SGTA and SPPL2A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)
HPRD (two hybrid)

		SGTA	SPPL2A
Description		small glutamine rich tetratricopeptide repeat co-chaperone alpha	signal peptide peptidase like 2A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane TRC Complex	Lysosome Lysosomal Membrane Endosome Late Endosome Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Golgi-associated Vesicle Membrane Late Endosome Membrane Extracellular Exosome Lumenal Side Of Endoplasmic Reticulum Membrane Cytoplasmic Side Of Endoplasmic Reticulum Membrane Bounding Membrane Of Organelle
	Molecular Function	Protein Binding Identical Protein Binding Molecular Adaptor Activity BAT3 Complex Binding	Protein Binding Peptidase Activity Hydrolase Activity Aspartic Endopeptidase Activity, Intramembrane Cleaving Protein Homodimerization Activity
	Biological Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane ERAD Pathway Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of ERAD Pathway Positive Regulation Of ERAD Pathway Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Proteolysis Membrane Protein Ectodomain Proteolysis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Membrane Protein Intracellular Domain Proteolysis Membrane Protein Proteolysis Regulation Of Immune Response
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Regulation of TNFR1 signaling
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Alzheimer's disease (late onset) ( 24162737 30820047) Calcium levels ( 29403010) Chloride levels ( 29403010) Creatinine levels ( 29403010) Fibrinogen ( 23969696) Fibrinogen levels ( 26561523 28107422) General cognitive ability ( 29844566) Glomerular filtration rate ( 29403010) Lymphocyte count ( 32888494) Neutrophil count ( 27863252 32888494) Potassium levels ( 29403010) Red blood cell count ( 32888494) Refractive error ( 32231278) Sum basophil neutrophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		182 interacting genes: ADAM21 ADIPOQ ADRM1 AGR2 AGR3 AOC3 BAG6 BCL2L12 BTC C1QA C1QL4 C1QTNF1 C1QTNF5 C1QTNF6 C3orf52 C5orf46 CD79B CD99 CD99L2 CDH15 CDSN CHRNG COL1A2 COL8A2 CREB3L3 CSF1 CST1 CTAG1A CTAG1B CTSL CXCL8 CYB5R1 DEFA6 DEFB131A DKK3 DMKN EDA2R EDAR EFEMP1 EFEMP2 ERP27 ERP29 ETNK1 EVA1B F11R FERD3L FGF21 FIP1L1 FKBP7 FSTL1 FXYD2 FXYD7 FZD7 GABARAPL2 GAL GALP GHR GIP GPX7 GRN GUCA2A GYPA HSP90AA1 HSP90AB1 HSPA13 HSPA4 IER3 IGFBP6 IGL IGLC1 IL6ST IRF3 IRF5 ITPRIPL1 KASH5 KCNA1 KCNA10 KCNE5 KLHL20 KRT6A KTN1 LAIR2 LAT LCN2 LDLRAD4 LSMEM2 MRAP2 MS4A3 MSMB MSTN MYDGF MYOC NAXD NME3 NPVF NR3C1 NRSN2 NXF1 PAGE3 PBXIP1 PCDHA4 PCDHGA4 PFN2 PGLYRP2 PGR PIAS1 PLAAT4 PMEPA1 PODXL PPIB PPIC PPP1R3C PRAP1 PRB4 PRRG2 PSORS1C2 PTN PYY RCN1 RNASE10 RNF144A RNF144B RNF170 RPN1 SDC4 SDF2L1 SERPINE1 SERPINI2 SGCA SGTB SHISA4 SHISA5 SLPI SMAGP SMIM14 SMIM5 SOD3 SPINK9 SPN SPP1 SPPL2A SRGN SRL STMP1 SUOX SYT11 SYT4 TFF3 TFRC TGFA TIAM1 TMEM154 TMEM174 TMEM230 TMEM31 TMEM98 TMPO TMPRSS11D TMUB2 TNFRSF10C TNFRSF13B TNFRSF19 TNFRSF1A TNFRSF21 TNFSF12 TRIM5 TWSG1 TXNDC12 UBL4A UBQLN2 UPK3A USP14 USP5 USP9X VIP WBP1L WFDC12 WFDC13 WFDC5 ZBTB8B ZG16 ZG16B	2 interacting genes: NFKB1 SGTA
Entrez ID		6449	84888
HPRD ID		04568	09742
Ensembl ID		ENSG00000104969	ENSG00000138600
Uniprot IDs		O43765	A0A8V8TLZ2 Q8TCT8
PDB IDs		2VYI 4CPG 4GOD 4GOE 4GOF
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Protein Binding Endoplasmic Reticulum Lumen Response To Bacterium Defense Response To Bacterium Collagen Trimer Response To Stress Membrane Response To Other Organism Antimicrobial Humoral Response Endoplasmic Reticulum Immune System Process Regulation Of Immune System Process Humoral Immune Response Peptidase Inhibitor Activity Negative Regulation Of Cell Activation Positive Regulation Of Leukocyte Migration Serine-type Endopeptidase Inhibitor Activity Defense Response Extracellular Exosome Defense Response To Symbiont Negative Regulation Of Proteasomal Protein Catabolic Process Antibacterial Humoral Response Plasma Membrane Immune Response Defense Response To Other Organism Negative Regulation Of Leukocyte Activation Identical Protein Binding Negative Regulation Of Cell Adhesion Positive Regulation Of MAPK Cascade Response To External Biotic Stimulus Tumor Necrosis Factor Receptor Activity Negative Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Immune System Process Hormone Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Glucocorticoid Metabolic Process Growth Factor Activity Fibronectin Binding Macrophage Apoptotic Process BAT3 Complex Regulation Of Cell Adhesion Protein Folding Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Lymphocyte Proliferation Epidermal Growth Factor Receptor Binding Negative Regulation Of Mononuclear Cell Proliferation	Cellular Response To Nicotine Cellular Response To Interleukin-17 Mammary Gland Involution Negative Regulation Of Vitamin D Biosynthetic Process Regulation Of Hyaluronan Biosynthetic Process NF-kappaB P50/p65 Complex Positive Regulation Of Hyaluronan Biosynthetic Process I-kappaB/NF-kappaB Complex TRC Complex BAT3 Complex Binding Negative Regulation Of ERAD Pathway Regulation Of Vitamin Metabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Cellular Response To Angiotensin Actinin Binding Cellular Response To Interleukin-6 Antibacterial Innate Immune Response Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Macrophage Derived Foam Cell Differentiation Cellular Response To DsRNA Response To Interleukin-6 Negative Regulation Of Interleukin-12 Production Positive Regulation Of Lipid Storage Positive Regulation Of ERAD Pathway Negative Regulation Of Steroid Biosynthetic Process Response To Angiotensin Regulation Of ERAD Pathway Response To Muscle Stretch Positive Regulation Of Cholesterol Efflux Negative Regulation Of Steroid Metabolic Process Protein Targeting To ER Protein Insertion Into ER Membrane Regulation Of Macrophage Derived Foam Cell Differentiation Non-canonical NF-kappaB Signal Transduction Establishment Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Cholesterol Transport Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Response To Endoplasmic Reticulum Stress Protein Sequestering Activity Negative Regulation Of Cytokine Production Involved In Inflammatory Response Response To Nicotine Response To DsRNA Regulation Of Cholesterol Efflux Regulation Of Lipid Storage Negative Regulation Of Response To Endoplasmic Reticulum Stress Transcription Coactivator Binding Specific Granule Lumen Positive Regulation Of Transcription Initiation By RNA Polymerase II Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Lipid Biosynthetic Process
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