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SGTA and CXCL8
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
SGTA
CXCL8
Description
small glutamine rich tetratricopeptide repeat co-chaperone alpha
C-X-C motif chemokine ligand 8
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
TRC Complex
Extracellular Region
Extracellular Space
Molecular Function
Protein Binding
Identical Protein Binding
Molecular Adaptor Activity
BAT3 Complex Binding
Cytokine Activity
Interleukin-8 Receptor Binding
Protein Binding
Chemokine Activity
Heparin Binding
CXCR Chemokine Receptor Binding
Biological Process
Post-translational Protein Targeting To Endoplasmic Reticulum Membrane
ERAD Pathway
Tail-anchored Membrane Protein Insertion Into ER Membrane
Negative Regulation Of ERAD Pathway
Positive Regulation Of ERAD Pathway
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Angiogenesis
Response To Molecule Of Bacterial Origin
Chemotaxis
Defense Response
Inflammatory Response
Immune Response
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Calcium-mediated Signaling
Regulation Of Cell Adhesion
Neutrophil Chemotaxis
Receptor Internalization
Killing Of Cells Of Another Organism
Response To Endoplasmic Reticulum Stress
Intracellular Signal Transduction
Neutrophil Activation
Cellular Response To Fibroblast Growth Factor Stimulus
Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Angiogenesis
Embryonic Digestive Tract Development
Induction Of Positive Chemotaxis
Negative Regulation Of Cell Adhesion Molecule Production
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Neutrophil Chemotaxis
Regulation Of Entry Of Bacterium Into Host Cell
Pathways
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Senescence-Associated Secretory Phenotype (SASP)
Peptide ligand-binding receptors
Chemokine receptors bind chemokines
ATF4 activates genes in response to endoplasmic reticulum stress
G alpha (i) signalling events
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Drugs
ABT-510
MDX-018
Rivanicline
Oleandrin
Diseases
GWAS
Femur bone mineral density x serum urate levels interaction (
34046847
)
Chronic kidney disease (
30226566
)
Coronary artery disease (
30402224
)
Hypertension (
30226566
)
Ischemic stroke (
29930801
)
Myocardial infarction (
30226566
)
Interacting Genes
182 interacting genes:
ADAM21
ADIPOQ
ADRM1
AGR2
AGR3
AOC3
BAG6
BCL2L12
BTC
C1QA
C1QL4
C1QTNF1
C1QTNF5
C1QTNF6
C3orf52
C5orf46
CD79B
CD99
CD99L2
CDH15
CDSN
CHRNG
COL1A2
COL8A2
CREB3L3
CSF1
CST1
CTAG1A
CTAG1B
CTSL
CXCL8
CYB5R1
DEFA6
DEFB131A
DKK3
DMKN
EDA2R
EDAR
EFEMP1
EFEMP2
ERP27
ERP29
ETNK1
EVA1B
F11R
FERD3L
FGF21
FIP1L1
FKBP7
FSTL1
FXYD2
FXYD7
FZD7
GABARAPL2
GAL
GALP
GHR
GIP
GPX7
GRN
GUCA2A
GYPA
HSP90AA1
HSP90AB1
HSPA13
HSPA4
IER3
IGFBP6
IGL
IGLC1
IL6ST
IRF3
IRF5
ITPRIPL1
KASH5
KCNA1
KCNA10
KCNE5
KLHL20
KRT6A
KTN1
LAIR2
LAT
LCN2
LDLRAD4
LSMEM2
MRAP2
MS4A3
MSMB
MSTN
MYDGF
MYOC
NAXD
NME3
NPVF
NR3C1
NRSN2
NXF1
PAGE3
PBXIP1
PCDHA4
PCDHGA4
PFN2
PGLYRP2
PGR
PIAS1
PLAAT4
PMEPA1
PODXL
PPIB
PPIC
PPP1R3C
PRAP1
PRB4
PRRG2
PSORS1C2
PTN
PYY
RCN1
RNASE10
RNF144A
RNF144B
RNF170
RPN1
SDC4
SDF2L1
SERPINE1
SERPINI2
SGCA
SGTB
SHISA4
SHISA5
SLPI
SMAGP
SMIM14
SMIM5
SOD3
SPINK9
SPN
SPP1
SPPL2A
SRGN
SRL
STMP1
SUOX
SYT11
SYT4
TFF3
TFRC
TGFA
TIAM1
TMEM154
TMEM174
TMEM230
TMEM31
TMEM98
TMPO
TMPRSS11D
TMUB2
TNFRSF10C
TNFRSF13B
TNFRSF19
TNFRSF1A
TNFRSF21
TNFSF12
TRIM5
TWSG1
TXNDC12
UBL4A
UBQLN2
UPK3A
USP14
USP5
USP9X
VIP
WBP1L
WFDC12
WFDC13
WFDC5
ZBTB8B
ZG16
ZG16B
23 interacting genes:
ACKR1
ARFGAP3
