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XPA and RPA1
Number of citations of the paper that reports this interaction (PMID
7565690
)
52
Data Source:
HPRD
(in vivo, in vitro)
XPA
RPA1
Gene Name
xeroderma pigmentosum, complementation group A
replication protein A1, 70kDa
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Cytoplasm
Golgi Apparatus
Intercellular Bridge
Lateral Element
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
PML Body
Molecular Function
Damaged DNA Binding
Protein Binding
Protein Domain Specific Binding
Protein Homodimerization Activity
Metal Ion Binding
Chromatin Binding
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Metal Ion Binding
Biological Process
Nucleotide-excision Repair, DNA Damage Removal
DNA Repair
Nucleotide-excision Repair
Response To Oxidative Stress
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To UV
Response To Toxic Substance
Multicellular Organism Growth
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Nucleotide-excision Repair, DNA Damage Removal
Telomere Maintenance Via Recombination
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Recombinase Assembly
In Utero Embryonic Development
DNA Replication
DNA-dependent DNA Replication
DNA Strand Elongation Involved In DNA Replication
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, DNA Gap Filling
Mismatch Repair
Double-strand Break Repair
DNA Recombination
Meiotic Nuclear Division
Positive Regulation Of Cell Proliferation
Hemopoiesis
Telomere Maintenance Via Semi-conservative Replication
Cellular Response To Heat
Homeostasis Of Number Of Cells Within A Tissue
Regulation Of Cellular Response To Heat
Pathways
Nucleotide Excision Repair
Global Genomic NER (GG-NER)
Formation of incision complex in GG-NER
Dual incision reaction in GG-NER
HSF1 activation
Gap-filling DNA repair synthesis and ligation in TC-NER
G2/M Checkpoints
Repair synthesis for gap-filling by DNA polymerase in TC-NER
Activation of the pre-replicative complex
DNA strand elongation
Mismatch Repair
G1/S Transition
Homologous recombination repair of replication-independent double-strand breaks
Mitotic G1-G1/S phases
Removal of the Flap Intermediate from the C-strand
Chromosome Maintenance
DNA Replication Pre-Initiation
S Phase
Removal of the Flap Intermediate
Global Genomic NER (GG-NER)
Nucleotide Excision Repair
Activation of the pre-replicative complex
Extension of Telomeres
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Assembly of the RAD51-ssDNA nucleoprotein complex
Telomere Maintenance
Activation of ATR in response to replication stress
Processing of DNA double-strand break ends
Double-Strand Break Repair
Dual incision reaction in GG-NER
Meiotic recombination
Synthesis of DNA
Lagging Strand Synthesis
Processive synthesis on the C-strand of the telomere
Processive synthesis on the lagging strand
M/G1 Transition
Cellular response to heat stress
Regulation of HSF1-mediated heat shock response
Telomere C-strand (Lagging Strand) Synthesis
Presynaptic phase of homologous DNA pairing and strand exchange
Repair synthesis of patch ~27-30 bases long by DNA polymerase
Cell Cycle, Mitotic
Gap-filling DNA repair synthesis and ligation in GG-NER
Homologous DNA pairing and strand exchange
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Transcription-coupled NER (TC-NER)
Homologous Recombination Repair
Formation of incision complex in GG-NER
Cell Cycle Checkpoints
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Thyroid cancer (Papillary, radiation-related) (
20350937
)
Protein-Protein Interactions
20 interactors:
ATM
ATR
DDB1
DDB2
ERCC1
ERCC6
GPN1
GTF2E2
GTF2H1
HERC2
MSH2
MSH3
NDEL1
PRKDC
RASSF1
RPA1
RPA2
RPA4
TRIM27
XAB2
63 interactors:
AICDA
AKTIP
ANXA1
ANXA7
ASCC2
ATM
ATRIP
BID
BLM
BRCA2
BRIP1
CCNA1
CCNA2
CCNB1
CDC5L
CDK1
CDK2
CPE
CSNK2B
DMC1
EXO5
GNB5
HAX1
HELB
HGH1
HNRNPUL1
HUS1
MCM2
MCM4
MCM6
MCM7
MSH4
MTUS2
MUTYH
ORC2
ORC6
PAXIP1
PCNA
POLL
PRKDC
PRPF19
RAD1
RAD23B
RAD51
RAD52
RAD9A
RBM23
RCC1
RECQL
RPA2
RPA3
RPA4
RPS6KA5
SELENBP1
SMAD3
TCEA2
TK1
TP53
TREX1
VIM
WRN
XPA
XPC
Entrez ID
7507
6117
HPRD ID
02045
01565
Ensembl ID
ENSG00000136936
ENSG00000132383
Uniprot IDs
P23025
P27694
PDB IDs
1D4U
1XPA
2JNW
1EWI
1FGU
1JMC
1L1O
2B29
2B3G
4IJH
4IJL
4IPC
4IPD
4IPG
4IPH
Enriched GO Terms of Interacting Partners
?
