NACA

Name	nascent polypeptide associated complex subunit alpha
Structure
Interactors	17 interactors: APLP1 CCDC90B FADD FOS FUNDC2 IGSF21 JUN LRIF1 MDM2 PPP1R18 PTEN SMYD1 SPP1 TBP TXLNA UCHL5 ZHX1
GO Annotations	Cellular Component	Nucleus Cytoplasm Nascent Polypeptide-associated Complex Extracellular Exosome
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding Unfolded Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cardiac Ventricle Development Translation Protein Targeting To Membrane Negative Regulation Of Striated Muscle Cell Apoptotic Process Protein Transport Wound Healing Skeletal Muscle Tissue Regeneration Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Skeletal Muscle Tissue Growth Regulation Of Skeletal Muscle Fiber Development Heart Trabecula Morphogenesis Negative Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis
GWAS	Alanine aminotransferase levels ( 34315874 ) Aspartate aminotransferase levels ( 34315874 ) Asthma ( 31619474 ) Atrial fibrillation ( 29892015 30061737 ) Diastolic blood pressure ( 30224653 ) JT interval ( 29874175 ) QRS duration ( 30012220 )
Entrez ID	4666
HPRD ID	03137
Ensembl ID	ENSG00000196531
Uniprot IDs	E9PAV3 Q13765
PDB IDs	3LKX 3MCB 3MCE 7QWQ 7QWR 7QWS 8P2K 9F1B 9F1C 9F1D 9FQ0
GO Terms Enriched among Interactors ?	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Factor AP-1 Complex Receptor Serine/threonine Kinase Binding Forebrain Morphogenesis Response To Steroid Hormone Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of RNA Metabolic Process Synapse Maturation Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Response To Immobilization Stress Response To Muscle Stretch SMAD Protein Signal Transduction R-SMAD Binding Negative Regulation Of Neuron Projection Development Regulation Of Primary Metabolic Process Regulation Of Smooth Muscle Cell Proliferation Regulation Of Proteolysis Alpha-2B Adrenergic Receptor Binding Developmental Process Response To Mechanical Stimulus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Medium-term Memory Integrated Stress Response Signaling Cellular Response To Prolactin RNA Polymerase II-specific DNA-binding Transcription Factor Binding Enzyme Binding Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Formaldehyde Cellular Response To Vitamin B1 Response To Cocaine Negative Regulation Of Cell Projection Organization Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Proteolysis Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Axonogenesis Cell Death Apoptotic Process Cytosolic MRNA Polyadenylation Alpha-2C Adrenergic Receptor Binding Animal Organ Development Programmed Cell Death