BAG6
CCL2
CCL4
CCL5
CCL8
CTSL
CXCR1
CXCR2
EP300
ERBB2
GNAI2
IL12A
MMP14
MMP9
PF4
POMGNT1
SDC1
SGTA
WASF1
ZFP36
ZNF598
Entrez ID
6449
3576
HPRD ID
04568
00909
Ensembl ID
ENSG00000104969
ENSG00000169429
Uniprot IDs
O43765
C9J4T6
P10145
PDB IDs
2VYI
4CPG
4GOD
4GOE
4GOF
1ICW
1IKL
1IKM
1IL8
1ILP
1ILQ
1QE6
1ROD
2IL8
3IL8
4XDX
5D14
5WDZ
6LFM
6LFO
6N2U
6WZM
6XMN
8IC0
8XWN
8XX6
Enriched GO Terms of Interacting Partners
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Extracellular Region
Extracellular Space
Protein Binding
Endoplasmic Reticulum Lumen
Response To Bacterium
Defense Response To Bacterium
Collagen Trimer
Response To Stress
Membrane
Response To Other Organism
Antimicrobial Humoral Response
Endoplasmic Reticulum
Immune System Process
Regulation Of Immune System Process
Humoral Immune Response
Peptidase Inhibitor Activity
Negative Regulation Of Cell Activation
Positive Regulation Of Leukocyte Migration
Serine-type Endopeptidase Inhibitor Activity
Defense Response
Extracellular Exosome
Defense Response To Symbiont
Negative Regulation Of Proteasomal Protein Catabolic Process
Antibacterial Humoral Response
Plasma Membrane
Immune Response
Defense Response To Other Organism
Negative Regulation Of Leukocyte Activation
Identical Protein Binding
Negative Regulation Of Cell Adhesion
Positive Regulation Of MAPK Cascade
Response To External Biotic Stimulus
Tumor Necrosis Factor Receptor Activity
Negative Regulation Of Proteolysis
Positive Regulation Of Intracellular Signal Transduction
Post-translational Protein Targeting To Endoplasmic Reticulum Membrane
Positive Regulation Of Immune System Process
Hormone Activity
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Glucocorticoid Metabolic Process
Growth Factor Activity
Fibronectin Binding
Macrophage Apoptotic Process
BAT3 Complex
Regulation Of Cell Adhesion
Protein Folding
Negative Regulation Of Cell-cell Adhesion
Negative Regulation Of Lymphocyte Proliferation
Epidermal Growth Factor Receptor Binding
Negative Regulation Of Mononuclear Cell Proliferation
Chemokine-mediated Signaling Pathway
Granulocyte Chemotaxis
Granulocyte Migration
Cell Surface Receptor Signaling Pathway
Myeloid Leukocyte Migration
Leukocyte Chemotaxis
Cytokine-mediated Signaling Pathway
Cell Migration
Chemokine Activity
Cell Chemotaxis
Locomotion
Eosinophil Chemotaxis
Leukocyte Migration
Eosinophil Migration
C-C Chemokine Binding
Cell Motility
Positive Regulation Of Leukocyte Migration
CCR Chemokine Receptor Binding
Signal Transduction
Chemotaxis
Positive Regulation Of Mononuclear Cell Migration
Inflammatory Response
Mononuclear Cell Migration
Cytokine Activity
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Migration
Regulation Of Leukocyte Migration
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Response To Stress
Immune System Process
Regulation Of Mononuclear Cell Migration
Dendritic Cell Chemotaxis
Interleukin-8-mediated Signaling Pathway
Interleukin-8 Receptor Activity
Regulation Of Immune System Process
Antimicrobial Humoral Response
Receptor-mediated Endocytosis
Host-mediated Perturbation Of Viral Process
Positive Regulation Of Immune System Process
Monocyte Chemotaxis
Defense Response
Dendritic Cell Migration
Regulation Of Lymphocyte Chemotaxis
Interleukin-8 Binding
Positive Regulation Of Macrophage Migration
Regulation Of Apoptotic Process
Positive Regulation Of Leukocyte Chemotaxis
Host-mediated Perturbation Of Viral Transcription
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