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NACA and UCHL5
Number of citations of the paper that reports this interaction (PMID
21800051
)
0
Data Source:
BioGRID
(pull down)
NACA
UCHL5
Gene Name
nascent polypeptide-associated complex alpha subunit
ubiquitin carboxyl-terminal hydrolase L5
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Nascent Polypeptide-associated Complex
Extracellular Vesicular Exosome
Proteasome Complex
Nucleus
Cytosol
Ino80 Complex
Molecular Function
DNA Binding
Transcription Coactivator Activity
Protein Binding
TBP-class Protein Binding
Ubiquitin-specific Protease Activity
Endopeptidase Inhibitor Activity
Protein Binding
Omega Peptidase Activity
Poly(A) RNA Binding
Proteasome Binding
Biological Process
Cardiac Ventricle Development
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Translation
Negative Regulation Of Striated Muscle Cell Apoptotic Process
Protein Transport
Viral Process
Skeletal Muscle Tissue Regeneration
Positive Regulation Of Skeletal Muscle Tissue Growth
Regulation Of Skeletal Muscle Fiber Development
Heart Trabecula Morphogenesis
Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development
Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis
DNA Repair
DNA Recombination
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Ubiquitin-dependent Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Endopeptidase Activity
Protein Deubiquitination
Lateral Ventricle Development
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Midbrain Development
Forebrain Morphogenesis
Regulation Of Proteasomal Protein Catabolic Process
Pathways
Loss of Function of TGFBR2 in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
Downregulation of TGF-beta receptor signaling
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGF-beta receptor signaling activates SMADs
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Cannabis dependence (
21668797
)
Protein-Protein Interactions
17 interactors:
APLP1
BTF3
CCDC90B
FADD
FOS
FUNDC2
IGSF21
JUN
LRIF1
MDM2
NUPR1
SMYD1
SPP1
TBP
TXLNA
UCHL5
ZHX1
96 interactors:
ACTN4
ADRM1
ANP32B
ANP32E
ANXA1
ANXA4
ANXA7
ANXA8
APP
ARG1
ASPRV1
CALM1
CAP1
CAPZA1
CASP14
CDSN
CFL1
CSTA
DSC1
DSC3
DSP
DUSP14
EEF1G
EEF2
EIF4A1
EPPK1
FLG
GSTM3
HAUS7
HBA1
HBA2
HBB
HIST1H4A
HIST1H4B
HIST1H4C
HIST1H4D
HIST1H4E
HIST1H4F
HIST1H4H
HIST1H4I
HIST1H4J
HIST1H4K
HIST1H4L
HIST2H4A
HIST2H4B
HIST4H4
HSPB1
IDE
IGHG1
IVL
KDM1A
KRT12
KRT19
KRT26
KRT28
KRT73
KRT78
KRT80
LMNA
NACA
NFRKB
PJA1
PKM
PKP1
PLA2G2A
PNP
POF1B
PRDX6
PSMD8
RAB7A
RBCK1
RFFL
S100A14
S100A16
S100A7
SERPINB12
SERPINB3
SERPINB5
SET
SMAD2
SMAD3
SMAD7
TGM3
TPI1
TRIM27
TRIM46
TRIM54
TRIM55
TRIM63
TUBA4A
TXN
TXN2
UBE3A
USP28
YWHAZ
ZBED1
Entrez ID
4666
51377
HPRD ID
03137
10293
Ensembl ID
ENSG00000196531
ENSG00000116750
Uniprot IDs
B2R4P8
Q13765
Q9Y5K5
PDB IDs
3LKX
3MCB
3MCE
3A7S
3IHR
3RII
3RIS
3TB3
Enriched GO Terms of Interacting Partners
?
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
RNA Metabolic Process
Positive Regulation Of Myeloid Leukocyte Differentiation
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Gene Expression
Regulation Of RNA Metabolic Process
Skeletal Muscle Cell Differentiation
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of Myeloid Cell Differentiation
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor Signaling Pathway
Regulation Of Myeloid Leukocyte Differentiation
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Nucleobase-containing Compound Metabolic Process
Skeletal Muscle Tissue Development
Cellular Macromolecule Biosynthetic Process
Activation Of Innate Immune Response
Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Biosynthetic Process
Defense Response
Macromolecule Biosynthetic Process
Skeletal Muscle Organ Development
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Response To Organic Cyclic Compound
Response To Extracellular Stimulus
Immune Response-regulating Signaling Pathway
Immune System Process
Regulation Of Myeloid Cell Differentiation
Organ Development
Response To Toxic Substance
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Innate Immune Response
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Response To Reactive Oxygen Species
Apoptotic Process
Programmed Cell Death
Cellular Response To Extracellular Stimulus
Response To Mechanical Stimulus
Histone H4-K20 Demethylation
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Hematopoietic Progenitor Cell Differentiation
DNA Replication-dependent Nucleosome Assembly
Regulation Of Megakaryocyte Differentiation
DNA Methylation On Cytosine
Chromatin Silencing At RDNA
Regulation Of Hematopoietic Progenitor Cell Differentiation
Histone Exchange
Histone Lysine Demethylation
Histone Demethylation
Protein Demethylation
CENP-A Containing Nucleosome Assembly
Chromatin Silencing
DNA Replication-independent Nucleosome Assembly
Demethylation
Centromere Complex Assembly
ATP-dependent Chromatin Remodeling
Negative Regulation Of Gene Expression, Epigenetic
Gene Silencing
DNA Methylation
Nucleosome Organization
Nucleosome Assembly
Chromatin Assembly
Telomere Maintenance
Negative Regulation Of Myeloid Cell Differentiation
DNA Modification
Chromatin Assembly Or Disassembly
Protein-DNA Complex Assembly
Protein Complex Assembly
Regulation Of Gene Expression, Epigenetic
DNA Packaging
Cellular Component Assembly
Regulation Of Myeloid Cell Differentiation
DNA Conformation Change
Chromatin Remodeling
Negative Regulation Of Cellular Metabolic Process
Regulation Of Immune System Process
Cellular Macromolecular Complex Assembly
Negative Regulation Of Cell Differentiation
Mitotic Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Immune System Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Histone Modification
Negative Regulation Of Gene Expression
Keratinocyte Differentiation
Cellular Protein Metabolic Process
Homeostatic Process
Tagcloud
?
ap
apd20
apd50
apd90
atrial
caf
cal
calibrate
calibrated
determines
deviating
electrophysiology
explaining
hampering
inter
ionic
ito
k1
kur
mimic
nak
recordings
rhythm
sr
trabeculae
triangulation
underlies
variability
yielding
Tagcloud (Difference)
?
ap
apd20
apd50
apd90
atrial
caf
cal
calibrate
calibrated
determines
deviating
electrophysiology
explaining
hampering
inter
ionic
ito
k1
kur
mimic
nak
recordings
rhythm
sr
trabeculae
triangulation
underlies
variability
yielding
Tagcloud (Intersection)
?