FRS3 and ZNF69

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FRS3	ZNF69
Description		fibroblast growth factor receptor substrate 3	zinc finger protein 69
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Nucleus
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Fibroblast Growth Factor Receptor Binding Protein Binding Identical Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		FRS-mediated FGFR1 signaling FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling RAF/MAP kinase cascade Activated NTRK2 signals through FRS2 and FRS3 RND2 GTPase cycle RND1 GTPase cycle Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870)	Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		112 interacting genes: ACTMAP ADAMTSL4 ANAPC11 ANKRD55 ATP23 BLZF1 BMPR2 C22orf39 CATSPER1 CBY2 CCDC33 CCN3 CDPF1 CFAP68 COL8A1 COPS3 CREB5 CYSRT1 DCDC2B DDX5 DMRT3 DPEP2NB ECM1 ESM1 FGFR1 GATA1 GPRIN2 GRB14 GRB2 HOXA1 HOXD12 ID2 ID3 IKZF3 INCA1 ISY1-RAB43 KARS1 KATNBL1 KCNJ5-AS1 KIAA0408 KPRP KRT31 KRT33B KRT34 KRT35 KRT76 KRTAP1-1 KRTAP10-8 KRTAP11-1 KRTAP3-1 KRTAP3-2 KRTAP6-2 LINGO1 LRRC18 MAPK1 MATK MBD3L1 MIIP NADSYN1 NBPF19 NOTCH2NLA NTRK1 NTRK2 NUMB PCSK5 PDLIM7 PIH1D2 PLB1 PLLP PLSCR1 POF1B PRDM6 PRKCI PTPN11 RFX6 RIMBP3C RND1 SAXO4 SCNM1 SH2B1 SHANK3 SLAIN1 SLC67A1-AS SOCS6 SPATA12 SPRY2 STH STK16 TCF4 TCP10L TGM7 TLE5 TNS1 TRAF4 TRIP6 TSC1 TSGA10IP TSPAN4 UNKL VASP VGLL3 WDR83 WWOX YPEL3 ZMIZ2 ZNF124 ZNF417 ZNF438 ZNF446 ZNF552 ZNF69 ZSCAN30	12 interacting genes: CFTR FAM124B FRS3 GTPBP3 KATNAL1 KRT31 LMNA LMO3 MEOX2 P4HB SMARCD1 ZNF417
Entrez ID		10817	7620
HPRD ID		06373	11836
Ensembl ID		ENSG00000137218	ENSG00000198429
Uniprot IDs		A0A140VJJ7 O43559	Q9UC07
PDB IDs		2KUP 2KUQ 2YS5 2YT2
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Protein Binding Outer Ear Morphogenesis Structural Constituent Of Skin Epidermis Regulation Of Transcription By RNA Polymerase II Regulation Of Ossification Cellular Developmental Process Anatomical Structure Morphogenesis Structural Molecule Activity Intermediate Filament Organization Developmental Process Anatomical Structure Formation Involved In Morphogenesis Response To Growth Factor Neurotrophin Receptor Activity Neurotrophin Binding Negative Regulation Of Chondrocyte Proliferation Myelination Intermediate Filament Cytoskeleton Organization Supramolecular Fiber Organization Intermediate Filament-based Process Cell Differentiation Axon Ensheathment Cellular Response To Growth Factor Stimulus	NBAF Complex RSC-type Complex NpBAF Complex GBAF Complex Nuclear Matrix Nucleosome Disassembly Protein-DNA Complex Disassembly Isomerase Activity Regulation Of Nucleotide-excision Repair SWI/SNF Complex Regulation Of G0 To G1 Transition Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Chromosome Organization Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Stem Cell Population Maintenance Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Myoblast Differentiation Positive Regulation Of Anion Channel Activity DNA Double-strand Break Attachment To Nuclear Envelope Epigenetic Regulation Of Gene Expression Structural Constituent Of Nuclear Lamina Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Procollagen-proline 4-dioxygenase Complex Regulation Of Stem Cell Population Maintenance Transcription Coactivator Activity Regulation Of Myoblast Differentiation Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway TRNA 5-taurinomethyluridine Synthase Activity Mitochondrial TRNA Wobble Uridine Modification Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of Mitotic Metaphase/anaphase Transition ATP Hydrolysis Activity Positive Regulation Of Double-strand Break Repair Structural Constituent Of Cytoskeleton Positive Regulation Of Enamel Mineralization Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Peptidyl-proline Hydroxylation Regulation Of Sister Chromatid Segregation Regulation Of Glucose Mediated Signaling Pathway Transepithelial Water Transport Lamin Filament Nuclear Pore Localization Somite Specification Procollagen-proline 4-dioxygenase Activity Nucleosome Array Spacer Activity Positive Regulation Of T Cell Differentiation
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