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FRS3 and PRKCI
Number of citations of the paper that reports this interaction (PubMedID
10383403
)
0
Data Source:
HPRD
(two hybrid, in vitro)
FRS3
PRKCI
Description
fibroblast growth factor receptor substrate 3
protein kinase C iota
Image
GO Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Membrane
Golgi Membrane
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Brush Border
Bicellular Tight Junction
Cilium
Microtubule Cytoskeleton
Membrane
Apical Plasma Membrane
Cell Leading Edge
Schmidt-Lanterman Incisure
Intercellular Bridge
Apical Part Of Cell
Extracellular Exosome
Tight Junction
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
PAR Polarity Complex
Molecular Function
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Fibroblast Growth Factor Receptor Binding
Protein Binding
Identical Protein Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Diacylglycerol-dependent Serine/threonine Kinase Activity
Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Phospholipid Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
Signal Transduction
Fibroblast Growth Factor Receptor Signaling Pathway
Protein Phosphorylation
Protein Targeting To Membrane
Cytoskeleton Organization
Actin Filament Organization
Positive Regulation Of Neuron Projection Development
Vesicle-mediated Transport
Cell Migration
Establishment Of Cell Polarity
Cellular Response To Insulin Stimulus
Negative Regulation Of Glial Cell Apoptotic Process
Establishment Of Apical/basal Cell Polarity
Intracellular Signal Transduction
Eye Photoreceptor Cell Development
Negative Regulation Of Apoptotic Process
Response To Peptide Hormone
Negative Regulation Of Neuron Apoptotic Process
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Cell-cell Junction Organization
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of D-glucose Import
Secretion
Golgi Vesicle Budding
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Glial Cell Proliferation
Membrane Organization
Cellular Response To Chemical Stress
Response To Interleukin-1
Protein Localization To Plasma Membrane
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways
FRS-mediated FGFR1 signaling
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
RAF/MAP kinase cascade
Activated NTRK2 signals through FRS2 and FRS3
RND2 GTPase cycle
RND1 GTPase cycle
Signaling by ALK fusions and activated point mutants
Pre-NOTCH Transcription and Translation
p75NTR recruits signalling complexes
Tight junction interactions
KEAP1-NFE2L2 pathway
Drugs
Tamoxifen
Staurosporine
Bisindolylmaleimide I
Dequalinium
Benzoyl peroxide
Fostamatinib
Diseases
GWAS
Menarche (age at onset) (
25231870
)
Aspartate aminotransferase levels (
33547301
)
Microalbuminuria (
31511532
)
Prostate cancer (
25939597
)
Urinary albumin excretion (
30220432
)
Urinary albumin-to-creatinine ratio (
31511532
31630189
)
Interacting Genes
112 interacting genes:
ACTMAP
ADAMTSL4
ANAPC11
ANKRD55
ATP23
BLZF1
BMPR2
C22orf39
CATSPER1
CBY2
CCDC33
CCN3
CDPF1
CFAP68
COL8A1
COPS3
CREB5
CYSRT1
DCDC2B
DDX5
DMRT3
DPEP2NB
ECM1
ESM1
FGFR1
GATA1
GPRIN2
GRB14
GRB2
HOXA1
HOXD12
ID2
ID3
IKZF3
INCA1
ISY1-RAB43
KARS1
KATNBL1
KCNJ5-AS1
KIAA0408
KPRP
KRT31
KRT33B
KRT34
KRT35
KRT76
KRTAP1-1
KRTAP10-8
KRTAP11-1
KRTAP3-1
KRTAP3-2
KRTAP6-2
LINGO1
LRRC18
MAPK1
MATK
MBD3L1
MIIP
NADSYN1
NBPF19
NOTCH2NLA
NTRK1
NTRK2
NUMB
