NACA and ZHX1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NACA	ZHX1
Gene Name		nascent polypeptide-associated complex alpha subunit	zinc fingers and homeoboxes 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Nascent Polypeptide-associated Complex Extracellular Vesicular Exosome	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding TBP-class Protein Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Cardiac Ventricle Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Translation Negative Regulation Of Striated Muscle Cell Apoptotic Process Protein Transport Viral Process Skeletal Muscle Tissue Regeneration Positive Regulation Of Skeletal Muscle Tissue Growth Regulation Of Skeletal Muscle Fiber Development Heart Trabecula Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Cell Differentiation Negative Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: APLP1 BTF3 CCDC90B FADD FOS FUNDC2 IGSF21 JUN LRIF1 MDM2 NUPR1 SMYD1 SPP1 TBP TXLNA UCHL5 ZHX1	50 interactors: AKR1C3 AKT1 ATXN1 BARD1 BCL2L1 BHLHE40 BID CHD3 CREB1 CSNK2A1 DDX39B DLST DYNLL1 EFNA2 ELL GADD45A GNG11 GSK3B HSPE1 IDH1 LAMA4 LYAR MPHOSPH6 NACA NFYA PAFAH1B3 PEX14 PIAS4 PIGC PNP PRPF40A PSMD11 SAT1 SERPINB9 SUMO2 TAL1 TALDO1 TARDBP TERF1 TNFRSF10C TOLLIP TP53 UTP3 VIM WDR33 ZHX2 ZHX3 ZMYND11 ZNF33B ZYX
Entrez ID		4666	11244
HPRD ID		03137	10379
Ensembl ID		ENSG00000196531	ENSG00000165156
Uniprot IDs		B2R4P8 Q13765	Q9UKY1
PDB IDs		3LKX 3MCB 3MCE	2ECB 2GHF 2LY9 3NAR
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Skeletal Muscle Cell Differentiation TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Myeloid Cell Differentiation Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Myeloid Leukocyte Differentiation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Nucleobase-containing Compound Metabolic Process Skeletal Muscle Tissue Development Cellular Macromolecule Biosynthetic Process Activation Of Innate Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Defense Response Macromolecule Biosynthetic Process Skeletal Muscle Organ Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Response To Organic Cyclic Compound Response To Extracellular Stimulus Immune Response-regulating Signaling Pathway Immune System Process Regulation Of Myeloid Cell Differentiation Organ Development Response To Toxic Substance Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Innate Immune Response Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Response To Reactive Oxygen Species Apoptotic Process Programmed Cell Death Cellular Response To Extracellular Stimulus Response To Mechanical Stimulus	Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Viral Process Regulation Of Mitochondrion Organization Negative Regulation Of Biosynthetic Process Apoptotic Process RNA Metabolic Process Programmed Cell Death Cell Death Death Cellular Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Transcription, DNA-templated Negative Regulation Of Gene Expression Cell Cycle Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Rhythmic Process Negative Regulation Of Cell Cycle Developmental Process Positive Regulation Of Protein Metabolic Process Biosynthetic Process Positive Regulation Of Protein Catabolic Process Cell Cycle Process Regulation Of Cell Cycle Process Regulation Of Proteolysis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Cellular Process Negative Regulation Of Transcription, DNA-templated
Tagcloud ?		ap apd20 apd50 apd90 atrial caf cal calibrate calibrated determines deviating electrophysiology explaining hampering inter ionic ito k1 kur mimic nak recordings rhythm sr trabeculae triangulation underlies variability yielding	199a 3p accumulating bound carcinogenesis direct dramatically epigenetic fingers gastric gc homeoboxes inversely involve micrornas mir mirnas n87 nci oncogenic regulator regulators restoring sgc suppressed untranslated upregulated utr zinc
Tagcloud (Difference) ?		ap apd20 apd50 apd90 atrial caf cal calibrate calibrated determines deviating electrophysiology explaining hampering inter ionic ito k1 kur mimic nak recordings rhythm sr trabeculae triangulation underlies variability yielding	199a 3p accumulating bound carcinogenesis direct dramatically epigenetic fingers gastric gc homeoboxes inversely involve micrornas mir mirnas n87 nci oncogenic regulator regulators restoring sgc suppressed untranslated upregulated utr zinc
Tagcloud (Intersection) ?