differentiation Mononuclear Cell Differentiation Tube Formation Regulation Of Macrophage Differentiation Innate Immune Response Granulocyte Differentiation Regulation Of Necroptotic Process Response To Other Organism Defense Response To Symbiont Regulation Of Programmed Necrotic Cell Death Cytokine-mediated Signaling Pathway Defense Response To Other Organism Immune Response Toll-like Receptor 4 Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Innate Immune Response Macrophage Differentiation Regulation Of Defense Response Positive Regulation Of Leukocyte Differentiation
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