DNA Repair
Cellular Response To DNA Damage Stimulus
Nucleotide-excision Repair
DNA Metabolic Process
Cellular Response To Stress
Nucleotide-excision Repair, DNA Damage Removal
DNA Recombination
Transcription-coupled Nucleotide-excision Repair
Response To Stress
Double-strand Break Repair
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Response To UV
Cellular Aromatic Compound Metabolic Process
Response To Ionizing Radiation
Response To Radiation
DNA Catabolic Process
DNA Damage Checkpoint
Cellular Nitrogen Compound Metabolic Process
Cell Cycle Process
Response To Abiotic Stimulus
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Nitrogen Compound Metabolic Process
Regulation Of Cellular Response To Heat
Somatic Recombination Of Immunoglobulin Gene Segments
Somatic Diversification Of Immunoglobulins
Cell Cycle Checkpoint
Cell Cycle
Chromosome Organization
Aromatic Compound Catabolic Process
Pyrimidine Dimer Repair
Response To Gamma Radiation
Mismatch Repair
Cellular Response To Stimulus
Immunoglobulin Production
Cellular Macromolecule Catabolic Process
Response To Light Stimulus
Cellular Response To Heat
Telomere Maintenance
Mitotic Cell Cycle Process
Reproduction
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Mitotic DNA Damage Checkpoint
Organelle Organization
Negative Regulation Of DNA Metabolic Process
Mitotic DNA Integrity Checkpoint
Mitotic Cell Cycle
Response To X-ray
Mitotic Recombination
DNA Metabolic Process
Cellular Response To DNA Damage Stimulus
DNA Repair
DNA Replication
Cellular Response To Stress
Cell Cycle Process
Cell Cycle
DNA Damage Checkpoint
Nucleobase-containing Compound Metabolic Process
DNA-dependent DNA Replication
Cellular Nitrogen Compound Metabolic Process
DNA Recombination
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Chromosome Organization
Cell Cycle Checkpoint
Nitrogen Compound Metabolic Process
Mitotic Cell Cycle
Mitotic Cell Cycle Process
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle
Response To Stress
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
DNA Duplex Unwinding
DNA Geometric Change
Double-strand Break Repair
Regulation Of Cell Cycle
Response To Ionizing Radiation
DNA Conformation Change
Nucleotide-excision Repair
Mitotic DNA Damage Checkpoint
Organelle Organization
DNA Catabolic Process
Regulation Of Cell Cycle Process
Mitotic DNA Integrity Checkpoint
Response To Radiation
Mitotic Cell Cycle Checkpoint
Negative Regulation Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Regulation Of Cell Cycle Phase Transition
DNA Strand Elongation Involved In DNA Replication
Cellular Response To Stimulus
Response To Abiotic Stimulus
DNA Strand Elongation
Signal Transduction In Response To DNA Damage
Cellular Response To Ionizing Radiation
Cellular Macromolecule Biosynthetic Process
Tagcloud
?
200a
arthroplasty
backgroundischemia
conclusionsin
david
deeper
degs
downloaded
gabp
geo
insults
inverted
ipc
kegg
limma
mark0
mark1
meanwhile
methodsgse21164
mir141
omnibus
package
ppi
preconditioning
reperfused
resultssignificantly
string
t0
t1
Tagcloud (Difference)
?
200a
arthroplasty
backgroundischemia
conclusionsin
david
deeper
degs
downloaded
gabp
geo
insults
inverted
ipc
kegg
limma
mark0
mark1
meanwhile
methodsgse21164
mir141
omnibus
package
ppi
preconditioning
reperfused
resultssignificantly
string
t0
t1
Tagcloud (Intersection)
?