FRS3 and KARS

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		FRS3	KARS
Gene Name		fibroblast growth factor receptor substrate 3	lysyl-tRNA synthetase
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane	Extracellular Region Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Microtubule Cytoskeleton Aminoacyl-tRNA Synthetase Multienzyme Complex
	Molecular Function	Fibroblast Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding	TRNA Binding Lysine-tRNA Ligase Activity Protein Binding ATP Binding Amino Acid Binding Metal Ion Binding
	Biological Process	Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway	TRNA Aminoacylation For Protein Translation Lysyl-tRNA Aminoacylation TRNA Processing Gene Expression Diadenosine Tetraphosphate Biosynthetic Process Viral Process
Pathways		Signaling by FGFR in disease FRS2-mediated cascade Downstream signaling of activated FGFR Signaling by FGFR	Cytosolic tRNA aminoacylation tRNA Aminoacylation Mitochondrial tRNA aminoacylation
Drugs			L-Lysine
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ADAMTSL4 AES BMPR2 FGFR1 GATA1 GRB2 KARS MAPK1 NOTCH2NL NTRK1 NTRK2 PLSCR1 PRKCI PTPN11 RFX6 RND1 SPERT SPRY2 TCF4 TRIP6	15 interactors: AIMP2 DARS2 EEF1D EEF1G FRS3 GAPDH GEMIN4 MAPK1 MAPK14 PAFAH1B1 PIK3R3 RPSA SLC25A6 SOD1 VIM
Entrez ID		10817	3735
HPRD ID		06373	03249
Ensembl ID		ENSG00000137218	ENSG00000065427
Uniprot IDs		O43559	Q15046
PDB IDs		2KUP 2KUQ 2YS5 2YT2	3BJU 4DPG
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Signaling Cellular Response To Growth Factor Stimulus Response To Growth Factor Cell Differentiation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Cell Development Response To External Stimulus Organ Development Positive Regulation Of Protein Phosphorylation Response To Organic Substance Multicellular Organismal Development Positive Regulation Of Cellular Metabolic Process Generation Of Neurons Positive Regulation Of Intracellular Signal Transduction System Development Positive Regulation Of Neuron Differentiation Neurogenesis Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Protein Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of MAPK Cascade Response To Fibroblast Growth Factor Neuron Development Developmental Process Intracellular Signal Transduction Axon Guidance Organ Morphogenesis Positive Regulation Of Neurogenesis Cell Surface Receptor Signaling Pathway Signaling Cellular Response To Insulin Stimulus Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Neuron Projection Development Cell Communication Regulation Of Protein Phosphorylation Cell Morphogenesis Involved In Differentiation Epithelium Development	Apoptotic Process Retrograde Axon Cargo Transport Programmed Cell Death Cell Death Death Small Molecule Metabolic Process Translation Activation Of MAPK Activity Biosynthetic Process Translational Elongation Enzyme Linked Receptor Protein Signaling Pathway NcRNA Metabolic Process Platelet Activation Organelle Organization Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of MAP Kinase Activity Viral Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Osteoclast Differentiation Cellular Protein Metabolic Process Gliogenesis Gene Expression Axon Cargo Transport Regulation Of MAPK Cascade Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Transmission Of Nerve Impulse Cellular Metabolic Process Cellular Response To Organic Substance Activation Of Protein Kinase Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Mitochondrial Asparaginyl-tRNA Aminoacylation Response To Antipsychotic Drug Peptidyl-cysteine S-trans-nitrosylation P38MAPK Cascade TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Response To Other Organism Toll-like Receptor 3 Signaling Pathway Regulation Of Phosphorylation MyD88-dependent Toll-like Receptor Signaling Pathway Cell Aging
Tagcloud ?		2yf 4yf adapters alleviated anophthalmia coordinated ectodermal embryogenesis eye fgf fgfr laevis maternally microphthalmia mo morphants morpholino oligonucleotide pax6 pi3 placode rescue served shp2 vertebrate xenopus xfrs3 zygotically	aars acylating aminoacyl aminoars aminoarss bodies canonical dorsal drg functions ganglia glutaminyl horn injured lysyl nerve pharmaceutical possibility powerful primers qars root satellite sensory spinal synthetase synthetases trna typical
Tagcloud (Difference) ?		2yf 4yf adapters alleviated anophthalmia coordinated ectodermal embryogenesis eye fgf fgfr laevis maternally microphthalmia mo morphants morpholino oligonucleotide pax6 pi3 placode rescue served shp2 vertebrate xenopus xfrs3 zygotically	aars acylating aminoacyl aminoars aminoarss bodies canonical dorsal drg functions ganglia glutaminyl horn injured lysyl nerve pharmaceutical possibility powerful primers qars root satellite sensory spinal synthetase synthetases trna typical
Tagcloud (Intersection) ?