PCSK5
PDLIM7
PIH1D2
PLB1
PLLP
PLSCR1
POF1B
PRDM6
PRKCI
PTPN11
RFX6
RIMBP3C
RND1
SAXO4
SCNM1
SH2B1
SHANK3
SLAIN1
SLC67A1-AS
SOCS6
SPATA12
SPRY2
STH
STK16
TCF4
TCP10L
TGM7
TLE5
TNS1
TRAF4
TRIP6
TSC1
TSGA10IP
TSPAN4
UNKL
VASP
VGLL3
WDR83
WWOX
YPEL3
ZMIZ2
ZNF124
ZNF417
ZNF438
ZNF446
ZNF552
ZNF69
ZSCAN30
51 interacting genes:
ADAP1
ANXA1
APP
BAD
CASK
CASP8
CCNT1
CDC42
CDK7
CHUK
CTBP1
FABP4
FCGR3A
FRS2
FRS3
GAPDH
HRAS
IKBKG
IL1RAP
IRAK1
MAP2K1
MAP2K5
MAPT
MARK4
MBP
MEOX2
NACC1
NFKBIA
PARD3
PARD6A
PARD6B
PARD6G
PCM1
PDPK1
PNMA1
RAB2A
RAB4A
RAC1
RBM14
RHOQ
SMG1
SMURF1
SQSTM1
SRC
TSC22D1
TTR
UBC
USP20
VHL
YWHAH
YWHAZ
Entrez ID
10817
5584
HPRD ID
06373
02105
Ensembl ID
ENSG00000137218
ENSG00000163558
Uniprot IDs
A0A140VJJ7
O43559
P41743
PDB IDs
2KUP
2KUQ
2YS5
2YT2
1VD2
1WMH
1ZRZ
3A8W
3A8X
3ZH8
5LI1
5LI9
5LIH
6ILZ
8R3X
8R3Y
Enriched GO Terms of Interacting Partners
?
Keratin Filament
Intermediate Filament
Protein Binding
Outer Ear Morphogenesis
Structural Constituent Of Skin Epidermis
Regulation Of Transcription By RNA Polymerase II
Regulation Of Ossification
Cellular Developmental Process
Anatomical Structure Morphogenesis
Structural Molecule Activity
Intermediate Filament Organization
Developmental Process
Anatomical Structure Formation Involved In Morphogenesis
Response To Growth Factor
Neurotrophin Receptor Activity
Neurotrophin Binding
Negative Regulation Of Chondrocyte Proliferation
Myelination
Intermediate Filament Cytoskeleton Organization
Supramolecular Fiber Organization
Intermediate Filament-based Process
Cell Differentiation
Axon Ensheathment
Cellular Response To Growth Factor Stimulus
Cytoplasm
Cytosol
Intracellular Signaling Cassette
Positive Regulation Of Metabolic Process
Cell Surface Receptor Signaling Pathway
Regulation Of Cellular Localization
Intracellular Signal Transduction
Immune System Process
PAR Polarity Complex
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Signal Transduction
Regulation Of Protein Localization
Positive Regulation Of Biosynthetic Process
Regulation Of Multicellular Organismal Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Immune System Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Response To Stress
Regulation Of Gene Expression
Positive Regulation Of Protein Localization
Regulation Of Immune Response
Plasma Membrane
Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cell Projection Organization
Regulation Of Programmed Cell Death
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Regulation Of Organelle Organization
Negative Regulation Of Programmed Cell Death
Protein Serine/threonine Kinase Activity
Regulation Of Signaling
Regulation Of Cell Communication
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Regulation Of Immune System Process
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Regulation Of Apoptotic Process
Establishment Or Maintenance Of Cell Polarity
Establishment Or Maintenance Of Apical/basal Cell Polarity
Regulation Of Cell Projection Organization
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Cytokine Production
Regulation Of Primary Metabolic Process
Regulation Of Innate Immune Response
Immune Response-activating Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Intracellular Signal Transduction
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Tagcloud (Intersection)
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