XPA and DDB1

Number of citations of the paper that reports this interaction (PubMedID 19056823)
59

Data Source:
BioGRID (pull down)

		XPA	DDB1
Description		XPA, DNA damage recognition and repair factor	damage specific DNA binding protein 1
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GO Annotations	Cellular Component	Nucleotide-excision Repair Factor 1 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytosol Nuclear Body	Chromosome, Telomeric Region Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Site Of Double-strand Break Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	DNA Binding Damaged DNA Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Nucleic Acid Binding DNA Binding Damaged DNA Binding Protein Binding Protein-macromolecule Adaptor Activity Protein-containing Complex Binding WD40-repeat Domain Binding Cullin Family Protein Binding Ubiquitin Ligase Complex Scaffold Activity
	Biological Process	Nucleotide-excision Repair, DNA Damage Recognition DNA Repair Base-excision Repair Nucleotide-excision Repair DNA Damage Response Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance UV Protection Regulation Of Autophagy Protein Localization To Nucleus Multicellular Organism Growth Positive Regulation Of Transcription Initiation By RNA Polymerase II UV-damage Excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair	DNA Repair Nucleotide-excision Repair Ubiquitin-dependent Protein Catabolic Process Apoptotic Process DNA Damage Response Spindle Assembly Involved In Female Meiosis Proteasomal Protein Catabolic Process Wnt Signaling Pathway Protein Ubiquitination Viral Release From Host Cell Cellular Response To UV Ectopic Germ Cell Programmed Cell Death Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Epigenetic Programming In The Zygotic Pronuclei Positive Regulation Of Viral Genome Replication Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Catabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Rhythmic Process Negative Regulation Of Developmental Process Biological Process Involved In Interaction With Symbiont Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Type I Interferon-mediated Signaling Pathway UV-damage Excision Repair Base-excision Repair, AP Site Formation Via Deaminated Base Removal Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Reproductive Process
Pathways		Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Dual incision in TC-NER	Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome	Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Serum thyroid-stimulating hormone levels ( 24852370) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Interacting Genes		51 interacting genes: ARID3A ATM ATR AURKA BMPR1A BUB1 CEP164 DDB1 DDB2 DLC1 DVL3 ERCC1 ERCC6 FBXW7 GPN1 GTF2E2 GTF2H1 HERC2 MEOX2 MLH1 MLH3 MSH2 MSH3 MUTYH NDEL1 NRAS PCNA PDGFRL PICK1 PMS2 POLR1C PRDM16 PRKDC PSMB1 RASSF1 RB1 RHOU RPA1 RPA2 RPA4 SKIL SMAD2 SNPH SRC STK11 TBC1D7 TRIM27 VPS26C XAB2 XPC ZNF655	54 interacting genes: ABL1 ANXA1 BCAS3 BRAP BRWD3 CCNK CDK12 CNOT2 COPS5 CUL4A CUL4B DCAF11 DCAF8 DDB2 DET1 DNMT3A DNMT3B DTL EME1 ERCC8 H1-2 H3C1 HOXD3 IKZF1 IP6K1 LMO4 MEF2A MTA2 MUS81 PIN1 POLH PPDPF PTEN RASSF1 RBBP4 RBBP7 RNF26 SALL2 SHANK3 SIN3A SKP2 SNAI1 STAT1 SUPT3H TBL1X TBL1XR1 TP73 USP40 VAMP3 WDTC1 WIPI2 XPA ZEB2 ZNF277
Entrez ID		7507	1642
HPRD ID		02045	10952
