XPA and PRKDC

Number of citations of the paper that reports this interaction (PMID 16540648)
26

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		XPA	PRKDC
Gene Name		xeroderma pigmentosum, complementation group A	protein kinase, DNA-activated, catalytic polypeptide
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Golgi Apparatus Intercellular Bridge	Nucleoplasm Transcription Factor Complex Nucleolus Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex Membrane Nonhomologous End Joining Complex
	Molecular Function	Damaged DNA Binding Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding	DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Enzyme Binding Poly(A) RNA Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal DNA Repair Nucleotide-excision Repair Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Multicellular Organism Growth	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Somitogenesis Negative Regulation Of Protein Phosphorylation B Cell Lineage Commitment Pro-B Cell Differentiation T Cell Lineage Commitment DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cellular Protein Modification Process Brain Development Heart Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Peptidyl-serine Phosphorylation Protein Destabilization Positive Regulation Of Type I Interferon Production Cellular Response To Insulin Stimulus T Cell Differentiation In Thymus Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Ectopic Germ Cell Programmed Cell Death Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Pathways		Nucleotide Excision Repair Global Genomic NER (GG-NER) Formation of incision complex in GG-NER Dual incision reaction in GG-NER	Nonhomologous End-joining (NHEJ) Cytosolic sensors of pathogen-associated DNA Processing of DNA ends prior to end rejoining STING mediated induction of host immune responses Double-Strand Break Repair IRF3-mediated induction of type I IFN Innate Immune System
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Protein-Protein Interactions		20 interactors: ATM ATR DDB1 DDB2 ERCC1 ERCC6 GPN1 GTF2E2 GTF2H1 HERC2 MSH2 MSH3 NDEL1 PRKDC RASSF1 RPA1 RPA2 RPA4 TRIM27 XAB2	83 interactors: ABL1 AICDA AKT1 AKT2 AP1B1 ATM ATRIP BRCA1 C1D CASP3 CHEK1 CHEK2 CHUK CIB1 CTDP1 DCLRE1C E4F1 EIF2S2 EIF4EBP1 ERG GSK3A GSK3B GZMB H2AFX HDAC3 HIST1H1A HIST1H1C HMGB1 HMGB2 HNRNPA1 HNRNPC HOXC4 HSF1 HSP90AA1 IKBKB ILF2 JUN KAT2A LIG4 LYN MAPK8 MBP MKNK1 MRE11A NBN NCF1 NCF2 NCF4 NCOA6 NR3C1 PARP1 PCNA PDX1 PGR POU2F1 PPP6C PPP6R1 PPP6R2 PPP6R3 PRKCD PTS RAD17 RBBP8 RNF144A RPA1 RPA2 SGOL1 SP1 SRF THRA THRB TP53 TREX1 UBC USF1 VPRBP WRN XPA XRCC4 XRCC5 XRCC6 YWHAG YWHAQ
Entrez ID		7507	5591
HPRD ID		02045	02941
Ensembl ID		ENSG00000136936	ENSG00000253729
Uniprot IDs		P23025	P78527
PDB IDs		1D4U 1XPA 2JNW
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus Nucleotide-excision Repair DNA Metabolic Process Cellular Response To Stress Nucleotide-excision Repair, DNA Damage Removal DNA Recombination Transcription-coupled Nucleotide-excision Repair Response To Stress Double-strand Break Repair Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Response To UV Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Response To Radiation DNA Catabolic Process DNA Damage Checkpoint Cellular Nitrogen Compound Metabolic Process Cell Cycle Process Response To Abiotic Stimulus Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Heat Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Cell Cycle Checkpoint Cell Cycle Chromosome Organization Aromatic Compound Catabolic Process Pyrimidine Dimer Repair Response To Gamma Radiation Mismatch Repair Cellular Response To Stimulus Immunoglobulin Production Cellular Macromolecule Catabolic Process Response To Light Stimulus Cellular Response To Heat Telomere Maintenance Mitotic Cell Cycle Process Reproduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Organelle Organization Negative Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Mitotic Cell Cycle Response To X-ray Mitotic Recombination	Cellular Response To Stress DNA Repair Cellular Response To DNA Damage Stimulus DNA Recombination DNA Metabolic Process Double-strand Break Repair Response To Stress Immune System Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Apoptotic Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Response To Abiotic Stimulus Positive Regulation Of Metabolic Process Cellular Response To Stimulus Response To Organic Substance Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Immune System Development Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cell Cycle Cellular Response To Organic Substance Regulation Of Nitrogen Compound Metabolic Process Apoptotic Process Organelle Organization Cellular Metabolic Process Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Process Cell Death Death Telomere Maintenance Developmental Process Immune Response Regulation Of Transcription From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway DNA Damage Checkpoint Cellular Macromolecule Biosynthetic Process Response To Stimulus Mitotic Cell Cycle Macromolecule Biosynthetic Process Response To Radiation Organ Development Mitotic Cell Cycle Process
Tagcloud ?			1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic il2rg loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer reconstituted ritonavir szj tm1wjl untargeted
Tagcloud (Difference) ?			1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic il2rg loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer reconstituted ritonavir szj tm1wjl untargeted
Tagcloud (Intersection) ?