SGTA and PODXL

Number of citations: 82 (PubMedID 36949045)
Data Source: BioGRID (two hybrid)

		SGTA	PODXL
Name		small glutamine rich tetratricopeptide repeat co-chaperone alpha	podocalyxin like
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane TRC Complex	Ruffle Extracellular Space Nucleolus Cytoplasm Endoplasmic Reticulum Plasma Membrane Microvillus Membrane Apical Plasma Membrane Lamellipodium Filopodium Microvillus Membrane Centriolar Satellite Slit Diaphragm Cell Projection Membrane Raft Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding Molecular Adaptor Activity BAT3 Complex Binding	Protein Binding
	Biological Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane ERAD Pathway Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of ERAD Pathway Positive Regulation Of ERAD Pathway Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Cell Adhesion Negative Regulation Of Cell Adhesion Cell Migration Regulation Of Cell-cell Adhesion Negative Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Migration Regulation Of Microvillus Assembly Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Podocyte Development Epithelial Tube Formation
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	None
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847 )	Alcohol dependence symptom count ( 27151647 ) Diastolic blood pressure ( 27841878 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Hypertension ( 28273873 ) Idiopathic dilated cardiomyopathy ( 29495422 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Pulse pressure ( 30578418 ) Schizophrenia ( 25056061 ) Systolic blood pressure ( 27841878 30578418 )
Interacting Genes		182 interacting genes: ADAM21 ADIPOQ ADRM1 AGR2 AGR3 AOC3 BAG6 BCL2L12 BTC C1QA C1QL4 C1QTNF1 C1QTNF5 C1QTNF6 C3orf52 C5orf46 CD79B CD99 CD99L2 CDH15 CDSN CHRNG COL1A2 COL8A2 CREB3L3 CSF1 CST1 CTAG1A CTAG1B CTSL CXCL8 CYB5R1 DEFA6 DEFB131A DKK3 DMKN EDA2R EDAR EFEMP1 EFEMP2 ERP27 ERP29 ETNK1 EVA1B F11R FERD3L FGF21 FIP1L1 FKBP7 FSTL1 FXYD2 FXYD7 FZD7 GABARAPL2 GAL GALP GHR GIP GPX7 GRN GUCA2A GYPA HSP90AA1 HSP90AB1 HSPA13 HSPA4 IER3 IGFBP6 IGL IGLC1 IL6ST IRF3 IRF5 ITPRIPL1 KASH5 KCNA1 KCNA10 KCNE5 KLHL20 KRT6A KTN1 LAIR2 LAT LCN2 LDLRAD4 LSMEM2 MRAP2 MS4A3 MSMB MSTN MYDGF MYOC NAXD NME3 NPVF NR3C1 NRSN2 NXF1 PAGE3 PBXIP1 PCDHA4 PCDHGA4 PFN2 PGLYRP2 PGR PIAS1 PLAAT4 PMEPA1 PODXL PPIB PPIC PPP1R3C PRAP1 PRB4 PRRG2 PSORS1C2 PTN PYY RCN1 RNASE10 RNF144A RNF144B RNF170 RPN1 SDC4 SDF2L1 SERPINE1 SERPINI2 SGCA SGTB SHISA4 SHISA5 SLPI SMAGP SMIM14 SMIM5 SOD3 SPINK9 SPN SPP1 SPPL2A SRGN SRL STMP1 SUOX SYT11 SYT4 TFF3 TFRC TGFA TIAM1 TMEM154 TMEM174 TMEM230 TMEM31 TMEM98 TMPO TMPRSS11D TMUB2 TNFRSF10C TNFRSF13B TNFRSF19 TNFRSF1A TNFRSF21 TNFSF12 TRIM5 TWSG1 TXNDC12 UBL4A UBQLN2 UPK3A USP14 USP5 USP9X VIP WBP1L WFDC12 WFDC13 WFDC5 ZBTB8B ZG16 ZG16B	5 interacting genes: NHERF2 SELL SGTA SGTB UBQLN2
Entrez ID		6449	5420
HPRD ID		04568	04025
Ensembl ID		ENSG00000104969	ENSG00000128567
Uniprot IDs		O43765	O00592 Q96N83
PDB IDs		2VYI 4CPG 4GOD 4GOE 4GOF	Not available
GO Terms Enriched among Interactors		Extracellular Region Extracellular Space Protein Binding Endoplasmic Reticulum Lumen Response To Bacterium Defense Response To Bacterium Collagen Trimer Response To Stress Membrane Response To Other Organism Antimicrobial Humoral Response Endoplasmic Reticulum Immune System Process Regulation Of Immune System Process Humoral Immune Response Peptidase Inhibitor Activity Negative Regulation Of Cell Activation Positive Regulation Of Leukocyte Migration Serine-type Endopeptidase Inhibitor Activity Defense Response Extracellular Exosome Defense Response To Symbiont Negative Regulation Of Proteasomal Protein Catabolic Process Antibacterial Humoral Response Plasma Membrane Immune Response Defense Response To Other Organism Negative Regulation Of Leukocyte Activation Identical Protein Binding Negative Regulation Of Cell Adhesion Positive Regulation Of MAPK Cascade Response To External Biotic Stimulus Tumor Necrosis Factor Receptor Activity Negative Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Immune System Process Hormone Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Glucocorticoid Metabolic Process Growth Factor Activity Fibronectin Binding Macrophage Apoptotic Process BAT3 Complex Regulation Of Cell Adhesion Protein Folding Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Lymphocyte Proliferation Epidermal Growth Factor Receptor Binding Negative Regulation Of Mononuclear Cell Proliferation	TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Molecular Adaptor Activity Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Response To Endoplasmic Reticulum Stress Protein Targeting To Membrane Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Localization Within Membrane Positive Regulation Of Proteasomal Protein Catabolic Process Type 2 Metabotropic Glutamate Receptor Binding Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Type 3 Metabotropic Glutamate Receptor Binding BAT3 Complex Binding Identical Protein Binding Negative Regulation Of Clathrin-dependent Endocytosis Glycosphingolipid Binding Positive Regulation Of Proteolysis Establishment Of Protein Localization To Membrane Protein Targeting Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of ERAD Pathway Response To Endoplasmic Reticulum Stress Oligosaccharide Binding Establishment Of Protein Localization To Organelle Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of Receptor Internalization Regulation Of Clathrin-dependent Endocytosis Leukocyte Tethering Or Rolling Regulation Of Protein Catabolic Process Regulation Of Proteolysis Sialic Acid Binding Leukocyte Adhesion To Vascular Endothelial Cell Protein Heterooligomerization Protein Insertion Into ER Membrane Proteasomal Protein Catabolic Process Negative Regulation Of Receptor-mediated Endocytosis Mitochondrial Small Ribosomal Subunit Cellular Localization Protein-membrane Adaptor Activity