XPA and DLC1

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		XPA	DLC1
Description		XPA, DNA damage recognition and repair factor	DLC1 Rho GTPase activating protein
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GO Annotations	Cellular Component	Nucleotide-excision Repair Factor 1 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytosol Nuclear Body	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Caveola Focal Adhesion Membrane Cortical Actin Cytoskeleton Ruffle Membrane Membrane Raft Anchoring Junction
	Molecular Function	DNA Binding Damaged DNA Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding Sequence-specific Double-stranded DNA Binding	GTPase Activator Activity Protein Binding Lipid Binding SH2 Domain Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Recognition DNA Repair Base-excision Repair Nucleotide-excision Repair DNA Damage Response Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance UV Protection Regulation Of Autophagy Protein Localization To Nucleus Multicellular Organism Growth Positive Regulation Of Transcription Initiation By RNA Polymerase II UV-damage Excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair	Neural Tube Closure Heart Morphogenesis Signal Transduction Negative Regulation Of Cell Population Proliferation Hindbrain Morphogenesis Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Forebrain Development Regulation Of Rho Protein Signal Transduction Negative Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Execution Phase Of Apoptosis
Pathways		Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Dual incision in TC-NER	RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Serum thyroid-stimulating hormone levels ( 24852370) Thyroid cancer (Papillary, radiation-related) ( 20350937)	Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder ( 30563984) Bipolar disorder ( 22688191) Emphysema imaging phenotypes ( 26030696) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Familial hepatitis B virus-related hepatocellular carcinoma ( 28662289) Fractional exhaled nitric oxide (childhood) ( 24315451) Gestational age at birth (child effect) ( 31194736) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Heel bone mineral density ( 30598549) Height ( 31562340) Intraocular pressure ( 29617998) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Late-onset Alzheimer's disease ( 27770636) LDL cholesterol levels in HIV infection ( 33109212) Lung adenocarcinoma ( 28604730) Metabolite levels ( 23823483) Mild obesity-related type 2 diabetes ( 34737425) Nicotine dependence symptom count ( 25555482) Nose size ( 27182965) Obesity-related traits ( 23251661) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Percentage gas trapping ( 26030696) Platelet distribution width ( 32888494) PR interval ( 32439900) Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 31089300) Waist-hip ratio ( 28552196)
Interacting Genes		51 interacting genes: ARID3A ATM ATR AURKA BMPR1A BUB1 CEP164 DDB1 DDB2 DLC1 DVL3 ERCC1 ERCC6 FBXW7 GPN1 GTF2E2 GTF2H1 HERC2 MEOX2 MLH1 MLH3 MSH2 MSH3 MUTYH NDEL1 NRAS PCNA PDGFRL PICK1 PMS2 POLR1C PRDM16 PRKDC PSMB1 RASSF1 RB1 RHOU RPA1 RPA2 RPA4 SKIL SMAD2 SNPH SRC STK11 TBC1D7 TRIM27 VPS26C XAB2 XPC ZNF655	35 interacting genes: ACOT7 AKT1 AOPEP BAAT CCDC180 CDC14B CORO2A CTSV FANCC FBP2 HEMGN HSD17B3 MAPK3 PFKM PKM PPP3R2 PTEN RANGAP1 RASA1 RHOA RPS6KA1 SFRP4 SMAD1 STX17 TDRD7 TGFB1 TMEFF1 TMEM129 TMOD1 TNS2 TRMO USP4 XPA ZNF189 ZNF510
Entrez ID		7507	10395
HPRD ID		02045	05035
Ensembl ID		ENSG00000136936	ENSG00000164741
Uniprot IDs		P23025	A8K119 Q96QB1
PDB IDs		1D4U 1XPA 2JNW 6J44 6LAE 6RO4 7AD8 8EBT 8EBU 8EBX 8EBY	2DKY 2GYT 2KAP 2LOZ 3KUQ 5FZT 7TPB
Enriched GO Terms of Interacting Partners?		DNA Damage Response DNA Repair Mismatch Repair DNA Metabolic Process Cellular Response To Stress Nucleotide-excision Repair Chromosome Organization Nucleoplasm Nucleic Acid Metabolic Process Regulation Of Cell Cycle Phase Transition ATP-dependent DNA Damage Sensor Activity Damaged DNA Binding Response To UV Single-stranded DNA Binding Response To Stress Negative Regulation Of Cell Cycle Phase Transition Somatic Cell DNA Recombination Mismatched DNA Binding DNA Recombination Chromosome, Telomeric Region Nucleus DNA Binding Cellular Response To UV Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process DNA Damage Checkpoint Signaling Somatic Recombination Of Immunoglobulin Gene Segments Double-strand Break Repair Cellular Response To Light Stimulus Cellular Response To Radiation Regulation Of Cell Cycle Process MutSalpha Complex Binding MutLalpha Complex Binding Somatic Diversification Of Immunoglobulins Response To Radiation Negative Regulation Of Cell Cycle Negative Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Pyrimidine Dimer Repair Negative Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Regulation Of DNA Metabolic Process Telomere Maintenance UV-damage Excision Repair Histone H2AXS139 Kinase Activity Dinucleotide Insertion Or Deletion Binding Regulation Of Mitotic Cell Cycle Protein Localization To Chromosome Response To Light Stimulus Regulation Of Mitotic Cell Cycle Phase Transition	Phosphate-containing Compound Metabolic Process TORC1 Signaling Negative Regulation Of TOR Signaling TOR Signaling Negative Regulation Of Cell Adhesion Negative Regulation Of Transport Glucose Metabolic Process Negative Regulation Of Cell Size Thiolester Hydrolase Activity Fructose 1,6-bisphosphate Metabolic Process Intracellular Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of TORC1 Signaling Regulation Of Transcription By RNA Polymerase II Regulation Of TOR Signaling Hexose Metabolic Process Regulation Of Mononuclear Cell Migration Negative Regulation Of Cell-substrate Adhesion Long-chain Fatty Acyl-CoA Hydrolase Activity Fructose 6-phosphate Metabolic Process Negative Regulation Of Immune Response To Tumor Cell Myelin Maintenance Fatty Acyl-CoA Hydrolase Activity Lens Fiber Cell Differentiation Positive Regulation Of Catalytic Activity Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Fibroblast Migration Monosaccharide Metabolic Process Regulation Of Exit From Mitosis
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