XPA and XAB2

Number of citations of the paper that reports this interaction (PMID 10944529)
25

Data Source:
HPRD (two hybrid, in vitro)

		XPA	XAB2
Gene Name		xeroderma pigmentosum, complementation group A	XPA binding protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Golgi Apparatus Intercellular Bridge	Nucleus Nucleoplasm Membrane Catalytic Step 2 Spliceosome
	Molecular Function	Damaged DNA Binding Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding	Protein Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal DNA Repair Nucleotide-excision Repair Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Multicellular Organism Growth	MRNA Splicing, Via Spliceosome Blastocyst Development DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription, DNA-templated
Pathways		Nucleotide Excision Repair Global Genomic NER (GG-NER) Formation of incision complex in GG-NER Dual incision reaction in GG-NER	Nucleotide Excision Repair Transcription-coupled NER (TC-NER) Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Protein-Protein Interactions		20 interactors: ATM ATR DDB1 DDB2 ERCC1 ERCC6 GPN1 GTF2E2 GTF2H1 HERC2 MSH2 MSH3 NDEL1 PRKDC RASSF1 RPA1 RPA2 RPA4 TRIM27 XAB2	11 interactors: CACHD1 DHX16 ERCC6 ERCC8 GLIS2 ILF3 ISY1 POLR2A PPIE SMAD9 XPA
Entrez ID		7507	56949
HPRD ID		02045	18306
Ensembl ID		ENSG00000136936	ENSG00000076924
Uniprot IDs		P23025	Q9HCS7
PDB IDs		1D4U 1XPA 2JNW
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus Nucleotide-excision Repair DNA Metabolic Process Cellular Response To Stress Nucleotide-excision Repair, DNA Damage Removal DNA Recombination Transcription-coupled Nucleotide-excision Repair Response To Stress Double-strand Break Repair Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Response To UV Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Response To Radiation DNA Catabolic Process DNA Damage Checkpoint Cellular Nitrogen Compound Metabolic Process Cell Cycle Process Response To Abiotic Stimulus Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Heat Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Cell Cycle Checkpoint Cell Cycle Chromosome Organization Aromatic Compound Catabolic Process Pyrimidine Dimer Repair Response To Gamma Radiation Mismatch Repair Cellular Response To Stimulus Immunoglobulin Production Cellular Macromolecule Catabolic Process Response To Light Stimulus Cellular Response To Heat Telomere Maintenance Mitotic Cell Cycle Process Reproduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Organelle Organization Negative Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Mitotic Cell Cycle Response To X-ray Mitotic Recombination	Nucleotide-excision Repair Nucleobase-containing Compound Metabolic Process Transcription-coupled Nucleotide-excision Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nitrogen Compound Metabolic Process RNA Metabolic Process RNA Splicing Gene Expression Response To UV MRNA Processing Regulation Of Viral Process MRNA Metabolic Process Response To X-ray RNA Processing DNA Repair Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cellular Response To DNA Damage Stimulus Response To Light Stimulus Regulation Of Viral Genome Replication Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Transcription, RNA-templated Response To Radiation DNA Metabolic Process Response To Abiotic Stimulus Multicellular Organism Growth Cellular Metabolic Process Response To Ionizing Radiation Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Response To Toxic Substance Intrinsic Apoptotic Signaling Pathway Mullerian Duct Regression Cellular Response To Stress Activation Of JNKK Activity Pyrimidine Dimer Repair Transcription From RNA Polymerase II Promoter
Tagcloud ?			aspect associates atra cockayne corepressor deacetylase defining dermatologic embryogenesis hl60 imr interfering lethality mol motifs neuroblastoma photoaging physiologic pigmentosum preimplantation preneoplastic promyelocytic raralpha retinoids rhabdomyosarcoma splicing tetratricopeptide xeroderma xpa
Tagcloud (Difference) ?			aspect associates atra cockayne corepressor deacetylase defining dermatologic embryogenesis hl60 imr interfering lethality mol motifs neuroblastoma photoaging physiologic pigmentosum preimplantation preneoplastic promyelocytic raralpha retinoids rhabdomyosarcoma splicing tetratricopeptide xeroderma xpa
Tagcloud (Intersection) ?