XPA and PDGFRL

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		XPA	PDGFRL
Description		XPA, DNA damage recognition and repair factor	platelet derived growth factor receptor like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleotide-excision Repair Factor 1 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytosol Nuclear Body	Extracellular Region
	Molecular Function	DNA Binding Damaged DNA Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Platelet Activating Factor Receptor Activity Platelet-derived Growth Factor Receptor Activity Platelet-derived Growth Factor Beta-receptor Activity
	Biological Process	Nucleotide-excision Repair, DNA Damage Recognition DNA Repair Base-excision Repair Nucleotide-excision Repair DNA Damage Response Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance UV Protection Regulation Of Autophagy Protein Localization To Nucleus Multicellular Organism Growth Positive Regulation Of Transcription Initiation By RNA Polymerase II UV-damage Excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair	G Protein-coupled Receptor Signaling Pathway Platelet-derived Growth Factor Receptor-beta Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Platelet-derived Growth Factor Receptor Signaling Pathway
Pathways		Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Dual incision in TC-NER
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Serum thyroid-stimulating hormone levels ( 24852370) Thyroid cancer (Papillary, radiation-related) ( 20350937)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Hippocampal volume in normal cognition ( 29274321) Placental abruption ( 29884306) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma parathyroid hormone levels ( 30134803) Spatial memory ( 31596458) Sphingomyelin 24:0 levels ( 31560688)
Interacting Genes		51 interacting genes: ARID3A ATM ATR AURKA BMPR1A BUB1 CEP164 DDB1 DDB2 DLC1 DVL3 ERCC1 ERCC6 FBXW7 GPN1 GTF2E2 GTF2H1 HERC2 MEOX2 MLH1 MLH3 MSH2 MSH3 MUTYH NDEL1 NRAS PCNA PDGFRL PICK1 PMS2 POLR1C PRDM16 PRKDC PSMB1 RASSF1 RB1 RHOU RPA1 RPA2 RPA4 SKIL SMAD2 SNPH SRC STK11 TBC1D7 TRIM27 VPS26C XAB2 XPC ZNF655	24 interacting genes: ASPH BAAT CCDC180 CTSV FANCC FBP2 HRAS MAP2K1 MAPK12 MAPK3 MBP NANS PFKM PPP2CB PPP3R2 RANGAP1 SFRP4 SMAD1 SPARCL1 TBC1D2 TGFB1 TMEM129 XPA ZNF510
Entrez ID		7507	5157
HPRD ID		02045	05206
Ensembl ID		ENSG00000136936	ENSG00000104213
Uniprot IDs		P23025	Q15198
PDB IDs		1D4U 1XPA 2JNW 6J44 6LAE 6RO4 7AD8 8EBT 8EBU 8EBX 8EBY
Enriched GO Terms of Interacting Partners?		DNA Damage Response DNA Repair Mismatch Repair DNA Metabolic Process Cellular Response To Stress Nucleotide-excision Repair Chromosome Organization Nucleoplasm Nucleic Acid Metabolic Process Regulation Of Cell Cycle Phase Transition ATP-dependent DNA Damage Sensor Activity Damaged DNA Binding Response To UV Single-stranded DNA Binding Response To Stress Negative Regulation Of Cell Cycle Phase Transition Somatic Cell DNA Recombination Mismatched DNA Binding DNA Recombination Chromosome, Telomeric Region Nucleus DNA Binding Cellular Response To UV Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process DNA Damage Checkpoint Signaling Somatic Recombination Of Immunoglobulin Gene Segments Double-strand Break Repair Cellular Response To Light Stimulus Cellular Response To Radiation Regulation Of Cell Cycle Process MutSalpha Complex Binding MutLalpha Complex Binding Somatic Diversification Of Immunoglobulins Response To Radiation Negative Regulation Of Cell Cycle Negative Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Pyrimidine Dimer Repair Negative Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Regulation Of DNA Metabolic Process Telomere Maintenance UV-damage Excision Repair Histone H2AXS139 Kinase Activity Dinucleotide Insertion Or Deletion Binding Regulation Of Mitotic Cell Cycle Protein Localization To Chromosome Response To Light Stimulus Regulation Of Mitotic Cell Cycle Phase Transition	Myelination Axon Ensheathment MAPK Cascade Regulation Of Intracellular Transport Glial Cell Development Schwann Cell Development Regulation Of Cellular Localization Regulation Of Golgi Inheritance Intracellular Signaling Cassette Trachea Formation Regulation Of Intracellular Protein Transport Fructose 1,6-bisphosphate Metabolic Process ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of Establishment Of Protein Localization Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Catalytic Activity Bergmann Glial Cell Differentiation Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of ERK1 And ERK2 Cascade Chemical Homeostasis Cytosol Fructose 6-phosphate Metabolic Process Negative Regulation Of Immune Response To Tumor Cell Negative Regulation Of Cell-cell Adhesion Regulation Of Transport Regulation Of Protein Localization MAP Kinase Activity Positive Regulation Of Intracellular Protein Transport Regulation Of MiRNA Metabolic Process Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Golgi Organization Regulation Of Early Endosome To Late Endosome Transport Homeostatic Process Negative Regulation Of Transport Regulation Of Protein Transport Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Protein Transport Animal Organ Formation Face Development Negative Regulation Of Cell Population Proliferation ERBB2 Signaling Pathway Intracellular Signal Transduction Gland Development Positive Regulation Of Hydrolase Activity Muscle Cell Cellular Homeostasis Regulation Of Protein Localization To Synapse Lung Morphogenesis
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