Ensembl ID		ENSG00000136936	ENSG00000167986
Uniprot IDs		P23025	Q16531
PDB IDs		1D4U 1XPA 2JNW 6J44 6LAE 6RO4 7AD8 8EBT 8EBU 8EBX 8EBY	2B5L 2B5M 2B5N 2HYE 3E0C 3EI1 3EI2 3EI3 3EI4 3I7H 3I7K 3I7L 3I7N 3I7O 3I7P 3I89 3I8C 3I8E 4A08 4A09 4A0A 4A0B 4A0K 4A0L 4A11 4CI1 4CI2 4CI3 4E54 4E5Z 4TZ4 5FQD 5HXB 5JK7 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6DSZ 6FCV 6H0F 6H0G 6PAI 6Q0R 6Q0V 6Q0W 6R8Y 6R8Z 6R90 6R91 6R92 6SJ7 6TD3 6UD7 6UE5 6UML 6XK9 6ZUE 6ZX9 7LPS 7OKQ 7OO3 7OOB 7OOP 7OPC 7OPD 7U8F 7UKN 7V7B 7V7C 7ZN7 7ZNN 8AJM 8AJN 8AJO 8B3D 8B3F 8B3G 8B3I 8BU1 8BU2 8BU3 8BU4 8BU5 8BU6 8BU7 8BU9 8BUA 8BUB 8BUC 8BUD 8BUE 8BUF 8BUG 8BUH 8BUI 8BUJ 8BUK 8BUL 8BUM 8BUN 8BUO 8BUP 8BUQ 8BUR 8BUS 8BUT 8CVP 8D7U 8D7V 8D7W 8D7X 8D7Y 8D7Z 8D80 8D81 8DEY 8G46 8G66 8OIZ 8OJH 8OV6 8QH5 8ROX 8ROY 8T9A 8TL6 8TNP 8TNQ 8TNR 8TZX 8U15 8U16 8U17 8UH6 8WQR 9BBE 9BBG 9BBH 9BBI 9BZ0 9DHD 9DJT 9DJX 9DQD 9EJQ 9ER2 9FD2 9FJX 9FMR
Enriched GO Terms of Interacting Partners?		DNA Damage Response DNA Repair Mismatch Repair DNA Metabolic Process Cellular Response To Stress Nucleotide-excision Repair Chromosome Organization Nucleoplasm Nucleic Acid Metabolic Process Regulation Of Cell Cycle Phase Transition ATP-dependent DNA Damage Sensor Activity Damaged DNA Binding Response To UV Single-stranded DNA Binding Response To Stress Negative Regulation Of Cell Cycle Phase Transition Somatic Cell DNA Recombination Mismatched DNA Binding DNA Recombination Chromosome, Telomeric Region Nucleus DNA Binding Cellular Response To UV Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process DNA Damage Checkpoint Signaling Somatic Recombination Of Immunoglobulin Gene Segments Double-strand Break Repair Cellular Response To Light Stimulus Cellular Response To Radiation Regulation Of Cell Cycle Process MutSalpha Complex Binding MutLalpha Complex Binding Somatic Diversification Of Immunoglobulins Response To Radiation Negative Regulation Of Cell Cycle Negative Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Pyrimidine Dimer Repair Negative Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Regulation Of DNA Metabolic Process Telomere Maintenance UV-damage Excision Repair Histone H2AXS139 Kinase Activity Dinucleotide Insertion Or Deletion Binding Regulation Of Mitotic Cell Cycle Protein Localization To Chromosome Response To Light Stimulus Regulation Of Mitotic Cell Cycle Phase Transition	Cul4-RING E3 Ubiquitin Ligase Complex Nucleoplasm Nucleus Regulation Of Transcription By RNA Polymerase II Cul4A-RING E3 Ubiquitin Ligase Complex Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone Deacetylase Complex DNA Metabolic Process Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process DNA Repair DNA Damage Response Positive Regulation Of Biosynthetic Process Regulation Of Cell Cycle DNA Binding Response To Stress Protein Modification By Small Protein Conjugation Post-translational Protein Modification Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process Protein Ubiquitination Regulation Of Mitotic Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To UV Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of Cell Fate Specification Negative Regulation Of RNA Metabolic Process Histone Binding Protein Modification Process Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process
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