FRS3 and SOCS6

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		FRS3	SOCS6
Description		fibroblast growth factor receptor substrate 3	suppressor of cytokine signaling 6
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Immunological Synapse Cytoplasm Cytosol
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Fibroblast Growth Factor Receptor Binding Protein Binding Identical Protein Binding	Protein Binding Signaling Adaptor Activity
	Biological Process	Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway	Defense Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Regulation Of Growth Negative Regulation Of T Cell Activation
Pathways		FRS-mediated FGFR1 signaling FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling RAF/MAP kinase cascade Activated NTRK2 signals through FRS2 and FRS3 RND2 GTPase cycle RND1 GTPase cycle Signaling by ALK fusions and activated point mutants	Regulation of KIT signaling Neddylation Negative regulation of FLT3
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870)	Diverticular disease ( 30177863) Night sleep phenotypes ( 27126917) Systemic lupus erythematosus ( 18204098) Type 2 diabetes ( 29621232)
Interacting Genes		112 interacting genes: ACTMAP ADAMTSL4 ANAPC11 ANKRD55 ATP23 BLZF1 BMPR2 C22orf39 CATSPER1 CBY2 CCDC33 CCN3 CDPF1 CFAP68 COL8A1 COPS3 CREB5 CYSRT1 DCDC2B DDX5 DMRT3 DPEP2NB ECM1 ESM1 FGFR1 GATA1 GPRIN2 GRB14 GRB2 HOXA1 HOXD12 ID2 ID3 IKZF3 INCA1 ISY1-RAB43 KARS1 KATNBL1 KCNJ5-AS1 KIAA0408 KPRP KRT31 KRT33B KRT34 KRT35 KRT76 KRTAP1-1 KRTAP10-8 KRTAP11-1 KRTAP3-1 KRTAP3-2 KRTAP6-2 LINGO1 LRRC18 MAPK1 MATK MBD3L1 MIIP NADSYN1 NBPF19 NOTCH2NLA NTRK1 NTRK2 NUMB PCSK5 PDLIM7 PIH1D2 PLB1 PLLP PLSCR1 POF1B PRDM6 PRKCI PTPN11 RFX6 RIMBP3C RND1 SAXO4 SCNM1 SH2B1 SHANK3 SLAIN1 SLC67A1-AS SOCS6 SPATA12 SPRY2 STH STK16 TCF4 TCP10L TGM7 TLE5 TNS1 TRAF4 TRIP6 TSC1 TSGA10IP TSPAN4 UNKL VASP VGLL3 WDR83 WWOX YPEL3 ZMIZ2 ZNF124 ZNF417 ZNF438 ZNF446 ZNF552 ZNF69 ZSCAN30	38 interacting genes: ACVR1 AIRIM AMOT APPL1 AR BMPR1B CLNK CRK DAB1 EFEMP1 EGFR ELOB ELOC ERBB2 ERBB3 ERBB4 FRS3 GAB1 INSR IRS2 IRS4 KDM1A KIT LNX1 MET PIK3R1 PIK3R2 RBCK1 RELA SMURF2 TGFBR1 TUBA1A TUBB4B TXK UBE2D2 UBE2I WDR89 ZMIZ2
Entrez ID		10817	9306
HPRD ID		06373	05491
Ensembl ID		ENSG00000137218	ENSG00000170677
Uniprot IDs		A0A140VJJ7 O43559	O14544
PDB IDs		2KUP 2KUQ 2YS5 2YT2	2VIF
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Protein Binding Outer Ear Morphogenesis Structural Constituent Of Skin Epidermis Regulation Of Transcription By RNA Polymerase II Regulation Of Ossification Cellular Developmental Process Anatomical Structure Morphogenesis Structural Molecule Activity Intermediate Filament Organization Developmental Process Anatomical Structure Formation Involved In Morphogenesis Response To Growth Factor Neurotrophin Receptor Activity Neurotrophin Binding Negative Regulation Of Chondrocyte Proliferation Myelination Intermediate Filament Cytoskeleton Organization Supramolecular Fiber Organization Intermediate Filament-based Process Cell Differentiation Axon Ensheathment Cellular Response To Growth Factor Stimulus	Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Cell Migration Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Locomotion Cellular Response To Growth Factor Stimulus Receptor Complex Protein Tyrosine Kinase Activity Insulin Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Response To Growth Factor Positive Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Regulation Of Locomotion Negative Regulation Of Programmed Cell Death Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Activity Epidermal Growth Factor Receptor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Phosphatidylinositol 3-kinase Binding Growth Factor Binding Regulation Of Gene Expression Kinase Activity Regulation Of RNA Metabolic Process Transforming Growth Factor Beta Receptor Activity, Type I ErbB-3 Class Receptor Binding Positive Regulation Of Metabolic Process Protein Modification Process ERBB2 Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription
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