XPA and CEP164

Number of citations of the paper that reports this interaction (PubMedID 19197159)
0

Data Source:
BioGRID (pull down)

		XPA	CEP164
Description		XPA, DNA damage recognition and repair factor	centrosomal protein 164
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GO Annotations	Cellular Component	Nucleotide-excision Repair Factor 1 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytosol Nuclear Body	Extracellular Space Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Ciliary Transition Fiber
	Molecular Function	DNA Binding Damaged DNA Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Recognition DNA Repair Base-excision Repair Nucleotide-excision Repair DNA Damage Response Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance UV Protection Regulation Of Autophagy Protein Localization To Nucleus Multicellular Organism Growth Positive Regulation Of Transcription Initiation By RNA Polymerase II UV-damage Excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair	DNA Repair DNA Damage Response Cell Projection Organization Cell Division Cilium Assembly
Pathways		Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Dual incision in TC-NER	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Serum thyroid-stimulating hormone levels ( 24852370) Thyroid cancer (Papillary, radiation-related) ( 20350937)	Apolipoprotein A1 levels ( 32203549) Diastolic blood pressure ( 30578418) Diffusing capacity of carbon monoxide ( 30694715) Hematocrit ( 32888494) Hemoglobin levels ( 32327693) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Metabolite levels ( 23823483) Pulse pressure ( 27841878 28135244 30578418)
Interacting Genes		51 interacting genes: ARID3A ATM ATR AURKA BMPR1A BUB1 CEP164 DDB1 DDB2 DLC1 DVL3 ERCC1 ERCC6 FBXW7 GPN1 GTF2E2 GTF2H1 HERC2 MEOX2 MLH1 MLH3 MSH2 MSH3 MUTYH NDEL1 NRAS PCNA PDGFRL PICK1 PMS2 POLR1C PRDM16 PRKDC PSMB1 RASSF1 RB1 RHOU RPA1 RPA2 RPA4 SKIL SMAD2 SNPH SRC STK11 TBC1D7 TRIM27 VPS26C XAB2 XPC ZNF655	6 interacting genes: ATR ATRIP CLP1 MAPK14 UBC XPA
Entrez ID		7507	22897
HPRD ID		02045	10854
Ensembl ID		ENSG00000136936	ENSG00000110274
Uniprot IDs		P23025	Q9UPV0
PDB IDs		1D4U 1XPA 2JNW 6J44 6LAE 6RO4 7AD8 8EBT 8EBU 8EBX 8EBY	7NWJ 7O06 7O0S 7O3B
Enriched GO Terms of Interacting Partners?		DNA Damage Response DNA Repair Mismatch Repair DNA Metabolic Process Cellular Response To Stress Nucleotide-excision Repair Chromosome Organization Nucleoplasm Nucleic Acid Metabolic Process Regulation Of Cell Cycle Phase Transition ATP-dependent DNA Damage Sensor Activity Damaged DNA Binding Response To UV Single-stranded DNA Binding Response To Stress Negative Regulation Of Cell Cycle Phase Transition Somatic Cell DNA Recombination Mismatched DNA Binding DNA Recombination Chromosome, Telomeric Region Nucleus DNA Binding Cellular Response To UV Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process DNA Damage Checkpoint Signaling Somatic Recombination Of Immunoglobulin Gene Segments Double-strand Break Repair Cellular Response To Light Stimulus Cellular Response To Radiation Regulation Of Cell Cycle Process MutSalpha Complex Binding MutLalpha Complex Binding Somatic Diversification Of Immunoglobulins Response To Radiation Negative Regulation Of Cell Cycle Negative Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Pyrimidine Dimer Repair Negative Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Regulation Of DNA Metabolic Process Telomere Maintenance UV-damage Excision Repair Histone H2AXS139 Kinase Activity Dinucleotide Insertion Or Deletion Binding Regulation Of Mitotic Cell Cycle Protein Localization To Chromosome Response To Light Stimulus Regulation Of Mitotic Cell Cycle Phase Transition	ATR-ATRIP Complex Cellular Response To UV Cellular Response To Light Stimulus DNA Damage Checkpoint Signaling Response To UV Signal Transduction In Response To DNA Damage Cellular Response To Radiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Phase Transition DNA Damage Response Negative Regulation Of Cell Cycle Process Response To Light Stimulus Negative Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Nucleic Acid Metabolic Process Nucleotide-excision Repair, DNA Damage Recognition Response To Radiation Regulation Of Cell Cycle Phase Transition Establishment Of Protein-containing Complex Localization To Telomere Nucleoplasm Establishment Of RNA Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Nucleotide-excision Repair Involved In Interstrand Cross-link Repair ATP-dependent Polyribonucleotide 5'-hydroxyl-kinase Activity Polynucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polynucleotide 5'-hydroxyl-kinase Activity DNA Repair Histone H2AXS139 Kinase Activity Regulation Of Synaptic Membrane Adhesion Nucleotide-excision Repair Factor 1 Complex Global Gene Silencing By MRNA Cleavage Kinase Activity Response To Ionizing Radiation Regulation Of Double-strand Break Repair TRNA-intron Endonuclease Complex ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity Cellular Response To Stress DNA Metabolic Process Regulation Of Cell Cycle Process NFAT Protein Binding MRNA Cleavage Factor Complex Response To Mechanical Stimulus MutSalpha Complex Binding Macromolecule Metabolic Process MutLalpha Complex Binding Mitogen-activated Protein Kinase P38 Binding Stress-induced Premature Senescence Cerebellar Cortex Development Intracellular Signal Transduction NLRP1 Inflammasome Complex Assembly
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