NACA and IGSF21

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NACA	IGSF21
Gene Name		nascent polypeptide-associated complex alpha subunit	immunoglobin superfamily, member 21
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Nascent Polypeptide-associated Complex Extracellular Vesicular Exosome	Extracellular Region
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding TBP-class Protein Binding
	Biological Process	Cardiac Ventricle Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Translation Negative Regulation Of Striated Muscle Cell Apoptotic Process Protein Transport Viral Process Skeletal Muscle Tissue Regeneration Positive Regulation Of Skeletal Muscle Tissue Growth Regulation Of Skeletal Muscle Fiber Development Heart Trabecula Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Pathways
Drugs
Diseases
GWAS			Diabetic retinopathy ( 21441570) Erectile dysfunction and prostate cancer treatment ( 20932654)
Protein-Protein Interactions		17 interactors: APLP1 BTF3 CCDC90B FADD FOS FUNDC2 IGSF21 JUN LRIF1 MDM2 NUPR1 SMYD1 SPP1 TBP TXLNA UCHL5 ZHX1	32 interactors: ALDH2 ANXA3 ATF3 BCR BTBD2 CRCT1 DGKD EPB41L3 ERH ETHE1 GADD45A GIPC2 GSK3B GSTM4 HSPB1 KRAS MAD2L1BP NACA NREP PAEP PAFAH1B3 PCDHA4 PRMT1 PSMD11 RPP14 S100A8 SEPHS1 SERPINB9 SULT1E1 TMSB4X TRBV2 UBE2V2
Entrez ID		4666	84966
HPRD ID		03137	11309
Ensembl ID		ENSG00000196531	ENSG00000117154
Uniprot IDs		B2R4P8 Q13765	Q96ID5
PDB IDs		3LKX 3MCB 3MCE
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Skeletal Muscle Cell Differentiation TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Myeloid Cell Differentiation Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Myeloid Leukocyte Differentiation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Nucleobase-containing Compound Metabolic Process Skeletal Muscle Tissue Development Cellular Macromolecule Biosynthetic Process Activation Of Innate Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Defense Response Macromolecule Biosynthetic Process Skeletal Muscle Organ Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Response To Organic Cyclic Compound Response To Extracellular Stimulus Immune Response-regulating Signaling Pathway Immune System Process Regulation Of Myeloid Cell Differentiation Organ Development Response To Toxic Substance Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Innate Immune Response Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Response To Reactive Oxygen Species Apoptotic Process Programmed Cell Death Cellular Response To Extracellular Stimulus Response To Mechanical Stimulus	Response To Wounding Regulation Of Apoptotic Process Regulation Of Cell Death Wound Healing Positive Regulation Of Protein Metabolic Process Response To Stress Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Negative Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Response To Stimulus Developmental Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Response To Xenobiotic Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development ERBB Signaling Pathway Regulation Of Proteolysis Programmed Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Death Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Death Cellular Response To Stimulus Blood Coagulation Platelet Activation Hemostasis Regulation Of Protein Kinase Activity Response To Biotic Stimulus Multicellular Organismal Development Positive Regulation Of Catalytic Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Kinase Activity Positive Regulation Of Rac GTPase Activity Positive Regulation Of Endothelial Cell Migration Regulation Of Neuronal Synaptic Plasticity Regulation Of Kinase Activity Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Growth
Tagcloud ?		ap apd20 apd50 apd90 atrial caf cal calibrate calibrated determines deviating electrophysiology explaining hampering inter ionic ito k1 kur mimic nak recordings rhythm sr trabeculae triangulation underlies variability yielding
Tagcloud (Difference) ?		ap apd20 apd50 apd90 atrial caf cal calibrate calibrated determines deviating electrophysiology explaining hampering inter ionic ito k1 kur mimic nak recordings rhythm sr trabeculae triangulation underlies variability yielding
Tagcloud (Intersection) ?