XPA and RPA4

Number of citations of the paper that reports this interaction (PMID 7565690)
52

Data Source:
HPRD (two hybrid, in vitro)

		XPA	RPA4
Gene Name		xeroderma pigmentosum, complementation group A	replication protein A4, 30kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Golgi Apparatus Intercellular Bridge	Nucleus Nucleoplasm DNA Replication Factor A Complex
	Molecular Function	Damaged DNA Binding Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding	Single-stranded DNA Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal DNA Repair Nucleotide-excision Repair Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Multicellular Organism Growth	DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Initiation Nucleotide-excision Repair DNA Recombination Nuclear DNA Replication
Pathways		Nucleotide Excision Repair Global Genomic NER (GG-NER) Formation of incision complex in GG-NER Dual incision reaction in GG-NER	G1/S Transition Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Activation of the pre-replicative complex Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Protein-Protein Interactions		20 interactors: ATM ATR DDB1 DDB2 ERCC1 ERCC6 GPN1 GTF2E2 GTF2H1 HERC2 MSH2 MSH3 NDEL1 PRKDC RASSF1 RPA1 RPA2 RPA4 TRIM27 XAB2	7 interactors: APP MSH2 MSH3 MUTYH RPA1 RPA3 XPA
Entrez ID		7507	29935
HPRD ID		02045	06591
Ensembl ID		ENSG00000136936	ENSG00000204086
Uniprot IDs		P23025	Q13156
PDB IDs		1D4U 1XPA 2JNW
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus Nucleotide-excision Repair DNA Metabolic Process Cellular Response To Stress Nucleotide-excision Repair, DNA Damage Removal DNA Recombination Transcription-coupled Nucleotide-excision Repair Response To Stress Double-strand Break Repair Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Response To UV Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Response To Radiation DNA Catabolic Process DNA Damage Checkpoint Cellular Nitrogen Compound Metabolic Process Cell Cycle Process Response To Abiotic Stimulus Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Heat Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Cell Cycle Checkpoint Cell Cycle Chromosome Organization Aromatic Compound Catabolic Process Pyrimidine Dimer Repair Response To Gamma Radiation Mismatch Repair Cellular Response To Stimulus Immunoglobulin Production Cellular Macromolecule Catabolic Process Response To Light Stimulus Cellular Response To Heat Telomere Maintenance Mitotic Cell Cycle Process Reproduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Organelle Organization Negative Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Mitotic Cell Cycle Response To X-ray Mitotic Recombination	Mismatch Repair DNA Repair Nucleotide-excision Repair, DNA Damage Removal Cellular Response To DNA Damage Stimulus DNA Catabolic Process DNA Metabolic Process Meiotic Mismatch Repair DNA Recombination Maintenance Of DNA Repeat Elements Cellular Response To Stress Base-excision Repair DNA Recombinase Assembly Positive Regulation Of Helicase Activity Response To Stress Nucleotide-excision Repair Response To Abiotic Stimulus Aromatic Compound Catabolic Process Double-strand Break Repair Nucleotide-excision Repair, DNA Gap Filling Nucleobase-containing Compound Metabolic Process Meiotic Nuclear Division Telomere Maintenance Via Semi-conservative Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of DNA Recombination Nuclear DNA Replication Telomere Maintenance Via Recombination Cellular Nitrogen Compound Metabolic Process Meiotic Cell Cycle Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Regulation Of Cellular Response To Heat DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Nitrogen Compound Metabolic Process Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Cellular Macromolecule Catabolic Process Transcription-coupled Nucleotide-excision Repair Response To Light Stimulus Chromosome Organization Reproduction Cell Cycle Process Cellular Response To Stimulus Immunoglobulin Production Cellular Response To Heat Regulation Of DNA Recombination Regulation Of Mitotic Cell Cycle Telomere Maintenance Response To Radiation
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