GEMIN4 and NUFIP1

Number of citations of the paper that reports this interaction (PubMedID 26275778)
67

Data Source:
BioGRID (two hybrid)

		GEMIN4	NUFIP1
Description		gem nuclear organelle associated protein 4	nuclear FMR1 interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Body Small Nuclear Ribonucleoprotein Complex SMN Complex SMN-Sm Protein Complex Extracellular Exosome Gemini Of Cajal Bodies	Fibrillar Center Nucleus Nucleoplasm Perichromatin Fibrils Nucleolus Transcription Elongation Factor Complex Nuclear Matrix Protein-containing Complex Synapse Presynaptic Active Zone Pre-snoRNP Complex
	Molecular Function	Protein Binding Ribonucleoprotein Complex Binding	DNA Binding RNA Binding Protein Binding Zinc Ion Binding SnoRNA Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Metal Ion Binding ATPase Binding
	Biological Process	Spliceosomal SnRNP Assembly RRNA Processing MRNA Processing RNA Splicing	Box C/D SnoRNP Assembly RNA Processing Positive Regulation Of Transcription By RNA Polymerase II
Pathways		snRNP Assembly SARS-CoV-2 modulates host translation machinery
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Body mass index ( 25760438) HDL cholesterol levels ( 32203549) Oleic acid (18:1n-9) levels ( 23362303) Refractive error ( 32231278) Rosacea symptom severity ( 29771307)
Interacting Genes		57 interacting genes: AGO2 ALPP CALCOCO2 CCDC185 CCT3 CDC20B CERCAM CFP DDX20 DHX9 DMPK FBXL12 FLAD1 GEMIN5 GLYR1 HR KANK2 KARS1 KRTAP13-2 KRTAP13-4 KRTAP15-1 KRTAP2-3 KRTAP2-4 KRTAP9-2 LGALS1 LGALS3 LY86 MORC4 NPPB NUFIP1 PIAS3 PSMB1 PTCD1 PTEN RAD51D RN7SL1 RNASE2 RNF10 RNU1-1 RNU2-1 S1PR4 SNRPB SNRPD1 SNRPD2 SPG21 SPRY1 SQSTM1 SRRT STXBP2 STXBP3 TAP1 TOP1 UFC1 USP15 USP2 ZNF326 ZNF35	12 interacting genes: BRCA1 CCNT1 DDX20 FMR1 GEMIN2 GEMIN4 GEMIN6 KLF6 OGT SNU13 TAF9 TTC3
Entrez ID		50628	26747
HPRD ID		07370	05073
Ensembl ID		ENSG00000179409	ENSG00000083635
Uniprot IDs		I3L2C7 P57678 Q8WUM5 Q9HC39	Q9UHK0
PDB IDs			5L85
Enriched GO Terms of Interacting Partners?		SMN-Sm Protein Complex Protein-RNA Complex Assembly Spliceosomal SnRNP Assembly U2 SnRNP 7-methylguanosine Cap Hypermethylation RNA Processing U4 SnRNP Methylosome Intermediate Filament Small Nuclear Ribonucleoprotein Complex RNA Splicing U1 SnRNP Tertiary Granule U5 SnRNP Presynaptic Dense Core Vesicle Exocytosis U2-type Prespliceosome Assembly U12-type Spliceosomal Complex MRNA Processing Perichromatin Fibrils U2-type Spliceosomal Complex RNA Polymerase II Complex Binding U2-type Catalytic Step 2 Spliceosome RNA Metabolic Process Positive Regulation Of Dendritic Cell Differentiation PICln-Sm Protein Complex Neuronal Dense Core Vesicle Exocytosis U1 SnRNP Binding Neutrophil Degranulation Transcription Elongation-coupled Chromatin Remodeling Keratin Filament RISC-loading Complex Dense Core Granule Exocytosis U4/U6 X U5 Tri-snRNP Complex RNA Binding Anaphase-promoting Complex Binding Calcium Ion-regulated Exocytosis Of Neurotransmitter RISC Complex Assembly MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly SiRNA Binding SMN Complex U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions Cytosol Locomotor Rhythm Ubiquitin Ligase Activator Activity Gemini Of Cajal Bodies Protein Binding Ribonucleoside Triphosphate Phosphatase Activity MRNA Metabolic Process	SMN Complex Gemini Of Cajal Bodies SMN-Sm Protein Complex Protein-RNA Complex Assembly Spliceosomal SnRNP Assembly Nucleoplasm MRNA Metabolic Process RNA Splicing MRNA Processing Nucleic Acid Metabolic Process RNA Metabolic Process Nucleolus Nuclear Body Nucleobase-containing Compound Metabolic Process Protein-containing Complex Assembly Nucleus Macromolecule Metabolic Process RNA Processing Protein-containing Complex Organization Box C/D SnoRNP Assembly Cellular Component Assembly RNA Polymerase Binding DNA-binding Transcription Factor Binding Regulation Of Lipid Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process RNA Splicing, Via Transesterification Reactions Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Spliceosomal Complex Assembly Molecular Condensate Scaffold Activity Transcription Cis-regulatory Region Binding Positive Regulation Of Intracellular Transport Of Viral Material Box C/D Sno(s)RNA Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Cajal Body Positive Regulation Of Transcription By RNA Polymerase II P53 Binding Regulation Of Lipid Metabolic Process Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Host-mediated Perturbation Of Viral Process P-TEFb Complex Dendritic Filopodium Histone H3 Reader Activity U4atac SnRNP Dense Fibrillar Component
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