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XPA and MSH3
Number of citations of the paper that reports this interaction (PMID
19468048
)
25
Data Source:
BioGRID
(pull down)
XPA
MSH3
Gene Name
xeroderma pigmentosum, complementation group A
mutS homolog 3
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Cytoplasm
Golgi Apparatus
Intercellular Bridge
Nuclear Chromosome
Nucleus
Nucleoplasm
Membrane
MutSbeta Complex
Molecular Function
Damaged DNA Binding
Protein Binding
Protein Domain Specific Binding
Protein Homodimerization Activity
Metal Ion Binding
Y-form DNA Binding
Heteroduplex DNA Loop Binding
Double-strand/single-strand DNA Junction Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
DNA-dependent ATPase Activity
Centromeric DNA Binding
Enzyme Binding
Mismatched DNA Binding
Guanine/thymine Mispair Binding
Dinucleotide Insertion Or Deletion Binding
Single Guanine Insertion Binding
Dinucleotide Repeat Insertion Binding
Oxidized Purine DNA Binding
Protein Homodimerization Activity
Biological Process
Nucleotide-excision Repair, DNA Damage Removal
DNA Repair
Nucleotide-excision Repair
Response To Oxidative Stress
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To UV
Response To Toxic Substance
Multicellular Organism Growth
Meiotic Mismatch Repair
DNA Repair
Mismatch Repair
Reciprocal Meiotic Recombination
Somatic Recombination Of Immunoglobulin Gene Segments
Maintenance Of DNA Repeat Elements
Negative Regulation Of DNA Recombination
Positive Regulation Of Helicase Activity
Pathways
Nucleotide Excision Repair
Global Genomic NER (GG-NER)
Formation of incision complex in GG-NER
Dual incision reaction in GG-NER
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch Repair
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Thyroid cancer (Papillary, radiation-related) (
20350937
)
Protein-Protein Interactions
20 interactors:
ATM
ATR
DDB1
DDB2
ERCC1
ERCC6
GPN1
GTF2E2
GTF2H1
HERC2
MSH2
MSH3
NDEL1
PRKDC
RASSF1
RPA1
RPA2
RPA4
TRIM27
XAB2
12 interactors:
BARD1
BRCA1
EXO1
HUS1
MLH1
MSH2
PCNA
RAD1
RAD9A
RCHY1
RPA4
XPA
Entrez ID
7507
4437
HPRD ID
02045
02931
Ensembl ID
ENSG00000136936
ENSG00000113318
Uniprot IDs
P23025
A1L480
P20585
PDB IDs
1D4U
1XPA
2JNW
3THW
3THX
3THY
3THZ
Enriched GO Terms of Interacting Partners
?
DNA Repair
Cellular Response To DNA Damage Stimulus
Nucleotide-excision Repair
DNA Metabolic Process
Cellular Response To Stress
Nucleotide-excision Repair, DNA Damage Removal
DNA Recombination
Transcription-coupled Nucleotide-excision Repair
Response To Stress
Double-strand Break Repair
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Response To UV
Cellular Aromatic Compound Metabolic Process
Response To Ionizing Radiation
Response To Radiation
DNA Catabolic Process
DNA Damage Checkpoint
Cellular Nitrogen Compound Metabolic Process
Cell Cycle Process
Response To Abiotic Stimulus
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Nitrogen Compound Metabolic Process
Regulation Of Cellular Response To Heat
Somatic Recombination Of Immunoglobulin Gene Segments
Somatic Diversification Of Immunoglobulins
Cell Cycle Checkpoint
Cell Cycle
Chromosome Organization
Aromatic Compound Catabolic Process
Pyrimidine Dimer Repair
Response To Gamma Radiation
Mismatch Repair
Cellular Response To Stimulus
Immunoglobulin Production
Cellular Macromolecule Catabolic Process
Response To Light Stimulus
Cellular Response To Heat
Telomere Maintenance
Mitotic Cell Cycle Process
Reproduction
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Mitotic DNA Damage Checkpoint
Organelle Organization
Negative Regulation Of DNA Metabolic Process
Mitotic DNA Integrity Checkpoint
Mitotic Cell Cycle
Response To X-ray
Mitotic Recombination
DNA Repair
Cellular Response To DNA Damage Stimulus
DNA Metabolic Process
Cellular Response To Stress
DNA Recombination
Cell Cycle
DNA Damage Checkpoint
Cell Cycle Process
Cell Cycle Checkpoint
DNA Replication
Response To Ionizing Radiation
Response To Stress
Mismatch Repair
Somatic Hypermutation Of Immunoglobulin Genes
Somatic Diversification Of Immune Receptors Via Somatic Mutation
Response To Radiation
Negative Regulation Of Cell Cycle
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Nucleobase-containing Compound Metabolic Process
Postreplication Repair
Isotype Switching
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Somatic Recombination Of Immunoglobulin Gene Segments
DNA Catabolic Process
DNA Catabolic Process, Exonucleolytic
Double-strand Break Repair
Somatic Diversification Of Immunoglobulins
Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response
Nitrogen Compound Metabolic Process
B Cell Activation Involved In Immune Response
Cellular Macromolecule Catabolic Process
Aromatic Compound Catabolic Process
Intrinsic Apoptotic Signaling Pathway
Regulation Of Cell Cycle
Meiotic Cell Cycle
Cellular Response To Ionizing Radiation
Immunoglobulin Production
Protein K6-linked Ubiquitination
Response To Abiotic Stimulus
Cellular Response To Stimulus
Intra-S DNA Damage Checkpoint
Mitotic Cell Cycle Process
Nucleotide-excision Repair
Negative Regulation Of DNA Metabolic Process
Apoptotic Signaling Pathway
Mitotic Cell Cycle
Response To UV
Cellular Metabolic Process
Tagcloud
?
addressed
aom
apc
apex1
azoxymethane
carcinogenesis
colorectal
crc
dextran
dss
epi
experimentally
expressions
mgmt
mismatch
mlh1
mlh3
mmr
pilot
pms1
pms2
precancerous
prerequisite
rectum
sacrificed
sequential
sigmoid
sulphate
suppressor
Tagcloud (Difference)
?
addressed
aom
apc
apex1
azoxymethane
carcinogenesis
colorectal
crc
dextran
dss
epi
experimentally
expressions
mgmt
mismatch
mlh1
mlh3
mmr
pilot
pms1
pms2
precancerous
prerequisite
rectum
sacrificed
sequential
sigmoid
sulphate
suppressor
Tagcloud (Intersection)
?