XPA and FBXW7

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		XPA	FBXW7
Description		XPA, DNA damage recognition and repair factor	F-box and WD repeat domain containing 7
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GO Annotations	Cellular Component	Nucleotide-excision Repair Factor 1 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytosol Nuclear Body	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Protein-containing Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
	Molecular Function	DNA Binding Damaged DNA Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Cyclin Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Binding Phosphothreonine Residue Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Nucleotide-excision Repair, DNA Damage Recognition DNA Repair Base-excision Repair Nucleotide-excision Repair DNA Damage Response Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance UV Protection Regulation Of Autophagy Protein Localization To Nucleus Multicellular Organism Growth Positive Regulation Of Transcription Initiation By RNA Polymerase II UV-damage Excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair	G1/S Transition Of Mitotic Cell Cycle Vasculature Development DNA Repair DNA Damage Response Sister Chromatid Cohesion Regulation Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of Triglyceride Biosynthetic Process Regulation Of Lipid Storage Ubiquitin Recycling Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Cellular Response To UV Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Protein Stabilization Lipid Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Mitophagy Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Osteoclast Development
Pathways		Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Dual incision in TC-NER	Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Serum thyroid-stimulating hormone levels ( 24852370) Thyroid cancer (Papillary, radiation-related) ( 20350937)	Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494)
Interacting Genes		51 interacting genes: ARID3A ATM ATR AURKA BMPR1A BUB1 CEP164 DDB1 DDB2 DLC1 DVL3 ERCC1 ERCC6 FBXW7 GPN1 GTF2E2 GTF2H1 HERC2 MEOX2 MLH1 MLH3 MSH2 MSH3 MUTYH NDEL1 NRAS PCNA PDGFRL PICK1 PMS2 POLR1C PRDM16 PRKDC PSMB1 RASSF1 RB1 RHOU RPA1 RPA2 RPA4 SKIL SMAD2 SNPH SRC STK11 TBC1D7 TRIM27 VPS26C XAB2 XPC ZNF655	84 interacting genes: ACD AHSG AKT1 ANGPTL4 ANP32B ARL6IP1 BCAS3 BEX1 BLM CCDC6 CCNE1 CCNE2 CDC34 CEBPD CUL1 DISC1 DVL1 DYRK2 EBNA1BP2 EXT1 EZH2 FANCC FBP2 FBXO45 GALNT12 GATA2 GATA3 GFI1 GLMN HEMGN HEY1 HIPK2 HNRNPK HRAS IGFBP3 IL24 JUN KLF10 KLF5 LINGO1 MALAT1 MAP2K1 MAPK3 MMS22L MYB MYC MYCN NANS NIP7 NOTCH1 NOTCH4 NOX1 PLK1 PPARGC1A PPP3R2 PRKN PSEN1 RFLNA SCGB3A1 SEC61B SHC1 SHOC2 SHPRH SIK2 SKP1 SMAD1 SNCA SP7 SPI1 STAT3 STAT5A STOML1 STYX SUMF2 TGFB1 TMOD1 TRIP12 TSC22D4 USP2 WDR5 WDR97 XPA YAP1 ZNF510
Entrez ID		7507	55294
HPRD ID		02045	05888
Ensembl ID		ENSG00000136936	ENSG00000109670
Uniprot IDs		P23025	G0Z2K0 Q969H0 S4R3U4
PDB IDs		1D4U 1XPA 2JNW 6J44 6LAE 6RO4 7AD8 8EBT 8EBU 8EBX 8EBY	2OVP 2OVQ 2OVR 5IBK 5V4B 7T1Y 7T1Z
Enriched GO Terms of Interacting Partners?		DNA Damage Response DNA Repair Mismatch Repair DNA Metabolic Process Cellular Response To Stress Nucleotide-excision Repair Chromosome Organization Nucleoplasm Nucleic Acid Metabolic Process Regulation Of Cell Cycle Phase Transition ATP-dependent DNA Damage Sensor Activity Damaged DNA Binding Response To UV Single-stranded DNA Binding Response To Stress Negative Regulation Of Cell Cycle Phase Transition Somatic Cell DNA Recombination Mismatched DNA Binding DNA Recombination Chromosome, Telomeric Region Nucleus DNA Binding Cellular Response To UV Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process DNA Damage Checkpoint Signaling Somatic Recombination Of Immunoglobulin Gene Segments Double-strand Break Repair Cellular Response To Light Stimulus Cellular Response To Radiation Regulation Of Cell Cycle Process MutSalpha Complex Binding MutLalpha Complex Binding Somatic Diversification Of Immunoglobulins Response To Radiation Negative Regulation Of Cell Cycle Negative Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Pyrimidine Dimer Repair Negative Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Regulation Of DNA Metabolic Process Telomere Maintenance UV-damage Excision Repair Histone H2AXS139 Kinase Activity Dinucleotide Insertion Or Deletion Binding Regulation Of Mitotic Cell Cycle Protein Localization To Chromosome Response To Light Stimulus Regulation Of Mitotic Cell Cycle Phase Transition	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MiRNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Transcription Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Metabolic Process Cellular Response To Stress Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Developmental Process Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Developmental Process Cell Population Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Metabolic Process Gland Development Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Multicellular Organismal Development Regulation Of Apoptotic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Negative Regulation Of Developmental Process Negative Regulation Of Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cell Differentiation Apoptotic Process Regulation Of Multicellular Organismal Process
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