FRS3 and NTRK2

Number of citations of the paper that reports this interaction (PMID 11432792)
3

Data Source:
HPRD (in vitro)

		FRS3	NTRK2
Gene Name		fibroblast growth factor receptor substrate 3	neurotrophic tyrosine kinase, receptor, type 2
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane	Rough Endoplasmic Reticulum Cytosol Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Growth Cone Terminal Bouton Dendritic Spine Perikaryon Receptor Complex Postsynaptic Membrane Presynaptic Active Zone Excitatory Synapse Neuronal Postsynaptic Density
	Molecular Function	Fibroblast Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding	ATP Binding Protein Homodimerization Activity Neurotrophin Binding Ephrin Receptor Binding Brain-derived Neurotrophic Factor Binding Brain-derived Neurotrophic Factor-activated Receptor Activity
	Biological Process	Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway	Vasculogenesis Neuron Migration Inflammatory Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Adenylate Cyclase Activity Neuromuscular Junction Development Aging Learning Long-term Memory Circadian Rhythm Feeding Behavior Positive Regulation Of Cell Proliferation Response To Light Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Glutamate Secretion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Central Nervous System Neuron Development Cerebral Cortex Development Neuron Differentiation Brain-derived Neurotrophic Factor Receptor Signaling Pathway Regulation Of Rac GTPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source Mechanoreceptor Differentiation Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Retinal Rod Cell Development Protein Autophosphorylation Regulation Of Neurotransmitter Secretion Neurotrophin TRK Receptor Signaling Pathway Oligodendrocyte Differentiation Peripheral Nervous System Neuron Development Positive Regulation Of Axonogenesis Regulation Of Dendrite Development Regulation Of Protein Kinase B Signaling Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Cellular Response To Tumor Necrosis Factor Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Anoikis
Pathways		Signaling by FGFR in disease FRS2-mediated cascade Downstream signaling of activated FGFR Signaling by FGFR	Signalling by NGF Activation of TRKA receptors NGF-independant TRKA activation NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS			Waist-to-hip circumference ratio (interaction) ( 23192594)
Protein-Protein Interactions		20 interactors: ADAMTSL4 AES BMPR2 FGFR1 GATA1 GRB2 KARS MAPK1 NOTCH2NL NTRK1 NTRK2 PLSCR1 PRKCI PTPN11 RFX6 RND1 SPERT SPRY2 TCF4 TRIP6	29 interactors: AP1B1 BDNF DOK5 DYNLL1 FRS2 FRS3 FYN GIPC1 KIDINS220 NCK1 NCK2 NGFR NMNAT1 NTF3 NTF4 PIK3R1 PLCG1 POLR2G PTPN1 PTPN11 RASGRF1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SQSTM1 TRAF6 UBB
Entrez ID		10817	4915
HPRD ID		06373	02712
Ensembl ID		ENSG00000137218	ENSG00000148053
Uniprot IDs		O43559	Q16620 Q548C2 Q5VWE5
PDB IDs		2KUP 2KUQ 2YS5 2YT2	1HCF 1WWB 4ASZ 4AT3 4AT4 4AT5
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Signaling Cellular Response To Growth Factor Stimulus Response To Growth Factor Cell Differentiation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Cell Development Response To External Stimulus Organ Development Positive Regulation Of Protein Phosphorylation Response To Organic Substance Multicellular Organismal Development Positive Regulation Of Cellular Metabolic Process Generation Of Neurons Positive Regulation Of Intracellular Signal Transduction System Development Positive Regulation Of Neuron Differentiation Neurogenesis Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Protein Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of MAPK Cascade Response To Fibroblast Growth Factor Neuron Development Developmental Process Intracellular Signal Transduction Axon Guidance Organ Morphogenesis Positive Regulation Of Neurogenesis Cell Surface Receptor Signaling Pathway Signaling Cellular Response To Insulin Stimulus Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Neuron Projection Development Cell Communication Regulation Of Protein Phosphorylation Cell Morphogenesis Involved In Differentiation Epithelium Development	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Regulation Of Phosphorylation Cellular Response To Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Protein Phosphorylation Nervous System Development Insulin Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Kinase Activity Activation Of Protein Kinase Activity Fc Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Intracellular Signal Transduction Response To Stimulus Cellular Response To Peptide Hormone Stimulus Neuron Projection Development Cellular Response To Peptide Cellular Response To Organonitrogen Compound Neuron Projection Morphogenesis Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Cellular Response To Insulin Stimulus Positive Regulation Of Cellular Protein Metabolic Process Cell Projection Organization Fc-epsilon Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Activation Of MAPK Activity Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Protein Phosphorylation Response To Organic Substance
Tagcloud ?		2yf 4yf adapters alleviated anophthalmia coordinated ectodermal embryogenesis eye fgf fgfr laevis maternally microphthalmia mo morphants morpholino oligonucleotide pax6 pi3 placode rescue served shp2 vertebrate xenopus xfrs3 zygotically	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?		2yf 4yf adapters alleviated anophthalmia coordinated ectodermal embryogenesis eye fgf fgfr laevis maternally microphthalmia mo morphants morpholino oligonucleotide pax6 pi3 placode rescue served shp2 vertebrate xenopus xfrs3 zygotically	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?