FRS3 and TNS1

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		FRS3	TNS1
Description		fibroblast growth factor receptor substrate 3	tensin 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Cytoplasm Cytoskeleton Focal Adhesion Cell Surface Cell-substrate Junction Anchoring Junction
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Fibroblast Growth Factor Receptor Binding Protein Binding Identical Protein Binding	RNA Binding Actin Binding Phosphoprotein Phosphatase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway	Cell-substrate Junction Assembly Fibroblast Migration
Pathways		FRS-mediated FGFR1 signaling FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling RAF/MAP kinase cascade Activated NTRK2 signals through FRS2 and FRS3 RND2 GTPase cycle RND1 GTPase cycle Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870)	Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Asthma and hay fever ( 24388013) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease ( 33909500 30804561) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Coronary artery disease ( 33020668 29212778) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878 28135244) Diverticular disease ( 30177863) FEV1 ( 30804560) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels in HIV infection ( 33109212) Height ( 20881960 28552196 25429064 25282103 21998595) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Intraocular pressure ( 30054594 29785010 29617998 29235454) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560 28166213) Lung function (FVC) ( 30804560 28166213) Lung function (low FEV1 vs high FEV1) ( 26423011) Mitral valve prolapse ( 26301497) Myocardial infarction ( 33532862) Pulmonary function ( 20010834) Pulmonary function (smoking interaction) ( 23284291) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		112 interacting genes: ACTMAP ADAMTSL4 ANAPC11 ANKRD55 ATP23 BLZF1 BMPR2 C22orf39 CATSPER1 CBY2 CCDC33 CCN3 CDPF1 CFAP68 COL8A1 COPS3 CREB5 CYSRT1 DCDC2B DDX5 DMRT3 DPEP2NB ECM1 ESM1 FGFR1 GATA1 GPRIN2 GRB14 GRB2 HOXA1 HOXD12 ID2 ID3 IKZF3 INCA1 ISY1-RAB43 KARS1 KATNBL1 KCNJ5-AS1 KIAA0408 KPRP KRT31 KRT33B KRT34 KRT35 KRT76 KRTAP1-1 KRTAP10-8 KRTAP11-1 KRTAP3-1 KRTAP3-2 KRTAP6-2 LINGO1 LRRC18 MAPK1 MATK MBD3L1 MIIP NADSYN1 NBPF19 NOTCH2NLA NTRK1 NTRK2 NUMB PCSK5 PDLIM7 PIH1D2 PLB1 PLLP PLSCR1 POF1B PRDM6 PRKCI PTPN11 RFX6 RIMBP3C RND1 SAXO4 SCNM1 SH2B1 SHANK3 SLAIN1 SLC67A1-AS SOCS6 SPATA12 SPRY2 STH STK16 TCF4 TCP10L TGM7 TLE5 TNS1 TRAF4 TRIP6 TSC1 TSGA10IP TSPAN4 UNKL VASP VGLL3 WDR83 WWOX YPEL3 ZMIZ2 ZNF124 ZNF417 ZNF438 ZNF446 ZNF552 ZNF69 ZSCAN30	16 interacting genes: AR CAPN2 EGFR ERBB2 ERBB3 ERBB4 FRS3 GAB1 KIT KLF10 MET OSGEP PPP1CC PTK2 RNF10 YWHAZ
Entrez ID		10817	7145
HPRD ID		06373	02512
Ensembl ID		ENSG00000137218	ENSG00000079308
Uniprot IDs		A0A140VJJ7 O43559	A0A2R8Y4T1 A1L0S7 B2RU35 B7Z6H8 E9PF55 E9PGF5 Q0VG54 Q0VG55 Q59G71 Q86VB0 Q9HBL0
PDB IDs		2KUP 2KUQ 2YS5 2YT2
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Protein Binding Outer Ear Morphogenesis Structural Constituent Of Skin Epidermis Regulation Of Transcription By RNA Polymerase II Regulation Of Ossification Cellular Developmental Process Anatomical Structure Morphogenesis Structural Molecule Activity Intermediate Filament Organization Developmental Process Anatomical Structure Formation Involved In Morphogenesis Response To Growth Factor Neurotrophin Receptor Activity Neurotrophin Binding Negative Regulation Of Chondrocyte Proliferation Myelination Intermediate Filament Cytoskeleton Organization Supramolecular Fiber Organization Intermediate Filament-based Process Cell Differentiation Axon Ensheathment Cellular Response To Growth Factor Stimulus	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Developmental Process Basal Plasma Membrane ERBB2 Signaling Pathway Receptor Complex Protein Phosphatase Binding Negative Regulation Of Programmed Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Programmed Cell Death Protein Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphate Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Neuron Differentiation Regulation Of Multicellular Organismal Process Positive Regulation Of Developmental Process Kinase Activity Positive Regulation Of Epithelial Cell Proliferation ERBB3:ERBB2 Complex Regulation Of MAPK Cascade Animal Organ Development Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Signal Transduction Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Apoptotic Process Transferase Activity Regulation Of Phosphorus Metabolic Process Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Growth Factor Binding Cellular Response To Epidermal Growth Factor Stimulus Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Regulation Of Apoptotic Process Regulation Of Epithelial Cell Proliferation
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