GEMIN4 and CCT3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GEMIN4	CCT3
Description		gem nuclear organelle associated protein 4	chaperonin containing TCP1 subunit 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Body Small Nuclear Ribonucleoprotein Complex SMN Complex SMN-Sm Protein Complex Extracellular Exosome Gemini Of Cajal Bodies	Zona Pellucida Receptor Complex Cytoplasm Cytosol Chaperonin-containing T-complex Cytoskeleton Microtubule Cell Body Extracellular Exosome
	Molecular Function	Protein Binding Ribonucleoprotein Complex Binding	Nucleotide Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Spliceosomal SnRNP Assembly RRNA Processing MRNA Processing RNA Splicing	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		snRNP Assembly SARS-CoV-2 modulates host translation machinery	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs			Phosphoaminophosphonic Acid-Adenylate Ester Artenimol
Diseases
GWAS		Prostate cancer ( 23535732)	Basophil count ( 32888494) Glycated hemoglobin levels ( 24647736) Household income (MTAG) ( 31844048) Mean corpuscular hemoglobin concentration ( 20139978) Mean corpuscular volume ( 29403010) Red blood cell count ( 29403010) Red cell distribution width ( 32888494) Subcutaneous adipose tissue ( 22589738) Walking pace ( 33128006)
Interacting Genes		57 interacting genes: AGO2 ALPP CALCOCO2 CCDC185 CCT3 CDC20B CERCAM CFP DDX20 DHX9 DMPK FBXL12 FLAD1 GEMIN5 GLYR1 HR KANK2 KARS1 KRTAP13-2 KRTAP13-4 KRTAP15-1 KRTAP2-3 KRTAP2-4 KRTAP9-2 LGALS1 LGALS3 LY86 MORC4 NPPB NUFIP1 PIAS3 PSMB1 PTCD1 PTEN RAD51D RN7SL1 RNASE2 RNF10 RNU1-1 RNU2-1 S1PR4 SNRPB SNRPD1 SNRPD2 SPG21 SPRY1 SQSTM1 SRRT STXBP2 STXBP3 TAP1 TOP1 UFC1 USP15 USP2 ZNF326 ZNF35	26 interacting genes: BUD31 CEBPA DEPDC5 EIF2B2 ERBB2 FANCA GEMIN4 HNRNPA0 HSPA8 LINC01554 LNX2 MAPK6 MIPOL1 OGT PAFAH1B2 POLR1C PTEN RAF1 SH3BP4 SHANK3 SUMO2 UBE2Z VAV2 VHL XRCC6 ZNRD2
Entrez ID		50628	7203
HPRD ID		07370	08969
Ensembl ID		ENSG00000179409	ENSG00000163468
Uniprot IDs		I3L2C7 P57678 Q8WUM5 Q9HC39	B3KX11 P49368 Q59H77
PDB IDs			6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP 7NVL 7NVM 7NVN 7NVO 7TRG 7TTN 7TTT 7TUB 7WU7 7WZ3 7X0A 7X0S 7X0V 7X3J 7X3U 7X6Q 7X7Y 8HKI 8I1U 8I6J 8I9U 8IB8 8SFE 8SFF 8SG8 8SG9 8SGC 8SGL 8SGQ 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT
Enriched GO Terms of Interacting Partners?		SMN-Sm Protein Complex Protein-RNA Complex Assembly Spliceosomal SnRNP Assembly U2 SnRNP 7-methylguanosine Cap Hypermethylation RNA Processing U4 SnRNP Methylosome Intermediate Filament Small Nuclear Ribonucleoprotein Complex RNA Splicing U1 SnRNP Tertiary Granule U5 SnRNP Presynaptic Dense Core Vesicle Exocytosis U2-type Prespliceosome Assembly U12-type Spliceosomal Complex MRNA Processing Perichromatin Fibrils U2-type Spliceosomal Complex RNA Polymerase II Complex Binding U2-type Catalytic Step 2 Spliceosome RNA Metabolic Process Positive Regulation Of Dendritic Cell Differentiation PICln-Sm Protein Complex Neuronal Dense Core Vesicle Exocytosis U1 SnRNP Binding Neutrophil Degranulation Transcription Elongation-coupled Chromatin Remodeling Keratin Filament RISC-loading Complex Dense Core Granule Exocytosis U4/U6 X U5 Tri-snRNP Complex RNA Binding Anaphase-promoting Complex Binding Calcium Ion-regulated Exocytosis Of Neurotransmitter RISC Complex Assembly MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly SiRNA Binding SMN Complex U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions Cytosol Locomotor Rhythm Ubiquitin Ligase Activator Activity Gemini Of Cajal Bodies Protein Binding Ribonucleoside Triphosphate Phosphatase Activity MRNA Metabolic Process	Protein Localization To Lysosome Positive Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Protein Localization To Vacuole Postsynaptic Density Assembly ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Regulation Of TOR Signaling Glial Cell Development Postsynaptic Specialization Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Positive Regulation Of Catabolic Process Positive Regulation Of Proteolysis Transcription By RNA Polymerase I Intracellular Signaling Cassette Regulation Of Protein Metabolic Process Regulation Of Cell Size Schwann Cell Development Myelination Axon Ensheathment Cytosol Postsynaptic Density Organization Dendritic Spine Morphogenesis Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription ERBB2 Signaling Pathway Regulation Of Translational Initiation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Postsynaptic Specialization Organization Identical Protein Binding Secretory Granule Lumen Intracellular Signal Transduction Ficolin-1-rich Granule Lumen Nucleus Cytoplasm Positive Regulation Of RNA Metabolic Process Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Biosynthetic Process Response To Stress Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
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