SGTA and IRF5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		SGTA	IRF5
Description		small glutamine rich tetratricopeptide repeat co-chaperone alpha	interferon regulatory factor 5
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane TRC Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Identical Protein Binding Molecular Adaptor Activity BAT3 Complex Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Identical Protein Binding Sequence-specific DNA Binding Protein Serine/threonine Kinase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane ERAD Pathway Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of ERAD Pathway Positive Regulation Of ERAD Pathway Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Peptidoglycan Cellular Response To Muramyl Dipeptide Cellular Response To Virus
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Interferon gamma signaling Interferon alpha/beta signaling SLC15A4:TASL-dependent IRF5 activation
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Autoimmune traits (pleiotropy) ( 30572963) Behcet's disease ( 33393726) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Diffuse cutaneous systemic sclerosis ( 29293537) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163) Limited cutaneous systemic scleroderma ( 29293537) Liver enzyme levels (alkaline phosphatase) ( 33972514) Primary biliary cholangitis ( 20639880 26394269 21399635) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 30423114 24390342 23143596 30572963 21156761) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sjögren's syndrome ( 24097067 28076899) Systemic lupus erythematosus ( 26502338 28714469 32771030 27399966 33272962 26663301 18204098 18204446 19838193 19838195 21408207 23053960 23273568 26606652 24871463) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 24387989 20383147 31672989 21750679 30572963 21779181 30247649 29293537) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Ulcerative colitis ( 23128233 28067908 21297633 26398853)
Interacting Genes		182 interacting genes: ADAM21 ADIPOQ ADRM1 AGR2 AGR3 AOC3 BAG6 BCL2L12 BTC C1QA C1QL4 C1QTNF1 C1QTNF5 C1QTNF6 C3orf52 C5orf46 CD79B CD99 CD99L2 CDH15 CDSN CHRNG COL1A2 COL8A2 CREB3L3 CSF1 CST1 CTAG1A CTAG1B CTSL CXCL8 CYB5R1 DEFA6 DEFB131A DKK3 DMKN EDA2R EDAR EFEMP1 EFEMP2 ERP27 ERP29 ETNK1 EVA1B F11R FERD3L FGF21 FIP1L1 FKBP7 FSTL1 FXYD2 FXYD7 FZD7 GABARAPL2 GAL GALP GHR GIP GPX7 GRN GUCA2A GYPA HSP90AA1 HSP90AB1 HSPA13 HSPA4 IER3 IGFBP6 IGL IGLC1 IL6ST IRF3 IRF5 ITPRIPL1 KASH5 KCNA1 KCNA10 KCNE5 KLHL20 KRT6A KTN1 LAIR2 LAT LCN2 LDLRAD4 LSMEM2 MRAP2 MS4A3 MSMB MSTN MYDGF MYOC NAXD NME3 NPVF NR3C1 NRSN2 NXF1 PAGE3 PBXIP1 PCDHA4 PCDHGA4 PFN2 PGLYRP2 PGR PIAS1 PLAAT4 PMEPA1 PODXL PPIB PPIC PPP1R3C PRAP1 PRB4 PRRG2 PSORS1C2 PTN PYY RCN1 RNASE10 RNF144A RNF144B RNF170 RPN1 SDC4 SDF2L1 SERPINE1 SERPINI2 SGCA SGTB SHISA4 SHISA5 SLPI SMAGP SMIM14 SMIM5 SOD3 SPINK9 SPN SPP1 SPPL2A SRGN SRL STMP1 SUOX SYT11 SYT4 TFF3 TFRC TGFA TIAM1 TMEM154 TMEM174 TMEM230 TMEM31 TMEM98 TMPO TMPRSS11D TMUB2 TNFRSF10C TNFRSF13B TNFRSF19 TNFRSF1A TNFRSF21 TNFSF12 TRIM5 TWSG1 TXNDC12 UBL4A UBQLN2 UPK3A USP14 USP5 USP9X VIP WBP1L WFDC12 WFDC13 WFDC5 ZBTB8B ZG16 ZG16B	17 interacting genes: ALPI COPS3 CREBBP EP300 HDAC1 IKBKE IRF3 MAVS MYD88 NCOR2 SGTA SIN3A TBK1 TRAF6 TRIM15 TRIM21 XPO1
Entrez ID		6449	3663
HPRD ID		04568	06240
Ensembl ID		ENSG00000104969	ENSG00000128604
Uniprot IDs		O43765	A0A0G2USB5 B7Z1M2 Q13568
PDB IDs		2VYI 4CPG 4GOD 4GOE 4GOF	3DSH
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Protein Binding Endoplasmic Reticulum Lumen Response To Bacterium Defense Response To Bacterium Collagen Trimer Response To Stress Membrane Response To Other Organism Antimicrobial Humoral Response Endoplasmic Reticulum Immune System Process Regulation Of Immune System Process Humoral Immune Response Peptidase Inhibitor Activity Negative Regulation Of Cell Activation Positive Regulation Of Leukocyte Migration Serine-type Endopeptidase Inhibitor Activity Defense Response Extracellular Exosome Defense Response To Symbiont Negative Regulation Of Proteasomal Protein Catabolic Process Antibacterial Humoral Response Plasma Membrane Immune Response Defense Response To Other Organism Negative Regulation Of Leukocyte Activation Identical Protein Binding Negative Regulation Of Cell Adhesion Positive Regulation Of MAPK Cascade Response To External Biotic Stimulus Tumor Necrosis Factor Receptor Activity Negative Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Immune System Process Hormone Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Glucocorticoid Metabolic Process Growth Factor Activity Fibronectin Binding Macrophage Apoptotic Process BAT3 Complex Regulation Of Cell Adhesion Protein Folding Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Lymphocyte Proliferation Epidermal Growth Factor Receptor Binding Negative Regulation Of Mononuclear Cell Proliferation	Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Activation Of Innate Immune Response Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Type I Interferon-mediated Signaling Pathway Positive Regulation Of Defense Response Canonical NF-kappaB Signal Transduction Interferon-mediated Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Activation Of Immune Response Regulation Of Defense Response Defense Response To Virus Innate Immune Response-activating Signaling Pathway Positive Regulation Of Immune Response Regulation Of Immune Response Positive Regulation Of Type I Interferon-mediated Signaling Pathway Response To Virus Antiviral Innate Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Immune Response-activating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway MRNA Transcription Regulation Of Signal Transduction Positive Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Histone H3K27 Acetyltransferase Activity Positive Regulation Of Response To Cytokine Stimulus Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cytokine Production Protein-containing Complex Negative Regulation Of RNA Metabolic Process Positive Regulation Of Cell Communication Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Signaling
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