SGTA and HSP90AB1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SGTA	HSP90AB1
Gene Name		small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	heat shock protein 90kDa alpha (cytosolic), class B member 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleoplasm Cytoplasm Mitochondrion Cytosol COP9 Signalosome Cell Surface Membrane Inclusion Body Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Melanosome Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	UTP Binding CTP Binding Double-stranded RNA Binding Protein Binding ATP Binding GTP Binding Sulfonylurea Receptor Binding Kinase Binding Protein Kinase Binding MHC Class II Protein Complex Binding Nitric-oxide Synthase Regulator Activity TPR Domain Binding DATP Binding Ion Channel Binding Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	Biological_process Viral Process	Placenta Development Protein Folding Response To Unfolded Protein Axon Guidance Response To Salt Stress Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Heat Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Size Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Interleukin-4 Cellular Response To Organic Cyclic Compound Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cellular Response To Heat
Pathways			HSF1 activation Axon guidance Semaphorin interactions Inflammasomes Attenuation phase Cellular response to heat stress HSF1-dependent transactivation Uptake and actions of bacterial toxins The NLRP3 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Sema3A PAK dependent Axon repulsion Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Uptake and function of diphtheria toxin Innate Immune System
Drugs			Geldanamycin 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine Adenosine-5\'-Diphosphate Radicicol 4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE 4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL (5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONE (5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE
Diseases
GWAS
Protein-Protein Interactions		92 interactors: ADIPOQ AGR3 BAG6 BCL2L12 C1QA C1QTNF1 C1QTNF6 C3orf52 CARKD CCDC155 CD79B CD99 CDH15 COL1A2 COL8A2 CSF1 CST1 CTSL CXCL8 EFEMP1 EFEMP2 ERP27 EVA1B F11R FERD3L FIP1L1 FKBP7 FXYD7 GABARAPL2 GAL GHR GIP GPX7 GRN GYPA HSP90AA1 HSP90AB1 HSPA13 HSPA8 IGL IGLC1 IRF3 IRF5 ITPRIPL1 KRT6A KTN1 LAIR2 LAT MSMB MSTN MYDGF NME3 NXF1 PBXIP1 PCDHA4 PFN2 PIAS1 PPIB PPIC PPP1R3C PRAP1 PTN RARRES3 RPN1 SDC4 SERPINE1 SGCA SLPI SMAGP SOD3 SPP1 SPPL2A SRGN SYT11 SYT4 TFF3 TFRC TGFA TMEM174 TMEM31 TMPO TMUB2 TNFRSF13B TNFRSF1A TWSG1 TXNDC12 UBL4A UPK3A VIP WBP1L ZG16 ZG16B	41 interactors: ACD AKT1 ARHGAP1 CCT2 CDC37L1 CDKN2A CHORDC1 CHUK CLIC4 CSNK2A1 CYP17A1 DDX24 ESR1 FCHSD2 HIF1A IKBKB IKBKE IKBKG MAP3K14 MAP3K3 MAPK6 MKNK1 NR2C2 NR4A1 POT1 PPID SGTA SLC34A1 STARD13 STAT1 STAT3 TAF1D TBK1 TERF1 TINF2 TNNT1 TP53 TSSK6 USP50 WASL YWHAB
Entrez ID		6449	3326
HPRD ID		04568	06763
Ensembl ID		ENSG00000104969	ENSG00000096384
Uniprot IDs		O43765	B4DGL0 P08238 Q6PK50
PDB IDs		2VYI 4GOD 4GOE 4GOF	1QZ2 1UYM 3NMQ 3PRY
Enriched GO Terms of Interacting Partners?		Response To Stress Protein Heterotrimerization Extracellular Matrix Organization Extracellular Structure Organization Defense Response Regulation Of Immune System Process Protein Trimerization Macrophage Apoptotic Process Response To Wounding Regulation Of Secretion Immune System Process Regulation Of Protein Metabolic Process Anatomical Structure Development Regulation Of Cell Proliferation Protein Heterooligomerization Cell Communication Cell Surface Receptor Signaling Pathway Response To Stimulus Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Localization Positive Regulation Of Immune System Process Wound Healing Regulation Of Cellular Protein Metabolic Process Signaling Regulation Of Cellular Response To Heat Negative Regulation Of Proteolysis Positive Regulation Of Protein Modification Process Negative Regulation Of Protein Processing Developmental Process Multicellular Organismal Metabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Innate Immune Response Cellular Response To Stimulus Regulation Of Cytokine-mediated Signaling Pathway Extracellular Matrix Disassembly Myeloid Cell Apoptotic Process Response To Organic Substance Protein Folding Regulation Of Protein Processing Response To Lipid Regulation Of Developmental Growth Protein Insertion Into ER Membrane Inflammatory Cell Apoptotic Process Positive Regulation Of Cellular Metabolic Process System Development Regulation Of Immune Response Inflammatory Response Signal Transduction Positive Regulation Of Protein Metabolic Process	Positive Regulation Of Signal Transduction Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of I-kappaB Kinase/NF-kappaB Signaling Intracellular Signal Transduction Positive Regulation Of Metabolic Process I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Telomere Maintenance Positive Regulation Of Cellular Biosynthetic Process Regulation Of Telomere Maintenance Via Telomerase Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Catalytic Activity Negative Regulation Of DNA Replication Regulation Of Metabolic Process Regulation Of Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Telomere Maintenance Cellular Response To Stimulus Apoptotic Process Telomere Assembly Programmed Cell Death Immune Response-regulating Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cell Death Death Regulation Of Cell Death Regulation Of Immune System Process MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Signaling Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Transcription, DNA-templated Phosphorylation Homeostatic Process Regulation Of Organelle Organization Toll-like Receptor 4 Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Hormone Stimulus Regulation Of Apoptotic Process Negative Regulation Of Chromosome Organization Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of DNA Metabolic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Metabolic Process Innate Immune Response Positive Regulation Of Gene Expression Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		bag6 biochemically biophysical calorimetry compete connecting decided dimerisation glutamine haddock helices hydrophobic isothermal itc microscale mst nt paths perturbation resides solve tetratricopeptide thermophoresis titration tpr trc35 trimeric ubl ubl4a	1as atg aurothioglucose bpd bronchopulmonary bso buthionine comparatively cysteines cytoprotection h1299 hyperoxia hyperoxic nitrosylation oxidoreductase peroxiredoxin pharmacologically redox relies simplification smallest sulfoximine thiol thioredoxin trx trx1 vasculature
Tagcloud (Difference) ?		bag6 biochemically biophysical calorimetry compete connecting decided dimerisation glutamine haddock helices hydrophobic isothermal itc microscale mst nt paths perturbation resides solve tetratricopeptide thermophoresis titration tpr trc35 trimeric ubl ubl4a	1as atg aurothioglucose bpd bronchopulmonary bso buthionine comparatively cysteines cytoprotection h1299 hyperoxia hyperoxic nitrosylation oxidoreductase peroxiredoxin pharmacologically redox relies simplification smallest sulfoximine thiol thioredoxin trx trx1 vasculature
Tagcloud (Intersection) ?