XPA and ERCC1

Number of citations of the paper that reports this interaction (PMID 8197174)
83

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		XPA	ERCC1
Gene Name		xeroderma pigmentosum, complementation group A	excision repair cross-complementation group 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Golgi Apparatus Intercellular Bridge	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Nuclear Chromosome, Telomeric Region Nucleoplasm Transcription Factor TFIID Complex Cytoplasm
	Molecular Function	Damaged DNA Binding Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Protein C-terminus Binding TBP-class Protein Binding Protein Domain Specific Binding Structure-specific DNA Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal DNA Repair Nucleotide-excision Repair Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Multicellular Organism Growth	Nucleotide-excision Repair, DNA Damage Removal Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Catabolic Process, Endonucleolytic Replicative Cell Aging DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Double-strand Break Repair DNA Recombination Mitotic Recombination Syncytium Formation Response To Oxidative Stress Spermatogenesis Response To Nutrient Cell Proliferation Male Gonad Development UV Protection Response To Sucrose Response To X-ray Multicellular Organismal Aging Negative Regulation Of Telomere Maintenance Post-embryonic Hemopoiesis Multicellular Organism Growth Interstrand Cross-link Repair Isotype Switching Oogenesis Embryonic Organ Development Chromosome Organization
Pathways		Nucleotide Excision Repair Global Genomic NER (GG-NER) Formation of incision complex in GG-NER Dual incision reaction in GG-NER	Nucleotide Excision Repair Global Genomic NER (GG-NER) Transcription-coupled NER (TC-NER) Formation of incision complex in GG-NER Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in GG-NER Dual incision reaction in TC-NER
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Protein-Protein Interactions		20 interactors: ATM ATR DDB1 DDB2 ERCC1 ERCC6 GPN1 GTF2E2 GTF2H1 HERC2 MSH2 MSH3 NDEL1 PRKDC RASSF1 RPA1 RPA2 RPA4 TRIM27 XAB2	8 interactors: ERCC4 MKRN3 SLX1A TRMT2B UBL7 USHBP1 VPS37B XPA
Entrez ID		7507	2067
HPRD ID		02045	00533
Ensembl ID		ENSG00000136936	ENSG00000012061
Uniprot IDs		P23025	P07992
PDB IDs		1D4U 1XPA 2JNW	1Z00 2A1I 2A1J 2JNW 2JPD
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus Nucleotide-excision Repair DNA Metabolic Process Cellular Response To Stress Nucleotide-excision Repair, DNA Damage Removal DNA Recombination Transcription-coupled Nucleotide-excision Repair Response To Stress Double-strand Break Repair Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Response To UV Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Response To Radiation DNA Catabolic Process DNA Damage Checkpoint Cellular Nitrogen Compound Metabolic Process Cell Cycle Process Response To Abiotic Stimulus Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Heat Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Cell Cycle Checkpoint Cell Cycle Chromosome Organization Aromatic Compound Catabolic Process Pyrimidine Dimer Repair Response To Gamma Radiation Mismatch Repair Cellular Response To Stimulus Immunoglobulin Production Cellular Macromolecule Catabolic Process Response To Light Stimulus Cellular Response To Heat Telomere Maintenance Mitotic Cell Cycle Process Reproduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Organelle Organization Negative Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Mitotic Cell Cycle Response To X-ray Mitotic Recombination	DNA Catabolic Process Nucleotide-excision Repair, DNA Damage Removal Aromatic Compound Catabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Catabolic Process, Endonucleolytic Nucleotide-excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair DNA Repair Response To UV Double-strand Break Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Incision, 3'-to Lesion DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Telomere Maintenance Via Telomere Shortening DNA Recombination DNA Metabolic Process Nucleotide-excision Repair, DNA Incision DNA Double-strand Break Processing Interstrand Cross-link Repair Negative Regulation Of Telomere Maintenance Nucleic Acid Phosphodiester Bond Hydrolysis Viral Protein Processing Response To Light Stimulus Resolution Of Meiotic Recombination Intermediates UV Protection Cellular Response To Stress Regulation Of Telomere Maintenance Response To Radiation Chromosome Separation Virion Assembly TRNA Methylation Intracellular Transport Of Virus Catabolic Process DNA Catabolic Process, Exonucleolytic Transcription-coupled Nucleotide-excision Repair Reciprocal Meiotic Recombination Nucleobase-containing Compound Metabolic Process RNA Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process TRNA Modification Telomere Maintenance Cellular Nitrogen Compound Metabolic Process Meiotic Chromosome Segregation Negative Regulation Of Chromosome Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Metabolic Process
Tagcloud ?			3b aa8 adp antiapoptotic became carrying cho concordance confer delay determinant ercc3 erk2 excision g5 hamster mtt ner ovary pair parental phosphatidylinositol pi player repair ribose uv24 withdrawal xpb
Tagcloud (Difference) ?			3b aa8 adp antiapoptotic became carrying cho concordance confer delay determinant ercc3 erk2 excision g5 hamster mtt ner ovary pair parental phosphatidylinositol pi player repair ribose uv24 withdrawal xpb
Tagcloud (Intersection) ?