SYT4 and STX2

Number of citations of the paper that reports this interaction (PMID 10397765)
9

Data Source:
HPRD (in vitro)

		SYT4	STX2
Gene Name		synaptotagmin IV	syntaxin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane Dense Core Granule Neuron Projection Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Extracellular Space Plasma Membrane Cell-cell Junction Synaptic Vesicle Cell Surface Endomembrane System Integral Component Of Membrane Basolateral Plasma Membrane Lamellipodium SNARE Complex Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	SNARE Binding Phosphatidylserine Binding Transporter Activity Calcium Ion Binding Clathrin Binding	SNARE Binding SNAP Receptor Activity Protein Binding Protein Dimerization Activity Calcium-dependent Protein Binding
	Biological Process	Exocytosis Neurotransmitter Secretion Negative Regulation Of Vesicle Fusion Negative Regulation Of Calcium Ion-dependent Exocytosis	Intracellular Protein Transport Signal Transduction Acrosome Reaction Ectoderm Development Organ Morphogenesis Cell Differentiation Regulation Of Blood Coagulation Synaptic Vesicle Fusion To Presynaptic Membrane Response To Hydroperoxide Vesicle Docking Protein Oligomerization Regulation Of Cytoskeleton Organization
Pathways
Drugs
Diseases
GWAS		Parkinson's disease ( 21738487)
Protein-Protein Interactions		10 interactors: NBR1 NRXN1 SGTA STX1A STX2 STX3 STX4 SYNCRIP SYT1 TFAP2B	12 interactors: CPLX2 SNAP23 SNAP25 STXBP1 STXBP2 SYT1 SYT4 SYT7 UNC13B VAMP2 VAMP3 VAPB
Entrez ID		6860	2054
HPRD ID		02519	11816
Ensembl ID		ENSG00000132872	ENSG00000111450
Uniprot IDs		B4DEU3 Q9H2B2	P32856
PDB IDs		1UGK
Enriched GO Terms of Interacting Partners?		Neurotransmitter Secretion Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Neurotransmitter Levels Synaptic Vesicle Exocytosis Neurotransmitter Transport Vesicle Localization Vesicle Docking Membrane Docking Positive Regulation Of Synaptic Transmission Synaptic Vesicle Transport Vesicle Fusion Organelle Localization Establishment Of Vesicle Localization Secretion By Cell Organelle Fusion Synaptic Transmission Secretion Regulation Of Synaptic Transmission Establishment Of Organelle Localization Exocytosis Positive Regulation Of Protein Localization To Plasma Membrane Membrane Fusion Cell-cell Signaling Regulation Of Insulin Secretion Vesicle Organization Regulation Of Cellular Localization Regulation Of Protein Localization To Plasma Membrane Regulation Of Peptide Hormone Secretion Positive Regulation Of Exocytosis Regulation Of Hormone Secretion Regulation Of Secretion Positive Regulation Of Protein Localization To Cell Surface Regulation Of Protein Localization Membrane Organization Regulation Of Protein Secretion Regulation Of Exocytosis Regulation Of Protein Localization To Cell Surface Protein Complex Assembly Response To Hydroperoxide Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Glutamate Secretion Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Behavior Establishment Of Localization In Cell Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Protein Transport Cellular Protein Localization Regulation Of Establishment Of Protein Localization Regulation Of Regulated Secretory Pathway	Exocytosis Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Secretion By Cell Neurotransmitter Transport Secretion Regulation Of Exocytosis Vesicle Docking Vesicle-mediated Transport Membrane Docking Regulation Of Secretion Synaptic Vesicle Transport Synaptic Vesicle Exocytosis Vesicle Docking Involved In Exocytosis Establishment Of Localization In Cell Glutamate Secretion Cellular Localization Regulation Of Cellular Localization Regulation Of Vesicle-mediated Transport Establishment Of Vesicle Localization Vesicle Localization Cell-cell Signaling Establishment Of Organelle Localization Acid Secretion Organelle Localization Dicarboxylic Acid Transport Vesicle Organization Regulation Of Synaptic Transmission Synaptic Transmission Leukocyte Degranulation Transport Synaptic Vesicle Priming Vesicle Fusion Amino Acid Transport Regulation Of Calcium Ion-dependent Exocytosis Regulated Secretory Pathway Regulation Of Synaptic Plasticity Positive Regulation Of Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Organelle Fusion Membrane Organization Positive Regulation Of Synaptic Transmission Carboxylic Acid Transport Organic Acid Transport Anion Transport Membrane Fusion Regulation Of Vesicle Fusion Leukocyte Activation Involved In Immune Response Endomembrane System Organization Organic Anion Transport
Tagcloud ?			alter apc apoptotic bcl2 challenged chop contributing cytoprotective decreasing dr5 enterohemorrhagic fold hemolytic hsp40 kidneys later producing ribotoxic rodentium saline shiga spliced toxigenic toxins transcripts untreated uremic xbp1
Tagcloud (Difference) ?			alter apc apoptotic bcl2 challenged chop contributing cytoprotective decreasing dr5 enterohemorrhagic fold hemolytic hsp40 kidneys later producing ribotoxic rodentium saline shiga spliced toxigenic toxins transcripts untreated uremic xbp1
Tagcloud (Intersection) ?