SGTA and TNFRSF13B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, two hybrid)

		SGTA	TNFRSF13B
Description		small glutamine rich tetratricopeptide repeat co-chaperone alpha	TNF receptor superfamily member 13B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane TRC Complex	Plasma Membrane Membrane
	Molecular Function	Protein Binding Identical Protein Binding Molecular Adaptor Activity BAT3 Complex Binding	Protein Binding Signaling Receptor Activity
	Biological Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane ERAD Pathway Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of ERAD Pathway Positive Regulation Of ERAD Pathway Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	B Cell Homeostasis Hematopoietic Progenitor Cell Differentiation Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Negative Regulation Of B Cell Proliferation
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	TNFs bind their physiological receptors
Drugs
Diseases			Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Albumin-globulin ratio ( 29403010) Apolipoprotein A1 levels ( 32203549) Diabetic retinopathy ( 21441570) Granulocyte percentage of myeloid white cells ( 27863252) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hematological and biochemical traits ( 20139978) Hematology traits ( 23303382) IgG levels ( 22673310) Immunoglobulin light chain (AL) amyloidosis ( 28025584) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monoclonal gammopathy of undetermined significance ( 30737484) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Multiple myeloma ( 32569378 33875642 23955597 26007630) Multiple myeloma and monoclonal gammopathy ( 26007630) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 22558069 29403010) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Serum albumin levels ( 29403010) Serum total protein levels ( 23022100 29403010) Sodium levels ( 29403010) Systemic lupus erythematosus ( 33272962) Tonsillectomy ( 27182965 28928442) White blood cell count ( 32888494)
Interacting Genes		182 interacting genes: ADAM21 ADIPOQ ADRM1 AGR2 AGR3 AOC3 BAG6 BCL2L12 BTC C1QA C1QL4 C1QTNF1 C1QTNF5 C1QTNF6 C3orf52 C5orf46 CD79B CD99 CD99L2 CDH15 CDSN CHRNG COL1A2 COL8A2 CREB3L3 CSF1 CST1 CTAG1A CTAG1B CTSL CXCL8 CYB5R1 DEFA6 DEFB131A DKK3 DMKN EDA2R EDAR EFEMP1 EFEMP2 ERP27 ERP29 ETNK1 EVA1B F11R FERD3L FGF21 FIP1L1 FKBP7 FSTL1 FXYD2 FXYD7 FZD7 GABARAPL2 GAL GALP GHR GIP GPX7 GRN GUCA2A GYPA HSP90AA1 HSP90AB1 HSPA13 HSPA4 IER3 IGFBP6 IGL IGLC1 IL6ST IRF3 IRF5 ITPRIPL1 KASH5 KCNA1 KCNA10 KCNE5 KLHL20 KRT6A KTN1 LAIR2 LAT LCN2 LDLRAD4 LSMEM2 MRAP2 MS4A3 MSMB MSTN MYDGF MYOC NAXD NME3 NPVF NR3C1 NRSN2 NXF1 PAGE3 PBXIP1 PCDHA4 PCDHGA4 PFN2 PGLYRP2 PGR PIAS1 PLAAT4 PMEPA1 PODXL PPIB PPIC PPP1R3C PRAP1 PRB4 PRRG2 PSORS1C2 PTN PYY RCN1 RNASE10 RNF144A RNF144B RNF170 RPN1 SDC4 SDF2L1 SERPINE1 SERPINI2 SGCA SGTB SHISA4 SHISA5 SLPI SMAGP SMIM14 SMIM5 SOD3 SPINK9 SPN SPP1 SPPL2A SRGN SRL STMP1 SUOX SYT11 SYT4 TFF3 TFRC TGFA TIAM1 TMEM154 TMEM174 TMEM230 TMEM31 TMEM98 TMPO TMPRSS11D TMUB2 TNFRSF10C TNFRSF13B TNFRSF19 TNFRSF1A TNFRSF21 TNFSF12 TRIM5 TWSG1 TXNDC12 UBL4A UBQLN2 UPK3A USP14 USP5 USP9X VIP WBP1L WFDC12 WFDC13 WFDC5 ZBTB8B ZG16 ZG16B	7 interacting genes: CAMLG SGTA TNFSF13 TNFSF13B TRAF2 TRAF5 TRAF6
Entrez ID		6449	23495
HPRD ID		04568	05365
Ensembl ID		ENSG00000104969	ENSG00000240505
Uniprot IDs		O43765	O14836 Q4ACX1
PDB IDs		2VYI 4CPG 4GOD 4GOE 4GOF	1XU1 1XUT
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Protein Binding Endoplasmic Reticulum Lumen Response To Bacterium Defense Response To Bacterium Collagen Trimer Response To Stress Membrane Response To Other Organism Antimicrobial Humoral Response Endoplasmic Reticulum Immune System Process Regulation Of Immune System Process Humoral Immune Response Peptidase Inhibitor Activity Negative Regulation Of Cell Activation Positive Regulation Of Leukocyte Migration Serine-type Endopeptidase Inhibitor Activity Defense Response Extracellular Exosome Defense Response To Symbiont Negative Regulation Of Proteasomal Protein Catabolic Process Antibacterial Humoral Response Plasma Membrane Immune Response Defense Response To Other Organism Negative Regulation Of Leukocyte Activation Identical Protein Binding Negative Regulation Of Cell Adhesion Positive Regulation Of MAPK Cascade Response To External Biotic Stimulus Tumor Necrosis Factor Receptor Activity Negative Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Immune System Process Hormone Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Glucocorticoid Metabolic Process Growth Factor Activity Fibronectin Binding Macrophage Apoptotic Process BAT3 Complex Regulation Of Cell Adhesion Protein Folding Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Lymphocyte Proliferation Epidermal Growth Factor Receptor Binding Negative Regulation Of Mononuclear Cell Proliferation	Tumor Necrosis Factor Receptor Binding CD40 Receptor Complex CD40 Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Adaptive Immune Response Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Adaptive Immune Response Lymphocyte Homeostasis Leukocyte Homeostasis Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Regulation Of Immunoglobulin Production Thioesterase Binding Positive Regulation Of JUN Kinase Activity Cytoplasmic Side Of Plasma Membrane Negative Regulation Of Catabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Cytokine-mediated Signaling Pathway Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Multicellular Organismal-level Homeostasis Positive Regulation Of Leukocyte Proliferation Cell Surface Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Homeostasis Of Number Of Cells B Cell Homeostasis Protein Insertion Into ER Membrane Positive Regulation Of T Cell Cytokine Production Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of Lymphocyte Mediated Immunity Non-canonical NF-kappaB Signal Transduction Positive Regulation Of MAP Kinase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Interleukin-2 Production Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Immune Response Regulation Of T Cell Cytokine Production Regulation Of Mononuclear Cell Proliferation Positive Regulation Of B Cell Proliferation Positive Regulation Of Immune Effector Process Regulation Of Leukocyte Proliferation Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Signal Transduction
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