Wiki-Pi
About
Search
People
Updates
Search
XPA and DDB2
Number of citations of the paper that reports this interaction (PubMedID
19056823
)
59
Data Source:
BioGRID
(imaging technique)
HPRD
(in vitro)
XPA
DDB2
Description
XPA, DNA damage recognition and repair factor
damage specific DNA binding protein 2
Image
GO Annotations
Cellular Component
Nucleotide-excision Repair Factor 1 Complex
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Cytosol
Nuclear Body
Chromatin
Nucleus
Nucleoplasm
Chromosome
Cell Junction
Cul4A-RING E3 Ubiquitin Ligase Complex
Cul4B-RING E3 Ubiquitin Ligase Complex
Protein-containing Complex
Cul4-RING E3 Ubiquitin Ligase Complex
Site Of DNA Damage
Molecular Function
DNA Binding
Damaged DNA Binding
Protein Binding
Zinc Ion Binding
Protein Domain Specific Binding
Protein Homodimerization Activity
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
DNA Binding
Damaged DNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Protein-containing Complex Binding
Biological Process
Nucleotide-excision Repair, DNA Damage Recognition
DNA Repair
Base-excision Repair
Nucleotide-excision Repair
DNA Damage Response
Response To Oxidative Stress
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To UV
Response To Toxic Substance
UV Protection
Regulation Of Autophagy
Protein Localization To Nucleus
Multicellular Organism Growth
Positive Regulation Of Transcription Initiation By RNA Polymerase II
UV-damage Excision Repair
Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
Protein Polyubiquitination
DNA Repair
Nucleotide-excision Repair
Pyrimidine Dimer Repair
DNA Damage Response
Response To UV
Protein Ubiquitination
Cellular Response To UV
Protein Autoubiquitination
UV-damage Excision Repair
Pathways
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Ub-specific processing proteases
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
TP53 Regulates Transcription of DNA Repair Genes
Neddylation
Drugs
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
Hypothyroidism (
27182965
)
Obesity-related traits (
23251661
)
Serum thyroid-stimulating hormone levels (
24852370
)
Thyroid cancer (Papillary, radiation-related) (
20350937
)
Acne (severe) (
24399259
)
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Autism spectrum disorder or schizophrenia (
28540026
)
Feeling lonely (
29500382
)
Feeling miserable (
29500382
)
High density lipoprotein cholesterol levels (
33339817
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte percentage of white cells (
32888494
)
Neurociticism (
29500382
)
Neuroticism (
29255261
)
Refractive error (
32231278
)
Triglyceride levels (
32203549
)
Interacting Genes
51 interacting genes:
ARID3A
ATM
ATR
AURKA
BMPR1A
BUB1
CEP164
DDB1
DDB2
DLC1
DVL3
ERCC1
ERCC6
FBXW7
GPN1
GTF2E2
GTF2H1
HERC2
MEOX2
MLH1
MLH3
MSH2
MSH3
MUTYH
NDEL1
NRAS
PCNA
PDGFRL
PICK1
PMS2
POLR1C
PRDM16
PRKDC
PSMB1
RASSF1
RB1
RHOU
RPA1
RPA2
RPA4
SKIL
SMAD2
SNPH
SRC
STK11
TBC1D7
TRIM27
VPS26C
XAB2
XPC
ZNF655
19 interacting genes:
ABL1
AR
CUL4A
CUL4B
DCLRE1C
DDB1
E2F1
H2AC20
H3C14
HDAC1
NR5A2
NTMT1
RAD51
SIRT6
TOP1
USP24
USP40
XPA
XPC
Entrez ID
7507
1643
HPRD ID
02045
02886
Ensembl ID
ENSG00000136936
ENSG00000134574
Uniprot IDs
P23025
Q92466
PDB IDs
1D4U
1XPA
2JNW
6J44
6LAE
6RO4
7AD8
8EBT
8EBU
8EBX
8EBY
3EI4
3I7L
4E54
4E5Z
6R8Y
6R8Z
6R90
6R91
6R92
Enriched GO Terms of Interacting Partners
?
DNA Damage Response
DNA Repair
Mismatch Repair
DNA Metabolic Process
Cellular Response To Stress
Nucleotide-excision Repair
Chromosome Organization
Nucleoplasm
Nucleic Acid Metabolic Process
Regulation Of Cell Cycle Phase Transition
ATP-dependent DNA Damage Sensor Activity
Damaged DNA Binding
Response To UV
Single-stranded DNA Binding
Response To Stress
Negative Regulation Of Cell Cycle Phase Transition
Somatic Cell DNA Recombination
Mismatched DNA Binding
DNA Recombination
Chromosome, Telomeric Region
Nucleus
DNA Binding
Cellular Response To UV
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Cell Cycle Process
DNA Damage Checkpoint Signaling
Somatic Recombination Of Immunoglobulin Gene Segments
Double-strand Break Repair
Cellular Response To Light Stimulus
Cellular Response To Radiation
Regulation Of Cell Cycle Process
MutSalpha Complex Binding
MutLalpha Complex Binding
Somatic Diversification Of Immunoglobulins
Response To Radiation
Negative Regulation Of Cell Cycle
Negative Regulation Of DNA Metabolic Process
Regulation Of Cell Cycle
Pyrimidine Dimer Repair
Negative Regulation Of Mitotic Cell Cycle
Signal Transduction In Response To DNA Damage
Regulation Of DNA Metabolic Process
Telomere Maintenance
UV-damage Excision Repair
Histone H2AXS139 Kinase Activity
Dinucleotide Insertion Or Deletion Binding
Regulation Of Mitotic Cell Cycle
Protein Localization To Chromosome
Response To Light Stimulus
Regulation Of Mitotic Cell Cycle Phase Transition
Damaged DNA Binding
UV-damage Excision Repair
Response To Radiation
Nucleoplasm
DNA Metabolic Process
DNA Repair
DNA Damage Response
Nucleus
Response To UV
DNA Binding
Cellular Response To Radiation
Cellular Response To UV
Macromolecule Metabolic Process
Cellular Response To Light Stimulus
Nucleic Acid Metabolic Process
Chromatin Remodeling
Rhythmic Process
Cul4A-RING E3 Ubiquitin Ligase Complex
Chromatin Binding
Response To Light Stimulus
Chromatin Organization
Cellular Response To Stress
Regulation Of Stem Cell Differentiation
Nucleobase-containing Compound Metabolic Process
Protein Modification Process
Cul4-RING E3 Ubiquitin Ligase Complex
Nuclear Chromosome
Chromosome
Regulation Of Cell Cycle Phase Transition
DNA Damage Sensor Activity
Chromatin
Positive Regulation Of Morphogenesis Of An Epithelium
Base-excision Repair, AP Site Formation Via Deaminated Base Removal
Regulation Of Mitotic Cell Cycle
Response To Xenobiotic Stimulus
Supercoiled DNA Binding
Positive Regulation Of Blood Vessel Branching
Cul4B-RING E3 Ubiquitin Ligase Complex
Regulation Of Morphogenesis Of A Branching Structure
Nucleotide-excision Repair
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Fibroblast Proliferation
Regulation Of Macromolecule Metabolic Process
Chromosome Organization
Regulation Of Blood Vessel Branching
Bubble DNA Binding
Ubiquitin Ligase Complex Scaffold Activity
Positive Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway
Embryonic Cleavage
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?