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XPA
Description
XPA, DNA damage recognition and repair factor
Image
GO Annotations
Cellular Component
Nucleotide-excision Repair Factor 1 Complex
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Cytosol
Nuclear Body
Molecular Function
DNA Binding
Damaged DNA Binding
Protein Binding
Zinc Ion Binding
Protein Domain Specific Binding
Protein Homodimerization Activity
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Nucleotide-excision Repair, DNA Damage Recognition
DNA Repair
Base-excision Repair
Nucleotide-excision Repair
DNA Damage Response
Response To Oxidative Stress
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To UV
Response To Toxic Substance
UV Protection
Regulation Of Autophagy
Protein Localization To Nucleus
Multicellular Organism Growth
Positive Regulation Of Transcription Initiation By RNA Polymerase II
UV-damage Excision Repair
Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
Pathways
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Drugs
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
Hypothyroidism (
27182965
)
Obesity-related traits (
23251661
)
Serum thyroid-stimulating hormone levels (
24852370
)
Thyroid cancer (Papillary, radiation-related) (
20350937
)
Novel Interacting Genes
1 novel interacting genes:
AP2M1
Interacting Genes
51 interacting genes:
ARID3A
ATM
ATR
AURKA
BMPR1A
BUB1
CEP164
DDB1
DDB2
DLC1
DVL3
ERCC1
ERCC6
FBXW7
GPN1
GTF2E2
GTF2H1
HERC2
MEOX2
MLH1
MLH3
MSH2
MSH3
MUTYH
NDEL1
NRAS
PCNA
PDGFRL
PICK1
PMS2
POLR1C
PRDM16
PRKDC
PSMB1
RASSF1
RB1
RHOU
RPA1
RPA2
RPA4
SKIL
SMAD2
SNPH
SRC
STK11
TBC1D7
TRIM27
VPS26C
XAB2
XPC
ZNF655
Entrez ID
7507
HPRD ID
02045
Ensembl ID
ENSG00000136936
Uniprot IDs
P23025
PDB IDs
1D4U
1XPA
2JNW
6J44
6LAE
6RO4
7AD8
8EBT
8EBU
8EBX
8EBY
Enriched GO Terms of Interacting Partners
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DNA Damage Response
DNA Repair
Mismatch Repair
DNA Metabolic Process
Cellular Response To Stress
Nucleotide-excision Repair
Chromosome Organization
Nucleoplasm
Nucleic Acid Metabolic Process
Regulation Of Cell Cycle Phase Transition
ATP-dependent DNA Damage Sensor Activity
Damaged DNA Binding
Response To UV
Single-stranded DNA Binding
Response To Stress
Negative Regulation Of Cell Cycle Phase Transition
Somatic Cell DNA Recombination
Mismatched DNA Binding
DNA Recombination
Chromosome, Telomeric Region
Nucleus
DNA Binding
Cellular Response To UV
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Cell Cycle Process
DNA Damage Checkpoint Signaling
Somatic Recombination Of Immunoglobulin Gene Segments
Double-strand Break Repair
Cellular Response To Light Stimulus
Cellular Response To Radiation
Regulation Of Cell Cycle Process
MutSalpha Complex Binding
MutLalpha Complex Binding
Somatic Diversification Of Immunoglobulins
Response To Radiation
Negative Regulation Of Cell Cycle
Negative Regulation Of DNA Metabolic Process
Regulation Of Cell Cycle
Pyrimidine Dimer Repair
Negative Regulation Of Mitotic Cell Cycle
Signal Transduction In Response To DNA Damage
Regulation Of DNA Metabolic Process
Telomere Maintenance
UV-damage Excision Repair
Histone H2AXS139 Kinase Activity
Dinucleotide Insertion Or Deletion Binding
Regulation Of Mitotic Cell Cycle
Protein Localization To Chromosome
Response To Light Stimulus
Regulation Of Mitotic Cell Cycle Phase Transition
Tagcloud
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