FRS3 and PLB1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FRS3	PLB1
Description		fibroblast growth factor receptor substrate 3	phospholipase B1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Fibroblast Growth Factor Receptor Binding Protein Binding Identical Protein Binding	Phospholipase Activity Phosphatidylcholine Lysophospholipase Activity Phospholipase A2 Activity Triacylglycerol Lipase Activity Protein Binding Lipase Activity Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds Calcium-independent Phospholipase A2 Activity Retinyl-palmitate Esterase Activity
	Biological Process	Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway	Retinoid Metabolic Process Lipid Metabolic Process Phospholipid Metabolic Process Triglyceride Catabolic Process Phosphatidylglycerol Catabolic Process Phosphatidylcholine Catabolic Process Phosphatidylcholine Acyl-chain Remodeling Retinol Metabolic Process Phosphatidylethanolamine Catabolic Process Diacylglycerol Catabolic Process Positive Regulation Of Acrosome Reaction
Pathways		FRS-mediated FGFR1 signaling FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling RAF/MAP kinase cascade Activated NTRK2 signals through FRS2 and FRS3 RND2 GTPase cycle RND1 GTPase cycle Signaling by ALK fusions and activated point mutants	Acyl chain remodelling of PC Retinoid metabolism and transport
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Cataracts ( 34127677) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Excessive sweating ( 29895819) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Intracranial aneurysm ( 29531279) Neutrophil percentage of granulocytes ( 27863252) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Sum eosinophil basophil counts ( 27863252) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		112 interacting genes: ACTMAP ADAMTSL4 ANAPC11 ANKRD55 ATP23 BLZF1 BMPR2 C22orf39 CATSPER1 CBY2 CCDC33 CCN3 CDPF1 CFAP68 COL8A1 COPS3 CREB5 CYSRT1 DCDC2B DDX5 DMRT3 DPEP2NB ECM1 ESM1 FGFR1 GATA1 GPRIN2 GRB14 GRB2 HOXA1 HOXD12 ID2 ID3 IKZF3 INCA1 ISY1-RAB43 KARS1 KATNBL1 KCNJ5-AS1 KIAA0408 KPRP KRT31 KRT33B KRT34 KRT35 KRT76 KRTAP1-1 KRTAP10-8 KRTAP11-1 KRTAP3-1 KRTAP3-2 KRTAP6-2 LINGO1 LRRC18 MAPK1 MATK MBD3L1 MIIP NADSYN1 NBPF19 NOTCH2NLA NTRK1 NTRK2 NUMB PCSK5 PDLIM7 PIH1D2 PLB1 PLLP PLSCR1 POF1B PRDM6 PRKCI PTPN11 RFX6 RIMBP3C RND1 SAXO4 SCNM1 SH2B1 SHANK3 SLAIN1 SLC67A1-AS SOCS6 SPATA12 SPRY2 STH STK16 TCF4 TCP10L TGM7 TLE5 TNS1 TRAF4 TRIP6 TSC1 TSGA10IP TSPAN4 UNKL VASP VGLL3 WDR83 WWOX YPEL3 ZMIZ2 ZNF124 ZNF417 ZNF438 ZNF446 ZNF552 ZNF69 ZSCAN30	8 interacting genes: FRS3 HSF2BP NLGN3 PIK3R3 RIN3 S100A1 TNS2 TSEN15
Entrez ID		10817	151056
HPRD ID		06373	15141
Ensembl ID		ENSG00000137218	ENSG00000163803
Uniprot IDs		A0A140VJJ7 O43559	B2RWP8 Q6P1J6
PDB IDs		2KUP 2KUQ 2YS5 2YT2
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Protein Binding Outer Ear Morphogenesis Structural Constituent Of Skin Epidermis Regulation Of Transcription By RNA Polymerase II Regulation Of Ossification Cellular Developmental Process Anatomical Structure Morphogenesis Structural Molecule Activity Intermediate Filament Organization Developmental Process Anatomical Structure Formation Involved In Morphogenesis Response To Growth Factor Neurotrophin Receptor Activity Neurotrophin Binding Negative Regulation Of Chondrocyte Proliferation Myelination Intermediate Filament Cytoskeleton Organization Supramolecular Fiber Organization Intermediate Filament-based Process Cell Differentiation Axon Ensheathment Cellular Response To Growth Factor Stimulus
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